Deep removal of trace arsenic from acidic SbCl solution by in-situ galvanically coupled CuSb/Cu particles.

Arsenic is a harmful associated element in antimony ore, which might bring out the risk of leakage during complex industrial production of high-purity antimony. Herein, we reported a novel and efficient way to remove the trace arsenic impurity from acidic SbCl solution by utilizing copper-system bimetallic particles. Specifically, galvanically coupled CuSb/Cu was in-situ synthesized by introducing precursor copper powder to the specific SbCl solution.

Amphiphilic triptycene-based stationary phase for high-resolution gas chromatographic separations.

This work reports a new type of triptycene-based amphiphilic stationary phase (TP-2IL) for gas chromatography (GC). It is an integration of the 3D π-rich triptycene framework with ionic liquids. Its capillary column showed the efficiency of 3880 plates/m determined by n-dodecane at 120 °C (k = 2.

Triptycene-based stationary phases for gas chromatographic separations of positional isomers.

This work presents the investigation of two triptycene-based materials (TP-3OB and TP-3Im) as the stationary phases for gas chromatographic (GC) separations. The TP-3OB and TP-3Im capillary columns fabricated by static coating exhibited column efficiency of 3000-3500 plates/m for n-dodecane at 120 °C. Also, their McReynolds constants and Abraham system constants were determined to characterize their polarity and molecular interactions with analytes.

(-)-Meptazinol-melatonin hybrids as novel dual inhibitors of cholinesterases and amyloid-β aggregation with high antioxidant potency for Alzheimer's therapy.

The multifactorial pathogenesis of Alzheimer's disease (AD) implicates that multi-target-directed ligands (MTDLs) intervention may represent a promising therapy for AD. Amyloid-β (Aβ) aggregation and oxidative stress, two prominent neuropathological hallmarks in patients, play crucial roles in the neurotoxic cascade of this disease. In the present study, a series of novel (-)-meptazinol-melatonin hybrids were designed, synthesized and biologically characterized as potential MTDLs against AD.

Novel bis-(-)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property.

The strategy of dual binding site acetylcholinesterase (AChE) inhibition along with metal chelation may represent a promising direction for multi-targeted interventions in the pathophysiological processes of Alzheimer's disease (AD). In the present study, two derivatives (ZLA and ZLB) of a potent dual binding site AChE inhibitor bis-(-)-nor-meptazinol (bis-MEP) were designed and synthesized by introducing metal chelating pharmacophores into the middle chain of bis-MEP. They could inhibit human AChE activity with IC(50) values of 9.

[Serum levels of pro-inflammatory cytokines in diabetic patients with peripheral neuropathic pain and the correlation among them].

Objective: To investigate the change of serum levels of the pro-inflammatory cytokines: macrophage migration inhibition factor (MIF), tumor necrosis factor-alpha (TNF-alpha), and interleukin 6 (IL-6), in patients with diabetic peripheral neuropathic pain (DPNP) and their role in the pathogenesis of related diseases.

Methods: Peripheral blood samples were collected from 28 patients with diabetes mellitus (DM) without complications, and gender ratio- and age-matched 32 patients with diabetic peripheral neuropathy (DPN), 28 patients with DPNP, and 28 normal controls. Dual-antibody ELISA was used to detect the serum MIF, TNF-alpha, and IL-6 levels.