Publications by authors named "Linling Yin"
Article Synopsis
- Cuproptosis is a new type of programmed cell death that holds promise for cancer treatment by exploiting mitochondrial pathways and enhancing oxidative stress within tumor cells.* -
- The study introduces a nanoreactor called CaCuZC, which combines calcium peroxide and IR780 carbon dots to induce cellular damage through increased copper and calcium levels, leading to both cuproptosis and ferroptosis.* -
- By activating cytotoxic T cells and facilitating an anti-tumor immune response, this innovative approach aims to convert "cold" tumors into "hot" tumors to enhance the effectiveness of immunotherapy.*
Article Synopsis
- Periodontitis is a chronic inflammatory disease that leads to plaque buildup and damage to the bone that supports teeth, prompting the need for effective treatments to promote bone healing.
- Researchers developed a new biomaterial called C-KR8, which helps switch macrophages to a regenerative state and supports bone growth in conditions like periodontitis.
- C-KR8 is delivered using nanoparticles (C-KR8@ZIF-8) that release it and zinc; this approach enhances the healing process by interacting with key proteins and activating important cell signaling pathways.
This study aimed to develop a sonodynamic-chemodynamic nanoparticle functioning on glutathione depletion in tumor immunotherapy. The liposome-encapsulated 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH) and copper-cysteine nanoparticles, AIPH/Cu-Cys@Lipo, were synthesized with a one-pot method. 4T1 cells were injected into female BALB/c mice for modeling.
View Article and Find Full Text PDFBACKGROUND Osteogenic differentiation of periodontal ligament stem cells (PDLSCs) is associated with periodontitis. It has been reported that long noncoding RNA X-inactive specific transcript (lncRNA XIST) is upregulated and microRNA-214-3p (miR-214-3p) is downregulated in PDLSCs after osteogenic induction. However, whether XIST is involved in osteogenic differentiation of PDLSCs via miR-214-3p has not been reported.
View Article and Find Full Text PDFWe investigated the therapeutic effects of microRNA-139-5p in relation to osteoporosis of bone marrow-derived mesenchymal stem cell (BMSCs) and its underlying mechanisms. In this study we used a dexamethasone-induced in vivo model of osteoporosis and BMSCs were used for the in vitro model. Real-time quantitative polymerase chain reaction (RT-PCR) and gene chip were used to analyze the expression of microRNA-139-5p.
View Article and Find Full Text PDFA novel double-layered antibacterial coating was fabricated on pure titanium (Ti) a simple three-step electrodeposition process. Scanning electronic microscopy (SEM) images show that the coating was constructed with the inner layer of TiO nanotubes doped with silver nanoparticles (TNTs/Ag) and the outer layer of chitosan-gelatin mixture with zinc oxide and silver nanoparticles (CS-Gel-Ag-ZnO). In comparison, we also investigated the composition, structure and antibacterial properties of pure Ti coated with TNTs, TNTs/Ag or TNTs/Ag + CS-Gel-Ag-ZnO, respectively.
View Article and Find Full Text PDFBackground/aims: Accumulating evidence demonstrates the superior osteoinductivity of tantalum (Ta) to that of titanium (Ti); however, the mechanisms underlying these differences are unclear. Thus, the objective of the present study was to examine the effects of Ta and Ti surfaces on osteogenesis using rat bone mesenchymal stromal cells (rBMSCs) as a model.
Methods: Ta and Ti substrates were polished to a mirror finish to minimize the influences of structural factors, and the intrinsic surface effects of the two materials on the integrin α5β1/mitogen-activated protein kinases 3 and 1 (ERK1/2) cascade-mediated osteogenesis of rBMSCs were evaluated.
The purpose of this study was to evaluate the roles of different housing environments in neurological function, cerebral metabolism, cerebral infarction and neuron apoptosis after focal cerebral ischemia. Twenty-eight Sprague-Dawley rats were divided into control group (CG) and cerebral ischemia group, and the latter was further divided into subgroups of different housing conditions: standard environment (SE) subgroup, individual living environment (IE) subgroup, and enriched environment (EE) subgroup. Focal cerebral ischemia was induced by the middle cerebral artery occlusion (MCAO).
View Article and Find Full Text PDF[Research on periodontal changes on the compression side during rapid tooth movement into newly distracted bone].
Shanghai Kou Qiang Yi Xue
December 2011
Purpose: To investigate periodontal remodeling mechanism on the compression side during early tooth movement into newly distracted bone.
Methods: Ten male Beagle dogs were selected. Distraction osteogenesis was performed on randomized side as experimental group, while the fourth premolars were extracted on the other side as control group.