Inhibition of pro-inflammatory cytokines by homalolide A and homalomenol A isolated from rhizomes of .

Inflammation, a natural process of the innate immune system, involves elevated levels of various proinflammatory mediators, such as, nitric oxide (NO) and prostaglandin (PGE), cytokines such as interleukin 6 (IL-6), interleukin 10 (IL-10) and tumor necrosis factor alpha (TNF-α), and enzymes including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). This study investigated the anti-inflammatory effects of homalolide A () and homalomenol A (), two sesquiterpenoids isolated from the rhizome of , on lipopolysaccharide (LPS)- stimulated macrophage cells. The results demonstrated that both and dose-dependently inhibited the production of PGE, TNF-α and IL-6 in RAW 264.

Essential Oil from Vietnamese Hook. & Arn. (Piperaceae): Chemical Composition, Antioxidant, Anti-Inflammatory, Cytotoxic Activities, and In Silico Analysis.

This study is the first to investigate the chemical composition and antioxidant, anti-inflammatory, and cytotoxic activities of leaf oil. A yellow oil was obtained through hydro-distillation, with a yield of 0.1% (/).

Conamonin A and dihydrochalcones from the whole plants of Conamomum rubidum (Lamxay & N.S.Lý) Škorničk. & A.D. Poulsen showing anti-inflammatory and cytotoxic activities.

A new compound, conamonin A (), was isolated from the whole plants of with eight known dihydrochalcones (-). Their structures were elucidated by a combination of spectroscopic methods as well as by comparison with previously reported data. The absolute configuration of was assigned by TDDFT-ECD method.

Isolation, structural elucidation, and cytotoxic activity investigation of novel styryl-lactone derivatives from : and studies.

Two styryl-lactone derivatives (1 and 2) were isolated from the aerial parts of . Compound 1 is a newly discovered natural product, and compound 2 is reported in this plant for the first time. The absolute configuration of 1 was determined based on the ECD spectrum.

Structure revision and absolute configuration of 5,7--hydroxyoplopanone and anti-osteoporotic activities of sesquiterpenoids from the rhizomes of .

Five sesquiterpenoids including 2-hydroxyoplopanone , oplopanone (), 1,4,6-trihydroxy-eudesmane (), 1,4,7-trihydroxy-eudesmane () and bullatantriol () were isolated from . The structure of the previously reported compound, 5,7--2-hydroxyoplopanone (), has been revised to by the spectroscopic evidences (1D-/2D-NMR, IR, UV and HRESIMS) and by comparison between experimental and theoretical NMR data using DP4+ protocol. Furthermore, the absolute configuration of was unambiguously assigned by ECD experiments.

Homalolides C-D, two new sesquiterpenoids from the rhizomes of .

Two new sesquiterpenoids, homalolides C - D ‒, were co-isolated from the rhizomes of (Blume) Bakh.f collected in Vietnam with five known ones, aromadendrane-4,10-diol (), bullatantriol (), 1,4,6-trihydroxy-eudesmane (), 1,4,6-trihydroxyeudesmane (), and 1,4,7-trihydroxy-eudesmane (). The structures and relative configuration of new compounds were elucidated by 1 D-/2D-NMR, IR, UV and HRESIMS analyses, and by comparisons to the reported data in the literature.

Sesquiterpenoids from the rhizomes of and their anti-inflammatory activities.

Sixteen sesquiterpenoids including two new ones, homalolides A - B ‒, were firstly isolated from the methanolic extract of the rhizomes of collected in Vietnam. The structures and relative stereochemistry of new compounds were elucidated by 1D-/2D-NMR, IR, UV and HRESIMS analyses. The GCMS experiment demonstrated that homalolide A () is an artifact due to the methylation during methanolic extraction process.