Publications by authors named "Linkui Deng"
Article Synopsis
- * These compounds were tested for antioxidant, anti-tumor, and anti-inflammatory properties, with benzofuran showing notable anti-inflammatory effects, particularly Compound 2 which outperformed a standard drug.
- * The anti-inflammatory action of Compound 2 was studied using network pharmacology, revealing that it works by activating the TLR4/NF-κB pathway, contributing to the understanding of benzofuran glycosides in medicine.*
Objective: Although some studies suggested that metabolic abnormalities may contribute to the development of pulmonary fibrosis, there are no studies that have reported a clear causal relationship between them, and the aim of this study was to explore the causal relationship between plasma metabolites and pulmonary fibrosis using Mendelian randomization (MR) combined with metabolomics analysis.
Methods: Firstly, we explored the causal relationship between 1400 metabolites and pulmonary fibrosis using MR analysis, and detected plasma metabolites in mice with pulmonary fibrosis using metabolomics technology, thus validating the results of MR analysis. In addition, we again used MR to explore the causal relationship between the results of the differential metabolite KEGG in metabolomics and pulmonary fibrosis.