Dehydration-responsive element-binding transcription factor, GuDREB35, positively regulates drought tolerance in licorice (Glycyrrhiza uralensis).

Dehydration-responsive element-binding (DREB) transcription factors associated with abiotic stress responses. However, an understanding of the DREB gene family and its functions in drought tolerance in licorice (Glycyrrhiza uralensis) is limited. In this study, 79 GuDREB genes were identified across the licorice genome and divided into six major groups.

Effects of 15-Day -6° Head-Down Bed Rest and HD-tDCS on Cognitive Functions.

A favorable cognitive state, efficient attention, and sharp alertness are essential for successful space missions. To explore the effects of microgravity on working memory, attention, and alertness and to find effective approaches to improve them, we recruited 17 healthy participants (control: 9, active: 8) to be involved in a 15-day -6° head-down bed rest (HDBR). A 30 min HD-tDCS was applied to the active group every other day during HDBR.

Detection of antidrug antibodies against antibody-drug conjugates by solid-phase extraction with acid dissociation in cynomolgus monkey serum.

The formation of antidrug antibodies (ADAs) against antibody-drug conjugates (ADCs) can trigger a humoral immune response and change drug exposure. Although the immunogenicity assessment of an ADC drug in nonclinical nonhuman primates may not directly translate to potential immunogenicity in humans, the nonclinical ADA assay facilitates understanding the pharmacokinetic profiles of biotherapeutics. The immune response against the human IgG4 monoclonal antibody-based ADC was suspected in cynomolgus monkey serum after intravenous administration at 1.

Assembly and network of et surface microbiome shaped by processing methods and sampling locations.

Objective: et has five types of products, namely, raw rhubarb (RR), wine rhubarb (WR), vinegar rhubarb (VR), cooked rhubarb (CR), and rhubarb charcoal (RC). However, et is easily contaminated with fungi and mycotoxins if not harvested or processed properly. Here, we intend to analyze how microbiome assemblies and co-occurrence patterns are influenced by sampling locations and processing methods.

Enterokinase deficiency associated with novel TMPRSS15 gene mutations: a case report.

Background: Enterokinase deficiency (EKD,OMIM #226200) is a rare autosomal recessive genetic disorder caused by mutations in transmembrane protease serine 15 (TMPRSS15). Herein, we report a case of EKD in a patient with novel compound heterozygous TMPRSS15 mutations.

Case Presentation: A 2-month-old female infant presented with chronic diarrhea, vomiting, pallor, general edema, skin lesions, and a failure to gain weight.

Selective STING Activation in Intratumoral Myeloid Cells via CCR2-Directed Antibody Drug Conjugate TAK-500.

The tumor microenvironment (TME) in solid tumors contains myeloid cells that modulate local immune activity. STING signaling activation in these myeloid cells enhances local type I interferon (IFN) production, inducing an innate immune response that mobilizes adaptive immunity and reprograms immunosuppressive myeloid populations to drive antitumor immunity. Here, we generated TAK-500, an immune cell directed antibody drug conjugate (iADC), to deliver a STING agonist to CCR2+ human cells and drive enhanced antitumor activity relative to non-targeted STING agonists.

Understanding the influence of plant genetic factors on rhizosphere microbiome assembly in .

Introduction: Functional rhizosphere microbiomes (FRM) are critical for plant health and yield. However, the ecological succession of FRM and their links to plant genetic factors across the life cycle of perennial plants remain poorly understood.

Methods: This study profiled FRM, including plant-beneficial bacteria (PBB) and fungal plant pathogens (FPP), across different developmental stages of .

: panoramagram of phytochemical and pharmacological properties, biosynthesis, and regulation and production of ginsenosides.

is a famous perennial herb widely used as material for medicine and health-care food. Due to its various therapeutic effects, research work on has rapidly increased in recent years, urging a comprehensive review of research progress on this important medicinal plant. Here, we summarize the latest studies on the representative bioactive constituents of and their multiple pharmacological effects, like cardiovascular protection, anti-tumor, and immunomodulatory activities.

Spatio-temporal evolution and prediction of carbon balance in the Yellow River Basin and zoning for low-carbon economic development.

Studying the carbon effect of land use in watersheds is important for mitigating global warming, promoting coordinated emission reduction in different regions within the watersheds, and realizing high-quality development of the watersheds. Although a number of scholars have carried out relevant studies in the past, they mainly focused on carbon emissions, rarely involved the carbon balance formed by carbon sources and sinks, and lacked relevant studies on the development of low-carbon economy sub-region. Based on this, this study takes the Yellow River Basin as an example, explores the spatial and temporal evolution of carbon emissions from land use in counties in the Yellow River Basin from 1980 to 2020, and predicts the spatial pattern of carbon income and expenditure from land use under natural conditions in 2030 and 2060 using the PLUS model; and then superimposes on the main functional area planning, divides 735 counties in the Yellow River Basin into six low-carbon economic development subregions, and analyzes their economic development The model of their economic development is analyzed.

Green technology innovation and regional carbon emissions: analysis based on heterogeneous treatment effect modeling.

The impact of green technology innovation on regional carbon emissions has been a contentious issue in academic research. In this study, we attempt to analyze the influence of green technology innovation on regional carbon emissions using panel data from 28 Chinese provinces for the period of 2007-2020. Utilizing a heterogeneous treatment effect model, we systematically examine the effects of green technology innovation on regional carbon emissions.

Fungal microbiome related to mycotoxin contamination in medicinal and edible seed Semen Persicae.

Medicinal and edible seed Semen Persicae is susceptible to mycotoxin and fungal contamination. However, the occurrence of mycotoxin contamination and fungal infection is still unclear. In this paper, ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometry and high-throughput sequencing were conducted to determine the mycotoxin contents and fungal abundances of Semen Persicae.

Generation of an induced pluripotent stem cell line (SDASi001-A) from a Schimke immune-osseous dysplasia patient with SMARCAL1 mutations.

A human induced pluripotent stem cell (iPSC) line (SDASi001-A) was generated from patient with Schimke immune-osseous dysplasia (SIOD), carrying heterozygous mutations in SMARCAL1 gene. Peripheral blood mononuclear cells (PBMCs) were reprogrammed using non-integrating delivery of OCT4, SOX2, KFL4, BCL-XL and c-MYC. The iPSC line expresses pluripotency markers, displays a normal karyotype, and has the ability to differentiate into cells of three germ layers in vitro.

Sampling locations and processing methods shape fungi microbiome on the surface of edible and medicinal Arecae semen.

Introduction: Arecae semen, which is derived from the dried ripe seed of L., has been commonly used as one of the major traditional Chinese medicines (TCMs). Three types of crude herbal preparations, namely, raw Arecae semen (AS), Arecae semen tostum (SAS), and Arecae semen carbonisata (FAS), are available for different clinical applications in TCMs.

Modules in robust but low-efficiency phyllosphere fungal networks drive saponin accumulation in leaves of different Panax species.

Background: The phyllosphere mycobiome plays a crucial role in plant fitness and ecosystem functions. The complex microbial ecological networks (MEN) formed by these fungi remain poorly understood, particularly with regard to their organization strategy and their contributions to plant secondary metabolites such as saponin.

Results: In this study, we constructed six MENs from leaf epiphytic and endophytic mycobiomes of three Panax species distributed in the northeast and southwest ends of mainland China.

Occurrence of fungi and mycotoxins in herbal medicines and rapid detection of toxin-producing fungi.

Contamination from external hazardous materials may greatly influence the safety and efficacy of herbal medicines. This paper aimed to evaluate the levels of contamination by mycotoxins and toxigenic fungi in herbal medicines and establish a rapid method for detecting toxin-producing fungi. Herein, 62.

Jujuboside A ameliorates cognitive deficiency in delirium through promoting hippocampal E4BP4 in mice.

Objective: Delirium (acute brain syndrome) is a common and serious neuropsychiatric disorder characterized by an acute decline in cognitive function. However, there is no effective treatment clinically. Here we investigated the potential effect of jujuboside A (JuA, a natural triterpenoid saponin) on cognitive impairment in delirium.

[Research summary of chemical constituents and pharmacological effects of Panax notoginseng and predictive analysis on its Q-markers].

Panax notoginseng contains triterpene saponins, flavonoids, amino acids, polysaccharides, volatile oil and other active components, which have the effects of promoting blood circulation, stopping bleeding, removing blood stasis, etc. This study summarized the herbal research, chemical constituents and main pharmacological activities of P. notoginseng, and based on the theory of Q-markers of traditional Chinese medicine, predicted and analyzed the Q-markers of P.

Effect of vaginal delivery on adverse pregnancy outcomes after cesarean section in scar uterus.

The purpose of this study was to investigate the impact of vaginal delivery on adverse pregnancy outcomes after cesarean section for the cicatricial uterus. Eighty patients with scarred uterus after cesarean section admitted to our hospital from October 2019 to May 2021 were selected for the study. Among them, 44 cases were eligible for vaginal delivery.