Disorganization of Small-World Functional Brain Networks in First-Episode, Treatment-Naïve Adolescents With Major Depressive Disorder.

Background And Aims: Adolescent major depressive disorder (MDD) is prevalent globally but often goes unnoticed due to differences in symptoms compared to adult criteria. Analyzing the brain from a network perspective provides new insights into higher-level brain functions and its pathophysiology. This study aimed to investigate changes in the topological organization of functional networks in adolescents with first-episode, treatment-naïve MDD.

Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome.

Brain function relies on efficient communications between distinct brain systems. The pathology of major depressive disorder (MDD) damages functional brain networks, resulting in cognitive impairment. Here, we reviewed the associations between brain functional connectome changes and MDD pathogenesis.

Association between urinary per- and poly-fluoroalkyl substances and COVID-19 susceptibility.

Background And Objective: The growing impact of the COVID-19 pandemic has heightened the urgency of identifying individuals most at risk of infection. Per- and poly-fluoroalkyl substances (PFASs) are manufactured fluorinated chemicals widely used in many industrial and household products. The objective of this case-control study was to assess the association between PFASs exposure and COVID-19 susceptibility and to elucidate the metabolic dysregulation associated with PFASs exposure in COVID-19 patients.