Sea anemone peptides represent a valuable class of biomolecules in the marine toxin library due to their various structures and functions. Among these, ShK domain peptides are particularly notable for their selective inhibition of the Kv1.3 channel, holding great potential for applications in immune regulation and the treatment of metabolic disorders.
View Article and Find Full Text PDFRechargeable sodium-chlorine (Na-Cl) batteries show great promise in grid energy storage applications due to their high electrochemical performance. However, the use of highly corrosive thionyl chloride (SOCl)-based electrolytes has severely hindered their real-world applications. Here we show a non-corrosive ester (methyl dichloroacetate) as a promising alternative to SOCl, which can form a non-corrosive electrolyte with aluminum chloride and sodium bis(fluorosulfonyl)imide for high-performance rechargeable Na-Cl batteries.
View Article and Find Full Text PDFBackground: Abnormal lipid profiles are a major risk factor for cardiovascular diseases, and childhood obesity has been linked to changes in lipid metabolism in adults. However, the relationship between childhood obesity and adult lipid profiles, as well as the potential sex differences, remain unclear. This study aimed to examine the association between childhood obesity and abnormal lipid metabolism in young adults, specifically focusing on sex differences.
View Article and Find Full Text PDFPurpose: To determine the occurrence and risk factors of contrast media extravasation (CME) during contrast-enhanced computed tomography (CECT).
Methods: This is an observational retrospective study. 378,082 cases who underwent CECT scans between January 2017 and December 2023 were initially included.
Myocardial DNA damage plays a critical role in the pathogenesis of cardiovascular diseases, frequently leading to adverse outcomes such as myocardial infarction and heart failure. This study elucidated the protective effects of sodium alginate (SA) against myocardial DNA damage and explored the underlying molecular mechanisms involved. Hydrogen peroxide (H₂O₂) -stimulated AC16 cells were employed as an in vitro model to induce myocardial DNA damage, and CCK-8 assays established that SA exhibited no cytotoxicity at concentrations up to 800 µM.
View Article and Find Full Text PDFBisphenols, as a new class of environmental endocrine disruptors (EED), can interfere with the endocrine system of the human body and lead to various diseases. In this study, a novel polyaniline functionalized metal-organic framework (PANI@MIL-101@HF) was synthesized by utilizing hollow fibers (HF) as the the immobilization carrier, and combined with methyl tert-butyl ether (MTBE) for solid-liquid cooperative adsorption to determine bisphenols (BPs) in serum samples. The immobilized adsorbent exhibited excellent high stability and hydrophobicity.
View Article and Find Full Text PDFHydrogel electrolytes are crucial for solving the problems of random zinc dendrite growth, hydrogen evolution reactions, and uncontrollable passivation. However, their complex fabrication processes pose challenges to achieving large-scale production with excellent mechanical properties required to withstand multiple cycles of mechanical loads while maintaining high electrochemical performance needed for the new-generation flexible zinc-ion batteries. Herein, we present a superspreading-based strategy to produce robust hydrogel electrolytes consisting of polyvinyl alcohol, sodium alginate and sodium acetate.
View Article and Find Full Text PDFThe intricate development and functionality of the mammalian heart are influenced by the heterogeneous nature of cardiomyocytes (CMs). In this study, single-cell and spatial transcriptomics were utilized to analyze cells from neonatal mouse hearts, resulting in a comprehensive atlas delineating the transcriptional profiles of distinct CM subsets. A continuum of maturation states was elucidated, emphasizing a progressive developmental trajectory rather than discrete stages.
View Article and Find Full Text PDFPurpose: Intrinsic capacity (IC), a crucial indicator for the United Nations Decade of Healthy Ageing 2021-2030, is defined by WHO as the foundation of functional ability, representing the composite of all physical and mental capacities of an individual. IC spans five function domains: Locomotor, psychological, cognitive, vitality, and sensory (including vision and hearing). Accurate IC assessment is vital for effective interventions, yet comparative analyses of these tools are scarce.
View Article and Find Full Text PDFBackground: Recent advancements in novel anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugates (ADCs) have highlighted the emerging HER2-low breast cancer subtype with promising therapeutic efficacy. This study aimed to comparatively analyze the metabolic characteristics and prognostic stratification of HER2-low and HER2-zero breast cancer using baseline fluorine-18 fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) imaging.
Methods: Consecutive patients with newly diagnosed breast cancer who underwent F-FDG PET/CT prior to therapy in our hospital were retrospectively reviewed.
High strength/toughness nanocomposites are increasingly in demand due to the development needs of high-end applications. However, the aggregation and random orientation of nanofillers and the weak crosslinking of the polymer matrix lead to the degradation of the mechanical properties of nanocomposites. Here, we present a strategy to prepare chitosan-based nanocomposites with aligned nanosheets the photo-crosslinking of modified chitosan.
View Article and Find Full Text PDFPurpose: The goal of this study is to investigate the actor and partner effects of perceived social support and depression in older adults with disabilities and their family caregivers and to investigate the mediating role of resilience in the actor and cross-partner effects of perceived social support on depression.
Methods: We selected 425 pairs of older adults with disabilities and their family caregiver. We used the Resilience Scale, Perceived Social Support Scale, and Patient Health Questionnaire-9 to evaluate them.
Municipal wastewater treatment plants (WWTPs) are important sinks for microplastics, and the vast majority of microplastics entering WWTPs are trapped in residual sludge. In order to investigate the effect of microplastics on anaerobic digestion of sludge, polyethylene terephthalate (PET) microplastics with common particle size and physical aging were selected to conduct a comparative study. Regardless of aging, the addition of 300 and 500 μm PET microplastics inhibited methane production, with their cumulative methane production reduced by 11.
View Article and Find Full Text PDFBackground: Fu Brick tea (FBT) extract has been demonstrated to lower blood lipids, protect liver, and prevent obesity. Despite these benefits, there are no products on the market that combine FBT with other foods or beverages.
Result: In this study, we developed a novel product by combining FBT with high-alcohol Jiang-flavor baijiu, resulting in FBT-baijiu.
Mycotoxins are toxic secondary metabolites produced by various types of fungi that are known to contaminate various food products; their presence in the food chain poses significant risks to human and animal health and leads to enormous economic losses in the food and feed industry worldwide. Ensuring food safety and quality by detoxifying mycotoxin is therefore of paramount importance. Several procedures to control fungal toxins have been extensively investigated, such as preventive measures, physical and chemical methods, and biological strategies.
View Article and Find Full Text PDFDoxorubicin (DOX) is a principal chemotherapeutic agent in the domain of oncological intervention. However, its clinical application is constrained due to its severe and irreversible side effects, particularly heart damage. Ferroptosis, characterized by iron accumulation and redox system imbalance, serves a key role in DOX‑induced cardiotoxicity.
View Article and Find Full Text PDFInt Immunopharmacol
December 2024
Background And Aims: This study focused on the recent advancements in understanding the association between N6-methyladenosine (mA) modification and cardiovascular disease (CVD).
Methods: The potential mechanisms of mA related to CVD were summarized by literature review. Associations between mA levels and CVD were explored across 8 electronic databases: PubMed, Embase, Web of Science, Cochrane Library, Sinomed, Wan Fang, CNKI, and Vip.
Background: Maternal vitamin D deficiency is associated with an increased risk of preeclampsia, a potentially life-threatening multi-system disorder specific to human pregnancy. Placental trophoblast dysfunction is a key factor in the development of preeclampsia, and the activation of NOD-like receptor protein 3 (NLRP3) inflammasome may play a crucial role in this process. Previous studies have suggested that vitamin D can exert beneficial effects by suppressing inflammasome activation, but the underlying mechanism has not been fully elucidated.
View Article and Find Full Text PDFACS Appl Mater Interfaces
October 2024
Apolipoprotein A1 (Apo-A1) is a well-recognized biomarker in tissues, closely associated with cardiovascular diseases such as atherosclerosis, coronary artery disease, and heart failure. However, existing methods for Apo-A1 determination are limited by costly equipment and intricate operational procedures. Given the distinct advantages of electrochemical immunosensors, including affordability and high sensitivity, along with the unique attributes of nanobodies (Nbs), such as enhanced specificity and better tissue permeability, we developed an electrochemical immunosensor for Apo-A1 detection utilizing Nb technology.
View Article and Find Full Text PDFA facile one-pot synthetic method has been developed for constructing 6--spiro[4.5]decane skeletons by merging the ring-opening of benzo[]oxepines and formal 1,2-oxygen migration reactions. More than 30 examples of the 6--spiro[4.
View Article and Find Full Text PDFBenzenoids/phenylpropanoids, the second most diverse group of plant volatiles, exhibit significant structural diversity and play crucial roles in attracting pollinators and protecting against pathogens, insects, and herbivores. This review summarizes their complex biosynthetic pathways and regulatory mechanisms, highlighting their links to plant growth, development, hormone levels, circadian rhythms, and flower coloration. External factors like light, humidity, and temperature also influence their biosynthesis.
View Article and Find Full Text PDFThree new meroterpenoids, asperinsuterpenes A-C (-), and eight previously reported natural products, namely asnovolin I (), (2',4',6')-6-(1'-carboxyocta-2',4',6'-triene)-9-hydroxydrim-7-ene-11,12-olide (), (2',4',6')-6-(1'-carboxyocta-2',4',6'-triene)-11,12-epoxy-9,11-dihydroxydrim-7-ene (), cinereain (), carnequinazolines A and B ( and ), carnemycin B (), and stromemycin () were isolated from the fungus strain BTBU20220155. The structures of the compounds were determined based on spectroscopic techniques, including 1D and 2D NMR, HRESIMS, and ECD experiments. The in vitro antimicrobial evaluation revealed that compounds and exhibited inhibitory activity against , with minimum inhibitory concentration (MIC) values of 12.
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