Publications by authors named "Linlin Xiao"

Purpose: This study aims to optimize neoadjuvant radiotherapy target area for locally advanced rectal cancer (LARC) patients undergoing total neoadjuvant therapy (TNT) by examining local recurrence patterns.

Methods And Materials: We retrospectively analyzed the clinical data of rectal cancer patients who undergone local recurrence after surgery. Recurrence sites were categorized and compared with initial diagnosis imaging, focusing on visible and suspicious lesions.

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Hydrogen gas (H) plays a crucial role in mitigating salt stress in plants, but the underlying mechanisms is largely unknown. Herein, we employed the pharmacological, molecular, and genetic approaches to investigate the positive roles of hydrogen peroxide (HO) in endogenous H-induced salt tolerance of Arabidopsis thaliana. H-induecd salt tolerance of CrHYD1 (hydrogenase 1 gene from Chlamydomonas reinhardtii) transgenic Arabidopsis was blocked by HO scavenger or NADPH oxidase inhibitor.

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Rationale: Small-cell undifferentiated carcinoma (SmCC), as an aggressive malignancy, are most commonly arising in lung. Extrapulmonary SmCC is rare. It was reported that SmCC accounts for only 0.

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Objective: This study investigated the predictive value of albumin-related inflammatory markers for short-term outcomes in in-hospital cardiac arrest (IHCA) patients.

Methods: A linear mixed model investigated the dynamic changes of markers within 72 hours after return of spontaneous circulation (ROSC). Time-Dependent COX regression explored the predictive value.

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Metformin has shown outstanding anti-inflammatory and osteogenic abilities. Mesenchymal stem cell-derived extracellular vesicles (EVs) reveal promising therapeutic potency by carrying various biomolecules. This study explored the effects of metformin on the therapeutic potential of EVs derived from human periodontal ligament stem cells (PDLSCs) for periodontitis.

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Autophagy in alveolar macrophages (AMs) is an important mechanism for maintaining immune homeostasis and normal lung tissue function, and insufficient autophagy in AMs may mediate the development of sepsis-induced acute lung injury (SALI). Insufficient autophagy in AMs and the activation of the NLRP3 inflammasome were observed in a mouse model with SALI induced by cecal ligation and puncture (CLP), resulting in the release of a substantial quantity of proinflammatory factors and the formation of SALI. However, after andrographolide (AG) intervention, autophagy in AMs was significantly promoted, the activation of the NLRP3 inflammasome was inhibited, the release of proinflammatory factors and pyroptosis were suppressed, and SALI was then ameliorated.

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Article Synopsis
  • - The study aimed to analyze how the knockout of the MAL gene affects lung tissue structure and the expression of E-cadherin and alpha-smooth muscle actin in a mouse model of asthma.
  • - Researchers created four groups of mice, including wild-type and gene knockout models, to confirm asthma symptoms and reveal differences in lung tissue using various staining techniques and molecular analyses.
  • - Results indicated that MAL gene knockout led to significant changes in lung structure and protein expression related to asthma, suggesting that the MAL gene plays a crucial role in maintaining airway stability and inhibiting epithelial-mesenchymal transition (EMT).
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In previous edge detection schemes based on the spin-orbit interaction of light, the direction and intensity of the edge-enhanced images are influenced by the incident polarization state. In this study, we develop an edge detection strategy that is insensitive to changes in both the incident polarization and the incident angle. The output intensity and transfer function remain entirely impervious to changes in incident polarization, being explicitly formulated as functions of the incident angle, specifically in terms of ⁡ and ⁡ , respectively.

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Background: Several studies have explored the effectiveness of PD-1/PD-L1 inhibitors combined with neoadjuvant chemoradiotherapy (nCRT) in the treatment of locally advanced rectal cancer(LARC), particularly in microsatellite stable(MSS) or mismatch repair proficient(pMMR) LARC patients. We undertook a single-arm systematic review to comprehensively evaluate the advantages and potential risks associated with the use of PD-1/PD-L1 inhibitors in conjunction with nCRT for patients diagnosed with locally advanced rectal cancer.

Methods: The PubMed, Embase, Cochrane Library, ClinicalTrials.

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Article Synopsis
  • Mucoepidermoid Carcinoma of the Esophagus (MECE) is a rare type of tumor, primarily affecting males, and has a low preoperative diagnosis rate of just 6.3%.
  • A study on 48 patients showed 10-year survival rates of 31%, with significant prognostic factors being T and N staging.
  • No significant survival differences were found when comparing MEC patients to those with more common esophageal cancers (ESCC and EAC).
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Carotid artery puncture is a common complication of internal jugular vein (IJV) catheterization. However, there are few reports about an aneurysm from the carotid artery that can develop into an occult mediastinal hematoma, leading to airway compression. In this case study, we present the case of a 71-year-old male who experienced an aneurysm and delayed mediastinal hematoma, ultimately resulting in airway compression after right jugular line insertion.

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Article Synopsis
  • * SD rats were immunized with the vaccine, and results showed that those receiving a higher dosage (8 mL/kg) developed significantly more antibodies and had fewer caries compared to other groups.
  • * RNA sequencing analysis revealed 40 genes with altered expression in vaccinated rats, with key pathways related to immune response being activated, including the PI3K-AKT pathway, suggesting the vaccine might work by enhancing these immune processes.
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Background: This study aimed to compare the efficacy of focused ultrasound (FUS) and the loop electrosurgical excision procedure (LEEP) for the treatment of cervical high-grade squamous intraepithelial lesions (HSILs) among women of reproductive age.

Methods: Case records of patients aged < 40 years who were treated for cervical HSILs using either FUS or LEEP from September 1, 2020 to May 31, 2022 were retrospectively reviewed. Patients were followed up for cure, recurrence, human papillomavirus (HPV) clearance, and complications within 1 year of treatment.

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multi-system and multi-organ dysfunction, and is easily misdiagnosed early in the disease course. We aimed to accurately predict early SLE nomogram to provide a reference basis for the early clinical diagnosis of SLE. : We retrospectively analyzed 167 patients who were first diagnosed with SLE at Fengxian District Central Hospital, Shanghai, between March 2017 and October 2022.

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Objective: To establish a nasopharyngeal carcinoma-specific big data platform based on electronic health records (EHRs) to provide data support for real-world study of nasopharyngeal carcinoma.

Methods: A multidisciplinary expert team was established for this project. Based on industry standards and practical feasibility, the team designed the nasopharyngeal carcinoma data element standards including 14 modules and 640 fields.

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  • The review aimed to examine the impact of chewing gum on pain from orthodontic treatments and the frequency of bracket breakage associated with fixed braces.
  • The analysis involved 15 studies with over 2,000 participants, finding that chewing gum significantly alleviated orthodontic pain compared to no treatment and performed similarly to analgesics.
  • Chewing gum did not increase the likelihood of bracket breakage and is suggested as a cost-effective, non-invasive alternative for pain relief in orthodontics.
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  • - AFF4 is a scaffold protein in the superelongation complex (SEC), playing a crucial role as a transcription elongation factor that influences HIV activation, replication, and stem cell differentiation.
  • - This protein is linked to the progression of various cancers, including head and neck squamous cell carcinoma, leukemia, and breast cancer, by regulating key transcription factors and interacting with other proteins involved in cellular processes.
  • - The mini-view discusses the potential of targeting AFF4 for therapeutic purposes in treating AIDS and various cancers, as well as its role in maintaining stem cell characteristics.
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  • Granulosa cells are essential for producing estrogens that support follicular growth in buffalo.
  • The study investigated how testosterone affects estrogen production in these cells.
  • Findings revealed that adding testosterone at a specific concentration boosted estrogen synthesis in granulosa cells, contributing to understanding of ovarian hormone regulation.
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Background: Rectal squamous cell carcinoma (RSCC) is a rare malignancy of the rectal tumor. Due to its extremely low incidence, there is still a lack of high-level treatment evidence and clinical consensus on this disease.

Case Report: In this article, we report a treatment process of RSCC with high PD-L1 expression.

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Purpose: To investigate the clinical factors affecting pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC).

Methods: Clinical data of 124 LARC patients treated with nCRT and surgery in the fourth Hospital of Hebei Medical University from 2014 to 2019 were retrospectively analyzed. In this study, univariate analysis and logistic dichotomous multivariate regression analysis were used to study the clinical factors affecting pCR, and the receiver operator characteristic curve (ROC) analysis was used to further verify the accuracy of partial indexes in predicting pCR.

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Introduction: To evaluate the predictive value of F-fluorodeoxyglucose positron emission tomography-computed tomography (F-FDG PET-CT) imaging parameters for the response to neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC).

Methods: From January 2016 to March 2020, 52 LARC patients who underwent F-FDG PET-CT scans within 1 week before and 8-9 weeks after nCRT, were enrolled in this study according to a pre-designed screening criteria. After total mesorectal excision (TME) surgery, we assessed tumor response to treatment and analyzed the correlation between imaging parameters obtained from two PET-CT scans and tumor regression status.

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Cancer immunotherapy, including the inhibition of immune checkpoints, improves the tumor immune microenvironment and is an effective tool for cancer therapy. More effective and alternative inhibitory targets are critical for successful immune checkpoint blockade therapy. The interaction of the immunomodulatory ligand B7 family with corresponding receptors induces or inhibits T cell responses by sending co-stimulatory and co-inhibitory signals respectively.

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A 26-year-old woman with pulmonary metastasis of thyroid cancer underwent a total thyroidectomy and cervical lymph node dissection followed by 2 courses of 131I therapy. The posttherapeutic whole-body scan after the second dose of 131I therapy showed diffuse tracer uptake in both lungs. Besides this, there is a local abnormal radiotracer uptake in the left axillary region.

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