Occupational stress trajectories and metabolic dysfunction-associated steatotic liver disease among female nurses: a prospective Cohort Study.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prominent cause of chronic liver disease, and occupational stress may serve as a potential risk factor. This study aims to assess the association between occupational stress trajectories and incident MASLD among Chinese female nurses.

Methods: We conducted a prospective longitudinal study using data from the Nurse' Health Cohort Study, involving 1,113 female nurses, free of MASLD at baseline (2018).

Combination of Hollow Capsule Structure and Zn Uniform Load for the Conversion of Methanol to Aromatics over Zn/ZSM-5 Zeolites.

As an important nonoil route for acquiring aromatics, the highly efficient conversion of methanol to aromatics over Zn/ZSM-5 zeolites remains an ongoing challenge. In this work, we developed a uniform loading approach of zinc and further combined it with a hollow capsule structure to design the high-performance Zn/ZSM-5 catalyst. The electrostatic assembly among EDTA, -butylamine and negative silica-alumina gel gave rise to an "Inorganic-Organic Hybrid Sphere" in form of Na·{[(SiO)Al]/(SiO)(-butylamine)(EDTA)(-butylamine)(SiO), which further transformed into mesoporous aluminosilicates sphere (MASS) through calcination.

BAMRE: Joint extraction model of Chinese medical entities and relations based on Biaffine transformation with relation attention.

Electronic Health Records (EHRs) contain various valuable medical entities and their relationships. Although the extraction of biomedical relationships has achieved good results in the mining of electronic health records and the construction of biomedical knowledge bases, there are still some problems. There may be implied complex associations between entities and relationships in overlapping triplets, and ignoring these interactions may lead to a decrease in the accuracy of entity extraction.

GEFormerDTA: drug target affinity prediction based on transformer graph for early fusion.

Predicting the interaction affinity between drugs and target proteins is crucial for rapid and accurate drug discovery and repositioning. Therefore, more accurate prediction of DTA has become a key area of research in the field of drug discovery and drug repositioning. However, traditional experimental methods have disadvantages such as long operation cycles, high manpower requirements, and high economic costs, making it difficult to predict specific interactions between drugs and target proteins quickly and accurately.

Attention-Based Sentiment Region Importance and Relationship Analysis for Image Sentiment Recognition.

Image sentiment recognition has attracted considerable attention from academia and industry due to the increasing tendency of expressing opinions via images and videos online. Previous studies focus on multilevel representation from global and local views to improve recognition performance. However, it is insufficient to research the importance and relationship of visual regions for image sentiment recognition.

Association Between Passive Smoking and Menstrual Discomfort: A Cross-Sectional Study of 2,571 Non-smoking Chinese Nurses.

Introduction: Menstrual discomfort affects women's quality of life, which is an important public health issue. Evidence confirming the link between passive smoking and menstrual discomfort is limited. Therefore, the aim of this study is to investigate the aforementioned topic on the basis of a cross-sectional study of 2,571 non-smoking Chinese nurses.

Association Between Passive Smoking and Health Among Chinese Nurses: A Cross-Sectional Study.

This study aimed to investigate the association between passive smoking and physical and psychological health in Chinese nurses. Participants of this cross-sectional study comprised 2,484 non-smoking nurses. Passive smoking and demographic information were assessed using a self-administered questionnaire.

Hsa_circ_0004831 serves as a blood-based prognostic biomarker for colorectal cancer and its potentially circRNA-miRNA-mRNA regulatory network construction.

Background: Colorectal cancer (CRC) is a common malignant tumor with unsatisfactory overall prognosis. CircRNAs could be promising prognostic biomarkers in cancers, and play important role in the process of tumorigenesis and progression. Here, we explored the role of hsa_circ_0004831 in blood extracellular vesicles and its prognostic value in CRC.

Regioselective Chlorolactonization of Styrene-Type Carboxylic Esters and Amides via PhICl-Mediated Oxidative C-O/C-Cl Bond Formations.

A facile method employing styrene-type carboxylic esters or amides in the presence of PhICl in CHCN was developed to achieve the synthesis of 6- products 3,4-dihydroisocoumarins or 3,4-dihydroisocoumarin-1-imines in good to high yields. This metal-free regioselective intramolecular chlorolactonization process was proposed to involve a PhICl-mediated oxidative C-O bond formation followed by C-Cl bond formation.

Ozonation catalyzed by iron- and/or manganese-supported granular activated carbons for the treatment of phenol.

Iron- and/or manganese-supported catalysts on granular activated carbons (Fe and/or Mn/GACs) were prepared, and their catalytic activities were evaluated by using them to treat phenol and secondary petrochemical effluent via ozonation. The presence of Fe and/or Mn/GACs significantly improved the degradation and degree of phenol mineralization. Changes in dissolved ozone concentrations and the effects of carbonate and tert-butyl alcohol (TBA) indicated that the prepared catalyst enhanced the decomposition of ozone into hydroxyl radicals (·OH), which was determined to be a key factor in catalyzing the ozonation of phenol.

In Situ Formation of RSCl/ArSeCl and Their Application to the Synthesis of 4-Chalcogenylisocumarins/Pyrones from o-(1-Alkynyl)benzoates and ( Z)-2-Alken-4-ynoates.

The reaction of diorganyl disulfides or diselenides with PhICl in acetonitrile was found for the first time to lead to the in situ formation of organosulfenyl chloride or selenenyl chloride, which enables the regioselective intramolecular chalcogenylacyloxylation of alkynes resulting in the formation of 4-chalcogenylisocumarins/pyrones in good to excellent yields under metal-free conditions.

Synthesis of 4-Chloroisocoumarins via Intramolecular Halolactonization of o-Alkynylbenzoates: PhICl-Mediated C-O/C-Cl Bond Formation.

A series of 4-chloroisocoumarins were conveniently synthesized from o-alkynylbenzoates via PhICl-mediated intramolecular cyclization under metal-free conditions. PhICl plays the role of both the oxidant and the chlorine source to enable oxidative C-O bond formation and introduction of the chlorine atom. The utility and practicability of this protocol have been exemplified by virtue of mild reaction conditions, high-yielding products, simplified purification, and gram-scale synthesis.

Practical Glucosylations and Mannosylations Using Anomeric Benzoyloxy as a Leaving Group Activated by Sulfonium Ion.

One obstacle for practical glycosylations is the high cost of promoters and low-temperature equipment. This problem has been at least partially solved by using MeSCHCl/KI as a low-cost promoter system. MeSCHCl has an estimated cost of <$1/mol compared with $1741/mol for AgOTf and $633/mol for TMSOTf.

Gene Regulatory Networks Reconstruction Using the Flooding-Pruning Hill-Climbing Algorithm.

The explosion of genomic data provides new opportunities to improve the task of gene regulatory network reconstruction. Because of its inherent probability character, the Bayesian network is one of the most promising methods. However, excessive computation time and the requirements of a large number of biological samples reduce its effectiveness and application to gene regulatory network reconstruction.

Constructing an integrated gene similarity network for the identification of disease genes.

Background: Discovering novel genes that are involved human diseases is a challenging task in biomedical research. In recent years, several computational approaches have been proposed to prioritize candidate disease genes. Most of these methods are mainly based on protein-protein interaction (PPI) networks.

An improved Bayesian network method for reconstructing gene regulatory network based on candidate auto selection.

Background: The reconstruction of gene regulatory network (GRN) from gene expression data can discover regulatory relationships among genes and gain deep insights into the complicated regulation mechanism of life. However, it is still a great challenge in systems biology and bioinformatics. During the past years, numerous computational approaches have been developed for this goal, and Bayesian network (BN) methods draw most of attention among these methods because of its inherent probability characteristics.

Genome-wide mining of potential virulence-associated genes in Riemerella anatipestifer using random transposon mutagenesis.

Riemerella anatipestifer infection is a severe disease confronting the duck industry worldwide. However, little is known about the molecular basis of R. anatipestifer pathogenesis.

Epidemiology and Clinical Characteristics of Pediatric Drug-Resistant Tuberculosis in Chongqing, China.

To gain insight into the epidemiology of childhood drug resistant tuberculosis (DR-TB) in China that has the second largest burden of TB and the largest number of multidrug resistant (MDR) TB cases in the world, we performed the cross-sectional study to investigate drug resistance of four first-line anti-TB drugs (isoniazid, rifampicin, streptomycin and ethambutol) using Mycobacterium tuberculosis isolates from 196 culture-confirmed pediatric TB cases diagnosed in the Children's Hospital of Chongqing Medical University, China during 2008-2013. Univariate and multivariate logistic regression analyses were performed to assess the associations between patient demographic and clinical characteristics and DR-and MDR-TB, respectively. Twenty-eight percent (56/196) of the study patients exhibited resistance to at least one of the four first-line anti-TB drugs tested.

Stereoselective Chlorination and Bromination of Enamides and Enamines via an Electrostatic Attraction Effect Using (1,1-Diacetoxyiodo)benzene and a Halide Source.

The direct chlorination and bromination of (E)-enamines and (Z)-enamides to the corresponding (Z)-configurated α-chloroenamines, α-bromoenamines, and α-chloroenamides have been realized using NiCl2·6H2O or tetrabutyl ammonium bromide as a halide source and (1,1-diacetoxyiodo)benzene as an oxidant. The high stereoselective reactions which produce products with only (Z)-configurations can be attributed to the structure of the intermediates, the conformations of which are controlled by the electrostatic attractions between the positively charged nitrogen atoms and the oxygen atoms of the carbonyl group. This type of electrostatic effect has never been reported in olefin halogenations.

Roles of the TonB1 and TonB2 proteins in haemin iron acquisition and virulence in Riemerella anatipestifer.

Two TonB systems in Riemerella anatipestifer were found and characterized as ExbB1-ExbD1-TonB1 and ExbB2-ExbD2-ExbD2'-TonB2, but the significance of two sets of TonB complexes in R. anatipestifer is not clear. In this study, by deleting the tonB1 or tonB2 gene of R.

Host and Microbial Predictors of Childhood Extrathoracic Tuberculosis and Tuberculosis Meningitis.

Background: Childhood tuberculosis (TB) is a major infectious disease causing morbidity and mortality in children and yet has been largely ignored until recently. This study is the first study to characterize childhood TB in China incorporating both Mycobacterium tuberculosis genetic characteristics and patient data.

Methods: We analyzed a total of 331 culture-confirmed childhood TB cases and 158 M.

ErmF and ereD are responsible for erythromycin resistance in Riemerella anatipestifer.

To investigate the genetic basis of erythromycin resistance in Riemerella anatipestifer, the MIC to erythromycin of 79 R. anatipestifer isolates from China and one typed strain, ATCC11845, were evaluated. The results showed that 43 of 80 (53.

Activated carbon enhanced ozonation of oxalate attributed to HO oxidation in bulk solution and surface oxidation: effect of activated carbon dosage and pH.

Ozonation of oxalate in aqueous phase was performed with a commercial activated carbon (AC) in this work. The effect of AC dosage and solution pH on the contribution of hydroxyl radicals (HO) in bulk solution and oxidation on the AC surface to the removal of oxalate was studied. We found that the removal of oxalate was reduced by tert-butyl alcohol (tBA) with low dosages of AC, while it was hardly affected by tBA when the AC dosage was greater than 0.

The siderophore-interacting protein is involved in iron acquisition and virulence of Riemerella anatipestifer strain CH3.

Riemerella anatipestifer causes epizootic infectious disease in poultry and serious economic losses especially to the duck industry. However, little is known regarding the molecular basis of its pathogenesis. The ability to acquire iron under low-iron conditions is related to the virulence of a variety of bacterial pathogens.