Comparative and evolutionary analysis of kinases in immune responses.

The group of receptor-interacting protein (RIP) kinases has seven members (), with one homologous kinase domain but distinct non-kinase regions. Although have emerged as key modulators of inflammation and cell death, few studies have connected to immune responses. The divergence in domain structures and paralogue information in the Ensembl database have raised question about the phylogeny of .

Comprehensive Oncogenic Features of Coronavirus Receptors in Glioblastoma Multiforme.

The COVID-19 pandemic caused by SARS-CoV-2 infection has placed health systems under excessive pressure and especially elderly people with cancer. Glioblastoma multiforme (GBM) is a malignant brain tumor with an increasing incidence in elderly individuals, and thereby GBM patients are a vulnerable population during the COVID-19 outbreak. Accumulating studies have implied that SARS-CoV-2 might invade the brain directly coronavirus receptors.