Publications by authors named "Linli Xue"
Background: Prostaglandin E2 (PGE2) is vital for embryo implantation and decidualization. Whether COX2/mPGES1/PGE2 pathway is essential for mouse and human decidualization remains unclear.
Results: This study showed that mPGES1 was highly expressed in the mouse uterus's subluminal stromal cells at the implantation site.
Muscle satellite cells (SCs) play a crucial role in the regeneration and repair of skeletal muscle injuries. Previous studies have shown that myogenic exosomes can enhance satellite cell proliferation, while the expression of miR-140-5p is significantly reduced during the repair process of mouse skeletal muscle injuries induced by BaCl2. This study aims to investigate the potential of myogenic exosomes carrying miR-140-5p inhibitors to activate SCs and influence the regeneration of injured muscles.
View Article and Find Full Text PDFArticle Synopsis
- Numerous studies have highlighted the important role of microRNAs in skeletal muscle development and healing, but the specific functions of miR-222-3p remain largely unclear.
- In experiments, high levels of miR-222-3p in damaged muscle were linked to reduced C2C12 myoblast growth and differentiation, with its inhibition leading to the opposite effects.
- The research identified IRS-1 as a target gene of miR-222-3p and demonstrated that this interaction reduces PI3K-Akt signaling, suggesting miR-222-3p could be a potential therapeutic target for treating muscle loss.
Article Synopsis
- - Obesity leads to chronic inflammation and complications like insulin resistance and type 2 diabetes, prompting the need for new treatments.
- - The study explored how exosomes derived from mouse bone marrow stem cells (BMSC-Exos) can improve metabolic health in obese mice and insulin-resistant fat cells.
- - Treatment with BMSC-Exos enhanced insulin sensitivity and reduced obesity by activating specific cellular pathways that increase glucose uptake.
Small GTPases are signaling molecules in regulating key cellular processes (e.g., cell differentiation, proliferation, and motility) as well as subcellular events (e.
View Article and Find Full Text PDFInvited for this month's cover is the group of Haifeng Xiong at Xiamen University. The image shows that single-atom catalysts can work in the catalytic oxidation of volatile organic compounds. The Review itself is available at 10.
View Article and Find Full Text PDFVolatile organic compounds (VOCs) are detrimental to the environment and human health and must be eliminated before discharging. Oxidation by heterogeneous catalysts is one of the most promising approaches for the VOCs abatement. Precious metal catalysts are highly active for the catalytic oxidation of VOCs, but they are rare and their high price limits large-scale application.
View Article and Find Full Text PDFStimulation of melanin synthesis by UVB is mediated by NO/cGMP/PKG cascade targeting PAK4 in vitro.
In Vitro Cell Dev Biol Anim
March 2021
The coat color of mammals is primarily determined by the type, quantity, and distribution of melanin in the skin and hair. As an endogenous gas molecule, nitric oxide (NO) regulates tyrosinase production by modulating the cGMP-dependent protein kinase (PKG) pathway, which enhances melanin synthesis. However, some interrelationships have not been fully elucidated.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how exosomes and miRNAs, particularly miR-330-5p, regulate pigmentation in skin cells by examining the interactions between keratinocytes (skin cells) and melanocytes (pigment-producing cells).
- Keratinocytes were found to secrete exosomes containing miR-330-5p, which then influenced melanocyte behavior by decreasing melanin production and the expression of the TYR gene, responsible for pigmentation.
- The research highlights a novel mechanism of crosstalk between skin cells that may provide new insights into the regulation of skin pigmentation and potential therapeutic targets.
Article Synopsis
- Tyrosinase-related protein 2 (TRP-2) is crucial for melanin production and varies in expression across different sheep coat colors, including black, white, and piebald.
- The study utilized various scientific methods to analyze TRP-2 levels in sheep and found that darker areas of the coat had higher TRP-2 expression compared to lighter areas.
- The findings suggest that TRP-2 not only influences melanin production but also has potential implications for treating skin diseases linked to pigmentation issues.
Distribution and expression of SLC45A2 in the skin of sheep with different coat colors.
Folia Histochem Cytobiol
April 2017
Introduction: To investigate whether the membrane-associated transporter protein SLC45A2 is differentially expressed in the skin of sheep with different coat colors and to determine its correlation with coat color establishment in sheep.
Material And Methods: The expression of SLC45A2 in sheep skin samples with different coat colors was qualitatively and quantitatively analyzed by PCR amplification, RT-PCR, immunohistochemical staining and Western blotting.
Results: A 193-bp SLC45A2 CDS sequence was successfully amplified from sheep skin samples with diverse coat colors.
Coat color is a key economic trait in wool-producing species. Color development and pigmentation are controlled by complex mechanisms in animals. Here, we report the first production of an altered coat color by overexpression of miR-137 in transgenic mice.
View Article and Find Full Text PDF