Promoter Methylation-Regulated Differentially Expressed Genes in Breast Cancer.

Background: Breast cancer is one of the most common malignancies among women. Recent studies revealed that differentially methylated regions (DMRs) are implicated in regulating gene expression. The goal of this research was to determine which genes and pathways are dysregulated in breast cancer when their promoters are methylated in an abnormal way, leading to differential expression.

Comparative evaluation of weighted mean and composite score for combining assessments.

Objectives: Approaches for combining scores have been based on weighted mean (WM) without consideration for psychometric characteristics of each individual assessments. This study evaluates consequences of WM and composite score (CS) approach.

Methods: Data from two longitudinal cohorts (n = 219) were utilized for performance in three Operative Dentistry courses as basis to compare the two score-combining methods.

Evaluation of Resin Infiltration, Fluoride and the Biomimetic Mineralization of CPP-ACP in Protecting Enamel after Orthodontic Inter-Proximal Enamel Reduction.

Background: This study investigated the effect of using different agents for protecting enamel proximal surfaces against acidic attack after interproximal reduction (IPR) using the trans micro radiography technique.

Methods: Seventy-five sound-proximal surfaces were obtained from extracted premolars for orthodontic reasons. All teeth were measured miso-distally and mounted before being stripped.

Bonding of Clear Aligner Composite Attachments to Ceramic Materials: An In Vitro Study.

Background: We aim to evaluate the effect of surface conditioning, bonding agents and composite types on surface roughness (SR) and shear bond strength (SBS) of clear aligner composite attachments bonded to ceramics. Methods: One hundred and eighty IPS e.max CAD specimens were prepared.

Adaptational changes in clear aligner fit with time.

Objectives: To analyze adaptational changes in clear aligner fit after intraoral usage at different sets of time.

Materials And Methods: Eight Invisalign appliances (Align Technology, San Jose, California, USA) were collected after intraoral usage. Acrylic imprints of the lower incisor region were constructed for each appliance at T0 (unused appliance).

Morphological evaluation of the incisive canal with reference to gender and age: A cone-beam computed tomography study.

Background: The incisive canal (IC) is an important anatomical structure in the premaxilla that should be considered during many dental procedures.

Aims: The objective of this study is to associate the IC morphology and dimensions with reference to gender and age by means of cone-beam computed tomography (CBCT).

Patients And Methods: A retrospective study was conducted using archived CBCT records of patients who sought treatment at the Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.

Relationship between maxillary central incisors and incisive canal: a cone-beam computed tomography study.

Background: This study aimed to assess the relationship between the maxillary incisors and the incisive canal (IC) using cone-beam computed tomography (CBCT).

Materials And Methods: Archived CBCT scan from 120 subjects (60 males and 60 females, mean age 34.2 ± 13.

Relationship between mandibular symphysis dimensions and skeletal pattern in adults.

Background: The knowledge of dimensions of the symphysis is important for morphological and orthodontic studies. This research evaluates the association between mandibular symphysis dimensions and anteroposterior and vertical skeletal patterns in adults.

Materials And Methods: This cross-sectional cephalometric study included 90 lateral cephalograms of untreated subjects presenting for orthodontic treatment.

E-learning Readiness among Dental Students and Faculty Members Pre-COVID-19 Pandemic.

Purpose: The purpose was to assess students' and faculty readiness toward online dental education in Saudi Arabia.

Materials And Methods: This is a cross-sectional study using a 5-point Likert scale questionnaire distributed to students (undergraduates and postgraduates) and faculty at King Abdulaziz University, Faculty of Dentistry, Jeddah, Saudi Arabia, in 2018. It assessed individual characteristics, system competency needs, social influence, institutional support, overall readiness, and the needed technical support in using e-learning for personal as well as teaching and learning (T&L) purposes.

Mandibular symphysis dimensions in different sagittal and vertical skeletal relationships.

Background: The aim of this cross-sectional study was to compare the dimensions of mandibular symphysis (MS) between gender and the different sagittal and vertical skeletal relationships.

Material And Methods: Pre-treatment records of orthodontic patients were divided according to gender, sagittal (Class I, II and III) and vertical (decreased, average and increased mandibular plane [MP] angle) skeletal relationships. Measurements of MS parameters were performed on lateral cephalograms using IMAGEJ software.

The effect of various mechanical and chemical surface conditioning on the bonding of orthodontic brackets to all ceramic materials.

Background/purpose: Increasing the bond strength between the orthodontic brackets and all-ceramic materials is one of the challenges facing orthodontists. The purpose of this study is to assess the shear bond strength (SBS) of metal brackets to two types of all ceramic materials using various surface mechanical and chemical conditioning methods.

Materials And Methods: Sixty ceramic blocks were prepared using two types of all ceramic materials (IPS e.

Inhibitory effect of Salvadora persica extract (Miswak) on collagen degradation in demineralized dentin: In vitro study.

Background/purpose: Root dentin is vulnerable to acid attack, suggesting a higher risk of demineralization than coronal enamel. This study aimed to evaluate the inhibitory effect of Miswak extract on collagen degradation of demineralized dentin lesion.

Materials And Methods: Demineralized bovine root dentin specimens were treated for 1 h by 20% Miswak extract and 0.

Effect of Extract (Miswak) on the Dentinal Tubules of Sound Root Dentin: Scanning Electron Microscope Study.

Background/purpose: Root dentin is vulnerable to a higher risk of demineralization than coronal enamel. This study aimed to evaluate the effect of miswak extract on the dentinal tubules of sound root dentin.

Materials And Methods: Twenty bovine root dentin blocks, approximately 2 mm × 3 mm × 3 mm (width × length × depth) in dimensions, were prepared from freshly extracted sound bovine incisors.

Young Adults' Preferences and Willingness to Pay for Invasive and Non-invasive Accelerated Orthodontic Treatment: A Comparative Study.

To evaluate the preference of young adult patients and their willingness to pay for the different approaches accessible to accelerate orthodontic tooth movement. A cross-sectional survey was conducted in Jeddah, Saudi Arabia from September to December 2019. Young adult orthodontic patients from 18 to 45 years old were interviewed via online survey regarding their perception to the extent of treatment, acceptability of non-invasive (customized appliances and medications) and invasive (surgery) approaches accessible to accelerate orthodontic treatment and increase in fees they were willing to pay.

Sealants and White Spot Lesions in Orthodontics: A Review.

Aim: This literature review aims to update the evidence for prevention of white spot lesion (WSL) using orthodontic sealants among patients with fixed orthodontic appliances.

Background: As a major issue among orthodontists, prolonged treatment duration increases the risk of plaque development around orthodontic brackets and bands. In consequence, this can lead to heightened risk for caries development and higher possibility of WSL development around fixed orthodontic brackets.

Comparison between Characteristics of Maxillary Right and Left Central Incisors: A Cone-beam Computed Tomography Study.

Aim: To compare the angulation of maxillary left (UL) and right (UR) incisors and the width of alveolar bone.

Materials And Methods: This study was conducted using archived cone-beam computed tomography (CBCT) images of 50 male and 50 female patients. The UL and UR incisors were compared in terms of incisor/palatal plane angle, collum angle, labiopalatal crown-root position, and alveolar bone width (ABW).

Predictive Factors Affecting the Maxillary Alveolar Bone Thickness: A Cone-Beam Computed Tomography Study.

Purpose: Many important structures are associated with the maxillary alveolar bone and should be considered during orthodontic tooth movement. The purpose of this study was to investigate the correlation between the anterior maxillary alveolar bone thickness (AMABT), inclination of the central incisors, and the incisive canal (IC), as well as changes in the thickness based on age and sex of the patients.

Methods: This cross-sectional study was conducted using archived cone-beam computed tomography (CBCT) records categorized according to age and sex.

Prevalence of malocclusion and orthodontic treatment needs among young adults in Jeddah city.

Objective: To assess the prevalence of malocclusion and orthodontic treatment needs in a Saudi sample of Jeddah city.

Materials And Methods: A cross-sectional (descriptive) study was performed in 2017 among 3016 subjects (1507 females and 1509 males) selected according to stratified random sampling design. The inclusion criteria were Saudi students aged between 14-18 years with no craniofacial deformities or syndromes and no orthodontic treatment carried out.

Adult Perceptions of Different Orthodontic Appliances.

Unlabelled: Pursuing an esthetically-pleasing orthodontic outcome, orthodontic patients must consider and choose from the different available options of orthodontic appliance. Practitioners need to be better informed of their customers' preferences to make better practice management decisions and satisfy their patients' needs.

Purpose: To explore adult laypeople's perceptions of the attractiveness, acceptability, preference and economic value of different orthodontic appliances when they consider these appliances for themselves and for their children.

Patients' Perceptions To Reduced Orthodontic Treatment Time In Saudi Arabia.

Purpose: To evaluate patients' perceptions regarding orthodontic treatment duration, cost, and willingness to undergo different procedures and techniques available to accelerate orthodontic tooth movement in Saudi Arabia.

Patients And Methods: A cross-sectional survey was conducted in Saudi Arabia from January to March 2019. Patients from multiple centers were electronically surveyed regarding their perception of orthodontic treatment duration, acceptance of appliances and techniques available to shorten the duration of orthodontic treatment, and how much increase in fees they were willing to pay for those appliances and techniques.

Impact of Dental Visits on Oral Health Awareness in Saudi Arabia.

Aim: The aim of this study is to assess the impact of dental visits on oral health awareness among the Saudi population.

Materials And Methods: A cross-sectional survey was conducted in Saudi Arabia. An online self-administered questionnaire was distributed from January 2011 to June 2013.

Students' perception, attitudes, and readiness toward online learning in dental education in Saudi Arabia: a cohort study.

Purpose: The purpose of this study was to assess students' perception, attitudes, and readiness toward online dental education in Saudi Arabia.

Materials And Methods: This is a longitudinal study using a 5-point Likert scale questionnaire distributed to a cohort group of undergraduate dental students at King Abdulaziz University, Faculty of Dentistry, Jeddah, Saudi Arabia, during their fourth year (T1) and internship year (T2). It assessed technological access, computer skills, online skills, and motivation level in using e-learning for personal and learning purposes; and overall readiness for e-learning adoption in dental education.

Regulation of Lipocalin-2 oncogene and its impact on gene polymorphisms on breast cancer patients in Jeddah, Saudi Arabia.

Objectives: To identify the impact of Lipocalin-2 (LCN2) gene polymorphisms on breast cancer patients in western Saudi Arabia.

Methods: It is a case control study in which blood samples of participants from Medical Reference Clinics and King Abdulaziz University Hospital in Jeddah, Saudi Arabia have been taken between 2014 and 2016. This study recruited 128 participants (50% control, 50% patients) and used Tetra-Primer amplification-refractory mutation system-polymerase chain reaction method for the detection of missense SNP (rs11556770).

Dentoskeletal effects of the forsus™ fatigue resistance device in the treatment of class II malocclusion: A systematic review and meta-analysis.

Objective: The aim of this systematic review and meta-analysis is to quantitatively compare previous studies that evaluated skeletal and dentoalveolar effects of the Forsus™ Fatigue Resistance Device (FRD) in the treatment of Class II malocclusion with a matched untreated control group.

Materials And Methods: Four electronic searches PubMed, Web of Science, Cochrane Library, and Science Direct that were limited to articles on human studies comparing the effect of Forsus appliance with a matched control group in the treatment of Class II malocclusion from the year (2000-2017). An additional manual search was carried out by examining the references of the included articles, SEARCH terms included; Forsus and Class II malocclusion.