Large-Scale AI-Based Structure and Activity Prediction Analysis of ShK Domain Peptides from Sea Anemones in the South China Sea.

Sea anemone peptides represent a valuable class of biomolecules in the marine toxin library due to their various structures and functions. Among these, ShK domain peptides are particularly notable for their selective inhibition of the Kv1.3 channel, holding great potential for applications in immune regulation and the treatment of metabolic disorders.

Harnessing organic electrolyte for non-corrosive and wide-temperature Na-Cl battery.

Rechargeable sodium-chlorine (Na-Cl) batteries show great promise in grid energy storage applications due to their high electrochemical performance. However, the use of highly corrosive thionyl chloride (SOCl)-based electrolytes has severely hindered their real-world applications. Here we show a non-corrosive ester (methyl dichloroacetate) as a promising alternative to SOCl, which can form a non-corrosive electrolyte with aluminum chloride and sodium bis(fluorosulfonyl)imide for high-performance rechargeable Na-Cl batteries.

Sex difference in the relationship between childhood obesity and abnormal lipid profiles in young adults.

Background: Abnormal lipid profiles are a major risk factor for cardiovascular diseases, and childhood obesity has been linked to changes in lipid metabolism in adults. However, the relationship between childhood obesity and adult lipid profiles, as well as the potential sex differences, remain unclear. This study aimed to examine the association between childhood obesity and abnormal lipid metabolism in young adults, specifically focusing on sex differences.

Frequency and risk factors of contrast media extravasation in 378,082 intravenous contrast-enhanced CT scans.

Purpose: To determine the occurrence and risk factors of contrast media extravasation (CME) during contrast-enhanced computed tomography (CECT).

Methods: This is an observational retrospective study. 378,082 cases who underwent CECT scans between January 2017 and December 2023 were initially included.

Sodium Alginate Attenuates HO-Induced Myocardial DNA Damage via VSNL1 Regulating the CNP/NPR-B Signaling Pathway.

Myocardial DNA damage plays a critical role in the pathogenesis of cardiovascular diseases, frequently leading to adverse outcomes such as myocardial infarction and heart failure. This study elucidated the protective effects of sodium alginate (SA) against myocardial DNA damage and explored the underlying molecular mechanisms involved. Hydrogen peroxide (H₂O₂) -stimulated AC16 cells were employed as an in vitro model to induce myocardial DNA damage, and CCK-8 assays established that SA exhibited no cytotoxicity at concentrations up to 800 µM.

Enhanced solid-liquid synergistic microextraction of nine bisphenols in serum using polyaniline functionalized metal-organic framework nanocomposites/methyl tert-butyl ether.

Bisphenols, as a new class of environmental endocrine disruptors (EED), can interfere with the endocrine system of the human body and lead to various diseases. In this study, a novel polyaniline functionalized metal-organic framework (PANI@MIL-101@HF) was synthesized by utilizing hollow fibers (HF) as the the immobilization carrier, and combined with methyl tert-butyl ether (MTBE) for solid-liquid cooperative adsorption to determine bisphenols (BPs) in serum samples. The immobilized adsorbent exhibited excellent high stability and hydrophobicity.

Mass production of robust hydrogel electrolytes for high-performance zinc-ion batteries.

Hydrogel electrolytes are crucial for solving the problems of random zinc dendrite growth, hydrogen evolution reactions, and uncontrollable passivation. However, their complex fabrication processes pose challenges to achieving large-scale production with excellent mechanical properties required to withstand multiple cycles of mechanical loads while maintaining high electrochemical performance needed for the new-generation flexible zinc-ion batteries. Herein, we present a superspreading-based strategy to produce robust hydrogel electrolytes consisting of polyvinyl alcohol, sodium alginate and sodium acetate.

Elucidating cardiomyocyte heterogeneity and maturation dynamics through integrated single-cell and spatial transcriptomics.

The intricate development and functionality of the mammalian heart are influenced by the heterogeneous nature of cardiomyocytes (CMs). In this study, single-cell and spatial transcriptomics were utilized to analyze cells from neonatal mouse hearts, resulting in a comprehensive atlas delineating the transcriptional profiles of distinct CM subsets. A continuum of maturation states was elucidated, emphasizing a progressive developmental trajectory rather than discrete stages.

Sensitivity and Specificity of Three Measures of Intrinsic Capacity in Older People Aged 80 and Over in Nursing Homes.

Purpose: Intrinsic capacity (IC), a crucial indicator for the United Nations Decade of Healthy Ageing 2021-2030, is defined by WHO as the foundation of functional ability, representing the composite of all physical and mental capacities of an individual. IC spans five function domains: Locomotor, psychological, cognitive, vitality, and sensory (including vision and hearing). Accurate IC assessment is vital for effective interventions, yet comparative analyses of these tools are scarce.

Comparative analysis of metabolic characteristics and prognostic stratification of HER2-low and HER2-zero breast cancer using F-FDG PET/CT imaging.

Background: Recent advancements in novel anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugates (ADCs) have highlighted the emerging HER2-low breast cancer subtype with promising therapeutic efficacy. This study aimed to comparatively analyze the metabolic characteristics and prognostic stratification of HER2-low and HER2-zero breast cancer using baseline fluorine-18 fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) imaging.

Methods: Consecutive patients with newly diagnosed breast cancer who underwent F-FDG PET/CT prior to therapy in our hospital were retrospectively reviewed.

High strength chitosan-based nanocomposites with aligned nanosheets and crosslinked networks.

High strength/toughness nanocomposites are increasingly in demand due to the development needs of high-end applications. However, the aggregation and random orientation of nanofillers and the weak crosslinking of the polymer matrix lead to the degradation of the mechanical properties of nanocomposites. Here, we present a strategy to prepare chitosan-based nanocomposites with aligned nanosheets the photo-crosslinking of modified chitosan.

The Mediating Role of Resilience between Dyadic Perceived Social Support and Depression at the Older Adults with Disabilities and their Family Caregivers in China: An Actor-Partner Interdependence Model Extended to Mediation.

Purpose: The goal of this study is to investigate the actor and partner effects of perceived social support and depression in older adults with disabilities and their family caregivers and to investigate the mediating role of resilience in the actor and cross-partner effects of perceived social support on depression.

Methods: We selected 425 pairs of older adults with disabilities and their family caregiver. We used the Resilience Scale, Perceived Social Support Scale, and Patient Health Questionnaire-9 to evaluate them.

Impact and mechanism of polyethylene terephthalate microplastics with different particle sizes on sludge anaerobic digestion.

Municipal wastewater treatment plants (WWTPs) are important sinks for microplastics, and the vast majority of microplastics entering WWTPs are trapped in residual sludge. In order to investigate the effect of microplastics on anaerobic digestion of sludge, polyethylene terephthalate (PET) microplastics with common particle size and physical aging were selected to conduct a comparative study. Regardless of aging, the addition of 300 and 500 μm PET microplastics inhibited methane production, with their cumulative methane production reduced by 11.

Effects of fermented tea by Aspergillus cristatus on the characteristic aroma and non-volatile components of Jiang-flavor baijiu.

Background: Fu Brick tea (FBT) extract has been demonstrated to lower blood lipids, protect liver, and prevent obesity. Despite these benefits, there are no products on the market that combine FBT with other foods or beverages.

Result: In this study, we developed a novel product by combining FBT with high-alcohol Jiang-flavor baijiu, resulting in FBT-baijiu.

Mycotoxin Biodegradation by Bacteria-A Review.

Mycotoxins are toxic secondary metabolites produced by various types of fungi that are known to contaminate various food products; their presence in the food chain poses significant risks to human and animal health and leads to enormous economic losses in the food and feed industry worldwide. Ensuring food safety and quality by detoxifying mycotoxin is therefore of paramount importance. Several procedures to control fungal toxins have been extensively investigated, such as preventive measures, physical and chemical methods, and biological strategies.

polysaccharide reduces doxorubicin-induced myocardial ferroptosis injury by activating Nrf2/GPX4 signaling and alleviating iron accumulation.

Doxorubicin (DOX) is a principal chemotherapeutic agent in the domain of oncological intervention. However, its clinical application is constrained due to its severe and irreversible side effects, particularly heart damage. Ferroptosis, characterized by iron accumulation and redox system imbalance, serves a key role in DOX‑induced cardiotoxicity.

The role of mA modification in cardiovascular disease: A systematic review and integrative analysis.

Background And Aims: This study focused on the recent advancements in understanding the association between N6-methyladenosine (mA) modification and cardiovascular disease (CVD).

Methods: The potential mechanisms of mA related to CVD were summarized by literature review. Associations between mA levels and CVD were explored across 8 electronic databases: PubMed, Embase, Web of Science, Cochrane Library, Sinomed, Wan Fang, CNKI, and Vip.

1,25-Dihydroxyvitamin D protects against placental inflammation by suppressing NLRP3-mediated IL-1β production via Nrf2 signaling pathway in preeclampsia.

Background: Maternal vitamin D deficiency is associated with an increased risk of preeclampsia, a potentially life-threatening multi-system disorder specific to human pregnancy. Placental trophoblast dysfunction is a key factor in the development of preeclampsia, and the activation of NOD-like receptor protein 3 (NLRP3) inflammasome may play a crucial role in this process. Previous studies have suggested that vitamin D can exert beneficial effects by suppressing inflammasome activation, but the underlying mechanism has not been fully elucidated.

Ce-MOF@Au-Based Electrochemical Immunosensor for Apolipoprotein A1 Detection Using Nanobody Technology.

Apolipoprotein A1 (Apo-A1) is a well-recognized biomarker in tissues, closely associated with cardiovascular diseases such as atherosclerosis, coronary artery disease, and heart failure. However, existing methods for Apo-A1 determination are limited by costly equipment and intricate operational procedures. Given the distinct advantages of electrochemical immunosensors, including affordability and high sensitivity, along with the unique attributes of nanobodies (Nbs), such as enhanced specificity and better tissue permeability, we developed an electrochemical immunosensor for Apo-A1 detection utilizing Nb technology.

Synthesis of 6--Spiro[4.5]decane Derivatives by Merging Ring-Opening of Benzo[]oxepines and Formal 1,2-Oxygen Migration.

A facile one-pot synthetic method has been developed for constructing 6--spiro[4.5]decane skeletons by merging the ring-opening of benzo[]oxepines and formal 1,2-oxygen migration reactions. More than 30 examples of the 6--spiro[4.

Floral volatile benzenoids/phenylpropanoids: biosynthetic pathway, regulation and ecological value.

Benzenoids/phenylpropanoids, the second most diverse group of plant volatiles, exhibit significant structural diversity and play crucial roles in attracting pollinators and protecting against pathogens, insects, and herbivores. This review summarizes their complex biosynthetic pathways and regulatory mechanisms, highlighting their links to plant growth, development, hormone levels, circadian rhythms, and flower coloration. External factors like light, humidity, and temperature also influence their biosynthesis.

Asperinsuterpenes A-C from the Fungus BTBU20220155.

Three new meroterpenoids, asperinsuterpenes A-C (-), and eight previously reported natural products, namely asnovolin I (), (2',4',6')-6-(1'-carboxyocta-2',4',6'-triene)-9-hydroxydrim-7-ene-11,12-olide (), (2',4',6')-6-(1'-carboxyocta-2',4',6'-triene)-11,12-epoxy-9,11-dihydroxydrim-7-ene (), cinereain (), carnequinazolines A and B ( and ), carnemycin B (), and stromemycin () were isolated from the fungus strain BTBU20220155. The structures of the compounds were determined based on spectroscopic techniques, including 1D and 2D NMR, HRESIMS, and ECD experiments. The in vitro antimicrobial evaluation revealed that compounds and exhibited inhibitory activity against , with minimum inhibitory concentration (MIC) values of 12.