Discovery of potent and selective factor XIa inhibitors incorporating triazole-based benzoic acid as novel P2' fragments: Molecular dynamics simulations and anticoagulant activity.

Factor XIa (FXIa) has emerged as a novel anticoagulant target with a reduced risk of bleeding. However, due to the nearly identical residues it shares with its closest homologue, plasma kallikrein (PKa), only a few selective FXIa inhibitors have been reported. Herein, we describe the discovery of novel triazole-based pyridone derivatives as potent and selective FXIa inhibitors.

Construction of a reaction-based fluorescent sensor for tandem detection of Cu and glutathione in wine.

The purpose of this study was to develop a novel reaction-based fluorescent sensor for the detection of Cu and glutathione in real wine samples. The sensor, tris-(2-pyridyl)-methylamine rhodol derivative, was synthesized and validated for the tandem and selective detection of both Cu and glutathione. The sensor exhibited a strong linear correlation between fluorescence intensity and Cu concentration ranging from 100 to 900 nM, while the in situ generated Cu ensemble selectively detected glutathione with a robust linear response from 3 to 30 μM.