6-Phosphogluconate dehydrogenase 2 bridges the OPP and shikimate pathways to enhance aromatic amino acid production in plants.

The oxidative pentose phosphate (OPP) pathway provides metabolic intermediates for the shikimate pathway and directs carbon flow to the biosynthesis of aromatic amino acids (AAAs), which serve as basic protein building blocks and precursors of numerous metabolites essential for plant growth. However, genetic evidence linking the two pathways is largely unclear. In this study, we identified 6-phosphogluconate dehydrogenase 2 (PGD2), the rate-limiting enzyme of the cytosolic OPP pathway, through suppressor screening of arogenate dehydrogenase 2 (adh2) in Arabidopsis.

The Influence of Presentation Frames of Visualization Information for Safety on Situational Awareness under a Three-Level User-Interface Design.

To explore the influence of the construction and presentation frames of visualization information for safety (VIS) on people's situation awareness (SA), we designed a three-level user interface (UI) of VIS based on the three-stage SA theory, including perception (SA1), comprehension (SA2), and projection (SA3). Then, 166 subjects were recruited and divided into three groups to participate in the experiment, in which SA was measured by the situation-present-assessment method (SPAM) and situation-awareness-rating technique (SART), and eye-movement data were recorded. The results show that the level-3 UI design could effectively improve the subjects' SA levels.

Human reliability assessment of intelligent coal mine hoist system based on Bayesian network.

The human reliability of intelligent coal mine hoist operation system is affected by many factors, in order to reduce the occurrence of human error in the hoist system and improve the reliability of the system. The characteristics of phased-mission task operation of hoists is combined, the phase dependence of human cognitive errors is considered and, a new human reliability evaluation method is proposed with the help of Bayesian network (BN) model in this paper. Firstly, the phase dependence of human cognitive errors was analyzed based on the cognitive behavior model.

An Investigation of Employees' Intention to Comply with Information Security System-A Mixed Approach Based on Regression Analysis and fsQCA.

Employee security compliance behavior has become an important safeguard to protect the security of corporate information assets. Focusing on human factors, this paper discusses how to regulate and guide employees' compliance with information security systems through effective methods. Based on protection motivation theory (PMT), a model of employees' intention to comply with the information security system was constructed.

An Investigation of the Effects of Brain Fatigue on the Sustained Attention of Intelligent Coal Mine VDT Operators.

Intelligent mines require much more mental effort from visual display terminal (VDT) operators. Long periods of mental effort can easily result in operator fatigue, which further increases the possibility of operation error. Therefore, research into how brain fatigue affects the sustained attention of VDT operators in intelligent mines is important.

Effect of intracoronary nitroprusside injection on flow recovery during primary PCI in acute STEMI patients.

Background: The no/slow reflow phenomenon during primary percutaneous coronary intervention (PPCI) causes the destruction of the coronary microcirculation and further myocardial damage. Some studies have shown that intracoronary nitroprusside infusion is a safe and effective method for managing the no/slow reflow phenomenon. However, it is uncertain whether the injection of nitroprusside at a specific time point during PPCI can most effectively prevent no-reflow.

Efficacy of combined vancomycin and fosfomycin against methicillin-resistant Staphylococcus aureus in biofilms in vivo.

Infection by methicillin-resistant Staphylococcus aureus (MRSA) is a life-threatening condition, and formation of biofilms can lead to treatment failure in a clinical setting. The aim of this study was to demonstrate the in vivo bactericidal effects of a combination of vancomycin (VAN) and fosfomycin (FOS) against MRSA in a rat carboxymethyl cellulose-pouch biofilm model. The results of the time-kill assay showed that the combination therapy was capable of killing at low minimal inhibitory concentrations (MIC) (½ × MIC VAN +1 × MIC FOS and 1 × MIC VAN + 1 × MIC FOS).

Open achilles tendon defects: a 12-year study on the injury mechanisms, reconstructions, and late complications.

Background: Open injuries of the Achilles tendon, which can be complicated by skin and bone injuries, continue to be a great challenge for surgeons. This study aims to report our experience with treatment of open Achilles tendon defects, focusing on the injury mechanisms, soft tissue coverage and late complications.

Methods: A retrospective review was performed on 31 patients with open Achilles tendon defects between 1999 and 2011.

[Application of computed tomography angiography in visualize of latissimus dorsi myocutaneous flap transplantation].

Objective: To evaluate the feasibility and clinical significance of the computed tomography angiography (CTA) for the latissimus dorsi muscle (LDM) flap transplantation.

Methods: From September 2007 to August 2008, 3 cases of soft tissue defects in limbs were treated with LDM flap transplantation. Three patients included 2 males and 1 female who were 23- to 42-years-old.