ARR1 and AHP interactions in the multi-step phosphorelay system.

Plants use multi-step phosphorelay (MSP) systems in response to exogenous and endogenous stimuli. Cytokinin and ethylene are among the factors that engage MSP signaling cascades but examples independent of phytohormones also exist. The MSP signaling involves four consecutive phosphorylation events at: (i) the kinase domain of the sensory histidine kinase, (ii) the receiver domain of the latter protein, (iii) the histidine-containing phosphotransfer protein, and (iv) the response regulator.

A content review of COVID-19-related apps used in Vietnam.

Introduction: Various digital applications (apps) have been developed as an aid to address the novel issues caused by the Coronavirus disease 2019 (COVID-19) pandemic. Vietnam has experienced a proliferation of apps for this purpose. This review aims to evaluate all Vietnamese COVID-19 apps, analyzing their features, functionality, advantages, disadvantages, and ethical issues to inform developers, communities, and governments on the most desirable features of COVID-19 apps and the user's opinions.

Portable Cell Tracking Velocimetry for Quantification of Intracellular Fe Concentration of Blood Cells.

Hematological analysis is crucial for diagnosing and monitoring blood-related disorders. Nevertheless, conventional hematology analyzers remain confined to laboratory settings due to their high cost, substantial space requirements, and maintenance needs. Herein, we present a portable cell tracking velocimetry (CTV) device for the precise measurement of the magnetic susceptibility of biological entities at the single-cell level, focusing on red blood cells (RBCs) in this work.

A Multicenter Training and Interrater Reliability Study of the BASED Score for Infantile Epileptic Spasms Syndrome.

Purpose: The best possible outcomes in infantile epileptic spasms syndrome require electroclinical remission; however, determining electrographic remission is not straightforward. Although the determination of hypsarrhythmia has inadequate interrater reliability (IRR), the Burden of AmplitudeS and Epileptiform Discharges (BASED) score has shown promise for the reliable interictal assessment of infantile epileptic spasms syndrome. Our aim was to develop a BASED training program and assess the IRR among learners.

Prions in Muscles of Cervids with Chronic Wasting Disease, Norway.

Chronic wasting disease (CWD) is an emerging prion disease in Nordic countries and has been detected in reindeer, moose, and red deer since 2016. CWD sporadically detected in moose and red deer in 3 Nordic countries demonstrated pathologic and strain characteristics different from CWD in reindeer, including an unexpected lack of prions outside the central nervous system as measured by standard diagnostic tests. Using protein misfolding cyclic amplification, we detected prions in the lymphoreticular system of moose and red deer with CWD in Norway and, remarkably, in muscles of both of those species and in CWD-infected reindeer.

Risk association of Lawsonia intracellularis in commercial swine farms.

Lawsonia intracellularis and Brachyspira species are important enteric pathogens in commercial pig farming. Despite their importance, there is little information on the epidemiology and risk factors of these pathogens in Vietnam. Therefore, this study investigated the percentage of L.

Endophytic fungi isolated from Vietnamese nut grass ( L. Cyperaceae) - A promising solution to mitigate the prime phenomenon of antibiotic resistance.

Multidrug resistance in bacteria poses a significant threat to global health, creating an urgent need for new sources of antibiotics. Nut grass or L., a common Asian medicinal herbal remedy, is gaining increasing attention in the scientific community as a potential source of antimicrobial agents.

and microdosimetric study of proton boron capture therapy and neutron capture enhanced proton therapy.

The clinical advantage of proton therapy, compared to other types of irradiations, lies in its reduced dose to normal tissue. Still, proton therapy faces challenges of normal tissue toxicity and radioresistant tumors. To combat these challenges, proton boron capture therapy (PBCT) and neutron capture enhanced particle therapy (NCEPT) were proposed to introduce high-LET radiation in the target volume.

Enhancing the Mechanical and Adhesive Properties of Polyurethane Adhesives with Propylene Oxide-Modified Ethylenediamine (PPO-EDA).

This study explores the use of propylene oxide-modified ethylenediamine (PPO-EDA) as a novel crosslinker and chain extender in polyurethane (PU) adhesives. PPO-EDA was synthesized and compared with ,-dimethylethylenediamine (DMEDA) to assess its impact on mechanical properties and adhesion performance. Key parameters such as NCO conversion, tensile strength, and lap shear strength were thoroughly evaluated.

Modeling Biases from Low-Pass Genome Sequencing to Enable Accurate Population Genetic Inferences.

Low-pass genome sequencing is cost-effective and enables analysis of large cohorts. However, it introduces biases by reducing heterozygous genotypes and low-frequency alleles, impacting subsequent analyses such as model-based demographic history inference. Several approaches exist for inferring an unbiased allele frequency spectrum (AFS) from low-pass data, but they can introduce spurious noise into the AFS.

Recommended Opioid Receptor Tool Compounds: Comparative for Receptor Selectivity Profiles and for Pharmacological Antinociceptive Profiles.

Opioid agonist ligands bind opioid receptors and stimulate downstream signaling cascades for various biological processes including pain and reward. Historically, before cloning the receptors, muscle contraction assays using isolated organ tissues were used followed by radiolabel ligand binding assays on native tissues. Upon cloning of the opioid G protein-coupled receptors (GPCRs), cell assays using transfected opioid receptor DNA plasmids became the standard practice including S-GTPγS functional and cAMP based assays.

Distribution and antifungal susceptibility of species causing vulvovaginal candidiasis and urinary tract infection in Medlatec healthcare system, Ha Noi city, Vietnam in 2023.

Background: Vulvovaginal candidiasis and urinary tract infections caused by are common diseases. While the most common causative agent is , other species, such as non-, can also be responsible. Susceptibility to antifungal drugs varies among species, but there is very limited information available from Vietnam.

Question the promise: validating the interprofessional attitudes scale in Vietnamese health students.

The Interprofessional Attitudes Scale (IPAS) is a promising tool for assessing interprofessional education (IPE) attitudes, especially in community-oriented initiatives. To meet the need for validated IPE tools in Vietnam, we translated the IPAS into Vietnamese (Viet-IPAS) and evaluated its psychometric properties. The preparatory phases included forward and backward translation, expert consultations, and student feedback, resulting in strong content validity, face validity, linguistic comprehensibility, and test-retest reliability.

Development of 6-amido-4-aminoisoindolyn-1,3-diones as p70S6K1 inhibitors and potential breast cancer therapeutics.

Introduction: Many breast cancer therapeutics target the PI3K/AKT/mTOR oncogenic pathway. Development of resistance to the therapeutics targeting this pathway is a frequent occurrence. Therapeutics targeting p70S6K1, a downstream member of this pathway, have recently gained importance due to its critical role in all types of breast cancer and its status as a prognostic marker.

Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders.

Psychiatric disorders pose a significant global health challenge, exacerbated by the COVID-19 pandemic and insufficiently addressed by the current treatments. This review explores the emerging role of bile acids and the TGR5 receptor in the pathophysiology of psychiatric conditions, emphasizing their signaling within the gut-brain axis. We detail the synthesis and systemic functions of bile acids, their transformation by gut microbiota, and their impact across various neuropsychiatric disorders, including major depressive disorder, general anxiety disorder, schizophrenia, autism spectrum disorder, and bipolar disorder.

Assessing the impact of individual exposure to air pollution via biomarkers in sputum of children in Ho Chi Minh city, Vietnam.

Understanding the impact of exposure to air pollution on children's health is critical for developing effective child health protection policies. Alveolar macrophage black carbon (AMBC) provides an indicator of personal exposure to air pollution. Hence, we aimed to examine air pollution exposure and its effects on children by measuring AMBC area and inflammatory cytokines in sputum.

Comparative study of a microdosimetric biological weighting function for RBEmodeling in particle therapy with a solid state SOI microdosimeter.

the recently developed V79-RBEbiological weighting function (BWF) model is a simple and robust tool for a fast relative biological effectiveness (RBE) assessment for comparing different exposure conditions in particle therapy. In this study, the RBEderived by this model (through the particle and heavy ion transport code system (PHITS) simulatedspectra) is compared with values of RBEusing experimentally derivedspectra from a silicon-on-insulator (SOI) microdosimeter.experimentally measuredspectra are used to calculate an RBEvalue utilizing the V79-RBEBWF model as well as the modified microdosimetric kinetic model (MKM) to produce an RBE-vs-trend for a wide range of ions.

Characteristics of a CCL21 Gene-Modified Dendritic Cell Vaccine Utilized for a Clinical Trial in Non-Small Cell Lung Cancer.

The treatment of non-small cell lung cancer has made major strides with the use of immune checkpoint inhibitors; however, there remains a significant need for therapies that can overcome immunotherapy resistance. Dendritic cell (DC) vaccines have been proposed as a therapy that can potentially enhance the antitumor immune response. We have embarked on a phase I clinical trial of a vaccine consisting of monocyte-derived DCs (moDC) modified to express the chemokine C-C motif chemokine ligand 21 (CCL21-DC) given in combination with pembrolizumab.

Innovations in Actinic Keratosis.

This review discusses recent progress in actinic keratosis (AK) management, highlighting therapeutic breakthroughs, pathophysiological discoveries, and program implementation strategies. This article also explores advances in photodynamic therapy, introduces new topical treatments, and details the genomic and transcriptomic pathways from AK to squamous cell carcinoma, including the role of the cutaneous microbiome. Studies aiming to improve diagnosis, adherence, and patient-focused care are also reviewed.

Biofilm formation and drug susceptibility of biofilm spp. clinically isolated from nasopharyngeal cancer patients in Vietnam.

Background And Objectives: The biofilm formation has been widely recognized as one of the main mechanisms of antimicrobial resistance development in microorganisms. However, few studies are focusing on this phenomenon in spp. in clinical settings, especially on immuno-compromised patients.

Verification of linear energy transfer optimized carbon-ion radiotherapy.

Linear energy transfer (LET) verification was conducted using a silicon-on-insulator (SOI) microdosimeter during the commissioning of LET-optimized carbon-ion radiotherapy (CIRT). This advanced treatment technique is expected to improve local control rates, especially in hypoxic tumors.An SOI microdosimeter with a cylindrical sensitive volume of 30m diameter and 5m thickness was used.

Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote OvarianCancer Malignancy.

The accumulation of ascites in patients with ovarian cancer increases their risk of transcoelomic metastasis. Although common routes of peritoneal dissemination are known to follow distinct paths of circulating ascites, the mechanisms that initiate these currents and subsequent fluid shear stresses are not well understood. Here, we developed a patient-based, boundary-driven computational fluid dynamics model to predict an upper range of fluid shear stress generated by the accumulation of ascites.

Reporting ethical approval in case reports and case series in 12 consecutive years: A systematic review.

Our study describes the reported rate of the Institutional Review Board (IRB) approval, declaration of Helsinki (DoH), and informed consent in the case reports and case series and investigates factors associated with the ethical approval report. We searched PubMed for case reports and case series from 2006 to 2017. Annually, we obtained the first 20 articles of a case report cluster from 20 distinct publications.

Effect of Solvent and Cholesterol on Liposome Production by the Reverse-Phase Evaporation (RPE) Method.

Liposomal drug delivery is a promising approach for delivering therapeutics effectively. While most liposomes are designed to be nanometer-sized for efficient cellular uptake, micron-sized liposomes are gaining interest due to their larger drug-loading capacity. When combined with macroscale structures, such as implants and hydrogels, they offer prolonged therapeutic delivery.