Publications by authors named "Lingyu Yu"
This study compared Ga-FAPI-46 PET/CT, F-fluorodeoxyglucose (FDG) PET/CT, and contrast-enhanced MRI (CE-MRI) for glioma imaging, classification, and recurrence detection and explored PET parameters and molecular pathological profiles. Between June 2020 and June 2024, we prospectively enrolled patients with space-occupying lesions in the brain or previously treated gliomas. All patients underwent sequential CE-MRI, Ga-FAPI-46, and F-FDG PET/CT.
View Article and Find Full Text PDFBACKGROUNDConsidering that trophoblast cell-surface antigen 2 (Trop2) is overexpressed in a wide range of human epithelial cancers, it presents an attractive target for diagnosis and treatment of multiple types of cancer. Herein, we have developed a Trop2-specific radiotracer, 68Ga-MY6349, and present a prospective, investigator-initiated trial to explore the clinical value of 68Ga-MY6349 PET/CT.METHODSIn this translational study, 90 patients with 15 types of cancer who underwent 68Ga-MY6349 PET/CT were enrolled prospectively.
View Article and Find Full Text PDF[Study on the efficacy of posterior cordotomy with partial arytenoidectomy in bilateral vocal fold paralysis].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
October 2024
Article Synopsis
- This study investigates the effectiveness of a specific surgery (posterior cordotomy with partial arytenoidectomy) for patients with bilateral vocal fold paralysis (BVFP).
- The analysis included 37 patients treated between January 2019 and December 2023, focusing on their breathing, voice quality, and swallowing both before and after the surgery.
- Results showed a high success rate in improving breathing (86.5% of patients) but an initial decline in voice quality for the majority post-surgery, with improvements noted by three months, indicating the procedure's overall clinical value despite temporary challenges in voice.
Article Synopsis
- Solitary fibrous tumors (SFTs) are rare fibroblast tumors primarily found in the pleura, with few cases documented involving the liver and bone metastases.
- This study reports a case featuring contrast-enhanced CT and PET/CT imaging, revealing significant findings in a hepatic SFT with skeletal metastases.
- The 68 Ga-FAPI-46 PET/CT scans showed a much clearer contrast in detecting tumors and more metastatic bone lesions compared to the traditional 18 F-FDG PET/CT, indicating its potential advantages in staging malignant SFTs.
Article Synopsis
- Piezoelectric effects, discovered over a century ago, involve materials generating an electric charge in response to mechanical stress.
- These effects have found applications in numerous industries, including electronics, sensors, and medical devices.
- The ongoing research continues to explore innovative uses and improvements in piezoelectric materials and technologies.
Article Synopsis
- This study aimed to investigate the effectiveness of acupuncture in enhancing IVF outcomes for older women with kidney qi deficiency, focusing on metabolic factors in follicular fluid.
- Sixty elderly women undergoing IVF were split into two groups: one receiving acupuncture and ovulation induction, and the other receiving sham acupuncture.
- Results showed improved fertility metrics (higher fertilization and pregnancy rates) in the acupuncture group, along with identified metabolic pathways linked to oocyte development.
Article Synopsis
- - Negative checkpoint regulators (NCRs) like VISTA help control T cell activity to prevent autoimmune diseases by maintaining T cell quiescence and peripheral tolerance.
- - VISTA, which is part of the B7 family, shows promise in treating immune-related diseases such as cancer and autoimmune disorders by modulating immune responses.
- - The review discusses VISTA's potential therapeutic applications, including its current antibody treatments, for managing allergic reactions, autoimmune diseases, and transplant rejection.
Article Synopsis
- A new method for detecting 15 carbonyl compounds in soil was developed using solid phase extraction (SPE) combined with high-performance liquid chromatography (HPLC).
- The process involves extracting samples with acetonitrile, derivatizing them to create stable compounds, and using a specialized SPE cartridge for purification before separation and detection using specific column and wavelength settings.
- The optimized method exhibited high recovery rates, excellent linearity, and better purification efficiency compared to traditional methods, making it effective and reliable for environmental analysis of carbonyl compounds in soil.
Article Synopsis
- Habitual snoring (HS) in children is linked to increased cognitive, behavioral, and sleep-related issues, as reported by their parents.* -
- A study conducted in Chengdu, China surveyed 1,548 children aged 2-14, finding that 30.4% were habitual snorers, with significant associations between snoring frequency and nocturnal symptoms or cognitive and behavioral problems.* -
- The results highlight that children who habitually snore experience more sleep disturbances and daytime challenges compared to occasional snorers and non-snorers, indicating the importance of addressing snoring in pediatric health.*
Efficacy of Acupoint Application on Fertilization Outcome in Patients with Polycystic Ovary Syndrome: A UHPLC-MS-Based Metabolomic Study.
Evid Based Complement Alternat Med
October 2022
Article Synopsis
- The study aimed to assess how acupoint application affects IVF-ET outcomes in patients with PCOS characterized by phlegm-dampness, while also analyzing the metabolic changes in follicular fluid.
- A total of 90 patients were divided into three groups: one receiving acupoint therapy, one without therapy, and a normal group, with metabolic analyses conducted on their follicular fluid.
- Results indicated that the acupoint application group showed metabolic profiles closer to the normal group and identified seven metabolites that were significantly downregulated, suggesting a positive impact on metabolic pathways related to fertility.
Article Synopsis
- Carotid body tumors (CBT) are primarily benign tumors located near the common carotid artery, with very few cases being malignant (MCBT), which can involve cervical lymph node metastasis (CLNM).
- A study reviewed records of 133 CBT patients who underwent surgery, where CLNM was confirmed in 10 cases, mostly affecting middle-aged women, with a follow-up showing a generally good survival rate (9 out of 10).
- The findings indicate that while most CBT patients with CLNM have favorable outcomes, there exist complex associations between clinical features and prognosis, particularly in rare cases of distant metastasis.
Article Synopsis
- Habitual snoring (HS) in children is linked to various risk factors, with a study identifying those factors among children aged 2-14 in Chengdu through parental surveys.
- The research found that 30.4% of the surveyed children were habitual snorers, particularly prevalent in those under 7 years old, and associated with a family history of snoring and various health conditions like allergic rhinitis.
- Key factors contributing to HS included lower breastfeeding duration, maternal education level, and exposure to smoking, while pregnancy complications appeared to reduce the prevalence of snoring in childhood.
Article Synopsis
- Voice disorders in children are common and negatively affect their quality of life, but assessment and therapy are largely unavailable in many pediatric departments in Mainland China.
- A survey of 368 pediatricians in Southwestern China revealed that only a small percentage of children seek help for voice disorders, and fewer than a quarter of hospitals have the necessary equipment for assessment.
- Most pediatricians (74.6%) refer children with dysphonia to otolaryngology, with older and more experienced pediatricians more likely to do so, indicating that experience and hospital quality influence referral practices.
Article Synopsis
- - The study aimed to explore the differences and relationships between the Vocal Fatigue Index (VFI) and the Voice Fatigue Handicap Questionnaire (VFHQ) in individuals with and without voice disorders.
- - Conducted from June to December 2021, the observational study involved 308 participants, revealing that those with voice disorders (primarily chronic laryngitis and vocal fold polyps) experienced worse vocal fatigue and quality of life compared to those without.
- - Results indicated significant differences in VFI and VFHQ scores between groups, with a substantial correlation between the two questionnaires, highlighting that voice disorders are linked to increased vocal fatigue symptoms and a diminished quality of life.
Article Synopsis
- The karyotype of most birds is stable over 100 million years, but parrots show significant chromosomal rearrangements that are not well understood.
- Researchers analyzed four parrot genomes and found frequent chromosome fusions and fissions, primarily occurring independently across different parrot lineages.
- These rearrangements are linked to the loss of two genes that aid in genome stability, and specific changes have led to the formation of neo-sex chromosomes in parrots.
T cell-engaging therapies involving bispecific T cell engager (BiTE) and chimeric antigen receptor T (CAR-T) cells have achieved great success in the treatment of hematological tumors. However, the paucity of ideal cell surface molecules that can be targeted on glioblastoma (GBM) partially reduces the immunotherapeutic efficacy. Recently, high expression of Fn14 has been reported in several solid tumors, so the strategy of exploiting this specific antigen for GBM immunotherapy is worth studying.
View Article and Find Full Text PDFArticle Synopsis
- - Infertility affects many globally, with in vitro fertilization (IVF) being the leading treatment method, although frozen-thawed embryo transfer (FET) shows lower success rates compared to fresh transfers.
- - The study aims to evaluate the Gushen'antai pill (GSATP), a traditional Chinese medicine, in improving pregnancy rates during hormone therapy FET cycles, despite a lack of prior randomized controlled trials on its efficacy.
- - A total of 300 participants, aged 18 to 40 from five hospitals, will be randomly assigned to evaluate the effects of GSATP on pregnancy outcomes, with assessments taking place throughout the gestational period.
Article Synopsis
- - The study aimed to evaluate the effectiveness and reliability of the Mandarin Chinese version of the Voice Fatigue Handicap Questionnaire (MC-VFHQ) among vocal health participants.
- - A total of 358 individuals were tested, including 243 patients with voice disorders and 115 healthy individuals, assessing factors like internal consistency and test-retest reliability, which showed strong results.
- - The MC-VFHQ proved to be a reliable and valid tool for detecting vocal fatigue, with a specific cutoff score of 63.5 and good sensitivity (84.8%) and specificity (84.3%) in distinguishing between patients and healthy individuals.
Article Synopsis
- This study aimed to adapt and validate the Mandarin Chinese version of the pediatric Voice Handicap Index-10 (pVHI-10) to assess the impact of voice disorders in children.
- Conducted from January 2018 to December 2019, the study involved 422 parents, comparing those with children who have voice disorders to those whose children do not.
- Results showed excellent reliability and internal consistency for the adapted version, with significant differences in scores between the two groups, establishing a cut-off value of 6.5 for identifying voice disorders.
Article Synopsis
- A study was conducted on the safety and effectiveness of a surgical procedure called supracricoid partial laryngectomy with cricohyoidoepiglottopexy (SCL-CHEP) for patients with severe laryngeal cicatricial stenosis.
- Sixteen patients were evaluated, resulting in an 81.25% success rate for decannulation, with an average tracheostomy closure time of about 45 days and no significant postoperative complications.
- Improvements in vocal quality scores were observed, and there was no damage to swallowing function, indicating that SCL-CHEP is both effective and safe for treating this condition when patients are carefully selected.
[Treatment efficacy of electronic endoscope-guided botulinum toxin injection in adductor spasmodic dysphonia patients].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
November 2020
Article Synopsis
- The study evaluates the effectiveness of using electronic endoscope-guided botulinum toxin injections for treating patients with Adductor Spasmodic Dysphonia (ASD).
- It analyzed data from 43 ASD patients who underwent the treatment and assessed their voice-related symptoms before and after injection using the Voice Handicap Index-10 (VHI-10) and Visual Analog Scale (VAS).
- Results showed that 35 patients experienced varying improvements in voice symptoms, with significant statistical changes in perceived voice handicap, and no serious side effects were reported.
Article Synopsis
- This study assessed how serum human chorionic gonadotropin (β-hCG) levels on the seventh day post frozen-thawed embryo transfer (FET) can predict pregnancy outcomes, including ongoing and adverse pregnancies.
- Results indicated that higher β-hCG levels were associated with ongoing pregnancies, with specific cut-off levels showing strong predictive values for both single and twin ongoing pregnancies.
- The findings highlight the significance of measuring β-hCG early after FET, as lower levels were linked to adverse outcomes such as ectopic pregnancies and early spontaneous abortions.
Association of TNF-α gene T-1031C polymorphism with endometriosis: A meta-analysis.
Am J Reprod Immunol
December 2020
Article Synopsis
- The T-1031C single nucleotide polymorphism in the TNF-α gene may affect its regulation and could be linked to the development of endometriosis, although the relationship remains unclear.
- A meta-analysis of seven case-control studies evaluated the association between this gene polymorphism and endometriosis, using various statistical models to estimate the strength of these associations.
- The analysis found significant associations in certain populations, indicating that TNF-α T-1031C polymorphism may be associated with endometriosis susceptibility and has a protective effect, particularly in European and Asian groups.
Piezoelectric transducers are convenient enablers for generating and receiving Lamb waves for damage detection. Fatigue cracks are one of the most common causes for the failure of metallic structures. Increasing emphasis on the integrity of critical structures creates an urgent need to monitor structures and to detect cracks at an early stage to prevent catastrophic failures.
View Article and Find Full Text PDFArticle Synopsis
- Extranodal nasal natural killer (NK)/T cell lymphoma (ENKTCL) is a rare, aggressive form of non-Hodgkin lymphoma with low 5-year survival rates, highlighting the urgent need for new treatments.
- Recent research suggests that immunotherapy advancements, particularly using CAR-T cells and BiTE antibodies, may improve treatment options for ENKTCL.
- The study identified high levels of the biomarker B7-H3 in ENKTCL cell lines and developed a new anti-B7-H3/CD3 BiTE antibody and CAR-T cells, which effectively targeted and reduced tumor growth in laboratory models.