Optical Diagnosis of Head and Neck Cancers.

Head and neck cancer is one of the most common malignancies. Currently, it has a poor prognosis and significant mortality as the majority of malignancies present in later stages. Early diagnosis affords early intervention and the best chance of cure.

Both central and peripheral auditory systems are involved in salicylate-induced tinnitus in rats: a behavioral study.

Objective: This study was designed to establish a low dose salicylate-induced tinnitus rat model and to investigate whether central or peripheral auditory system is involved in tinnitus.

Methods: Lick suppression ratio (R), lick count and lick latency of conditioned rats in salicylate group (120 mg/kg, intraperitoneally) and saline group were first compared. Bilateral auditory nerves were ablated in unconditioned rats and lick count and lick latency were compared before and after ablation.

The expression of calcitonin gene-related Peptide and acetylcholine in the vestibular-related nucleus population of wild-type mice and retinal degeneration fast mice after rotary stimulation.

Due to the lack of an appropriate animal model, few studies have addressed the integration of visual and vestibular information in the visual system. Using a mouse model with a visual defect (retinal degeneration fast, rdf), we have verified that the prepositus hypoglossal nucleus (PrH) and the Kooy cap of the inferior olive medial nucleus (IOK) are key regions in which visual and vestibular information integrate. Although the integration regions were identified, the precise mechanisms of integration require further investigation.

Clinical trials in chemoprevention of head and neck cancers.

Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies and has significant mortality. Its multi-step cumulative features strongly support early management. Cancer chemoprevention has been accepted as a promising intervention for early management, and has made enormous progresses over the past 30 years due to the large number of research studies including many randomized clinical trials.

A controlled safety study of diindolylmethane in the immature rat model.

Objectives/hypothesis: Diindolylmethane (DIM), a natural product from cruciferous vegetables, has been shown to be a dietary component that has inhibitory effects on some tumors (e.g., laryngeal papilloma).

Fiber-guided CO2 laser surgery in an animal model.

Objective: This study tested a newly developed flexible fiber for CO(2) laser surgery.

Background Data: The lack of a flexible delivery system with the current CO(2) laser has limited its surgical application. We conducted in vitro and in vivo studies by using the skin tissue model of animals to test a new laser fiber system.

Chemopreventive effect of celecoxib in oral precancers and cancers.

Objectives: Oral cancer has become an important health care problem in many countries. Because this disease develops slowly, early detection and intervention can greatly affect ultimate outcome. Celecoxib is a cyclooxygenase-2 inhibitor with significantly less toxicity.

[An experimental study on the therapeutic effects of eustachian tube surfactant in barotitis media].

Objective: To observe the effect of surfactant on eustachian tube (ET) on the opening of ET as well as it's therapeutic role in barotitis media (BM).

Method: 50 guinea pigs were successfully established as BM models by stimulated ascending in altitude chamber. Parts of the models were treated with by middle ear flushing with nature ETS, artificial ETS, artificial phospholipid and saline, after which the eustachian tube pressure opening level (POL) of each group was tested.

Therapeutic effects of eustachian tube surfactant in barotitis media in guinea pigs.

Background: Previous research has shown that the eustachian tube (ET) in animals and humans is lined with a substance that lowers surface tension and thus facilitates the opening of the eustachian tube and aeration of the middle ear. The aims of the present study were to observe the role of eustachian tube surfactant (ETS) on the opening of the ET and to explore the therapeutic effect of natural and artificial ETS on barotitis media (BOM).

Methods: BOM was successfully established in 50 guinea pigs by simulated ascent in an altitude chamber.