Publications by authors named "Linh T D Pham"
Article Synopsis
- * The study explored the effectiveness of genetic testing, specifically looking at copy number variations (CNVs) in Vietnamese children with ASD, finding a diagnostic success rate of around 6%.
- * Researchers identified 1708 CNVs in total, with 118 being de novo, and highlighted a significant occurrence of deletions in the SHANK3 gene among patients, establishing a basis for developing a CNV-based diagnostic test for ASD in Vietnam.
Background: Approximately 90% of children with cancer live in low-income and middle-income countries (LMICs), where 5-year survival is lower than 20%. Treatment-related mortality in high-income countries is approximately 3-5%; however, in LMICs, treatment-related mortality has been reported in up to 45% of children with cancer. This study aimed to systematically explore the burden of treatment-related mortality in children with cancer in LMICs and to explore the association between country income level and treatment-related mortality.
View Article and Find Full Text PDFBackground: Paediatric early warning systems (PEWS) aid in the early identification of clinical deterioration events in children admitted to hospital. We aimed to investigate the effect of PEWS implementation on mortality due to clinical deterioration in children with cancer in 32 resource-limited hospitals across Latin America.
Methods: Proyecto Escala de Valoración de Alerta Temprana (Proyecto EVAT) is a quality improvement collaborative to implement PEWS in hospitals providing childhood cancer care.
Acidic patch histone mutations and their effects on nucleosome remodeling.
Biochem Soc Trans
April 2022
Structural and biochemical studies have identified a histone surface on each side of the nucleosome disk termed 'the nucleosome acidic patch' that acts as a regulatory hub for the function of numerous nuclear proteins, including ATP-dependent chromatin complexes (remodelers). Four major remodeler subfamilies, SWI/SNF, ISWI, CHD, and INO80, have distinct modes of interaction with one or both nucleosome acidic patches, contributing to their specific remodeling outcomes. Genome-wide sequencing analyses of various human cancers have uncovered high-frequency mutations in histone coding genes, including some that map to the acidic patch.
View Article and Find Full Text PDFArticle Synopsis
- Large-scale genome projects have led to the creation of valuable genetic databases, but Vietnam's genetic studies have mostly relied on data from other populations.
- To address this gap, researchers sequenced and compiled a database of 406 Kinh Vietnamese individuals, identifying nearly 25 million genetic variants.
- This KHV database could enhance genetic research and medical applications for the Vietnamese population and related groups, as it includes many previously unrecognized genetic mutations.