Publications by authors named "Linlan Su"
Article Synopsis
- Scientists studied how methamphetamine (METH) affects memory in mice and found it messes with their learning abilities.
- They created models to see how METH changes brain cells and discovered that METH causes inflammation in the brain early on, but this doesn’t get worse with more doses.
- The researchers believe that even though the inflammation might not get worse, certain molecules linked to it stick around and are connected to the mice’s bad behavior, suggesting that treating inflammation could help with problems caused by METH.
Methamphetamine (METH) abuse inflicts both physical and psychological harm. While our previous research has established the regulatory role of miR-29c-3p in behavior sensitization, the underlying mechanisms and target genes remain incompletely understood. In this study, we employed the isobaric tags for relative and absolute quantitation (iTRAQ) technique in conjunction with Ingenuity pathway analysis (IPA) to probe the putative molecular mechanisms of METH sensitization through miR-29c-3p inhibition.
View Article and Find Full Text PDFStructural plasticity changes in the brain are thought to underlie, at least partially, drug-induced persistent changes in behavior. Our previous study reported that increased synaptic density in the nucleus accumbens shell (NAcsh) correlates with and may contribute to behavioral sensitization induced by methamphetamine (METH). However, the distinct changes of dopaminergic and glutamatergic synapses and the modulating effects of dopamine D3 receptor remain unclear.
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