Publications by authors named "Linh Tran Nguyen Truc"
Article Synopsis
- * A mouse model, Cd79a-Tsc1 KO, was used to study how mTOR impacts the formation of cysts, showing cyst development by 1 week and full PKD by 4 weeks due to continued cell division.
- * The study suggests that overactivation of mTORC1 interferes with kidney cell morphogenesis and the proper orientation of cell division, hinting at a crucial role of mTOR and cilium signaling in cyst formation.
Article Synopsis
- IgA nephropathy (IgAN) is a common kidney disease with some familial cases, and this study investigates the outcomes of patients with a family history of renal disorders.
- The study followed 467 patients over an average of 8.9 years to compare those with positive family histories (11.6% of the sample) to those without.
- Results indicated that patients with a positive family history had a lower initial kidney function (eGFR) and were at a greater risk for poor outcomes, highlighting familial history as a significant factor in IgAN prognosis.
