Publications by authors named "Lingyu Dai"
Background: To investigate the associations of methylation, expression, and protein quantitative trait loci (mQTL, eQTL, and pQTL) with ankylosing spondylitis (AS) and find out genetically supported drug targets for AS.
Methods: The summary-data-based Mendelian randomization (SMR) and Bayesian co-localization analysis were used to assess the potential causality between AS and relevant genes. The GWAS data obtained from the International Genetics of Ankylosing Spondylitis Consortium (IGAS) were set as the discovery stage, and the FinnGen and UK Biobank databases were used to replicate the analysis as an external validation.
Background: The application of biologic agents has benefited patients with Behcet's uveitis (BU) who do not respond to conventional treatment regimens. However, there is currently no consensus on the optimal treatment regimen of interferon alpha-2a (IFN-α2a) for refractory BU.
Objectives: To evaluate treatment outcomes and safety of IFN-α2a in a large series of refractory BU patients and to explore whether nonbiologic immunomodulatory agents (cyclosporin A) other than corticosteroids should be concomitantly used.
Sensitive optical coherence tomography angiography parameters detecting retinal vascular changes in Behcet's uveitis.
Photodiagnosis Photodyn Ther
October 2024
Purpose: To compare the retinal parameters in Behcet's uveitis (BU) patients with wide-field swept-source optical coherence tomography angiography (SS-OCTA) and find a sensitive OCTA parameter.
Methods: Fifty-two eyes from 52 quiescent BU patients and 50 healthy eyes were included. All subjects underwent SS-OCTA examinations with 12 × 12 mm region.
Article Synopsis
- The study compared three immunomodulatory therapies—ciclosporin, interferon alfa-2a, and adalimumab—combined with corticosteroids for preventing uveitis relapse in patients with severe Behçet's disease.
- Conducted in a specialized uveitis center in China, the trial involved 270 patients who were randomly assigned to one of the three treatments and the primary outcome measured was the annualized relapse rate of uveitis.
- Results indicated varying efficacy among the treatments, with interferon alfa-2a showing a mean relapse rate of 1.44, suggesting significant differences in how well each therapy works in preventing uveitis symptoms.
Article Synopsis
- The study aimed to evaluate the cost-effectiveness over 26 weeks of two treatments for Vogt-Koyanagi-Harada (VKH) disease: adalimumab combined with corticosteroids (ADA-CS) and cyclosporine with corticosteroids (CSA-CS).
- Results showed that although the ADA-CS treatment was associated with higher costs ($2,497 more than CSA-CS), it offered slightly better quality-adjusted life years (QALYs), with an incremental cost-effectiveness ratio (ICER) of $62,425/QALY for the total participants.
- The analysis suggested that CSA-CS is the more cost-effective first-line treatment option for most patients with VKH, regardless of whether they are in the
Objective: Diagnostic pitfalls often arise in the community because of potentially misleading similarities between juvenile idiopathic arthritis (JIA) and Blau syndrome, an immune-related disorder caused by NOD2 gene mutations. It remains unclear in which population and to what extent next-generation sequencing techniques can aid in diagnosis.
Methods: We evaluated clinical usefulness of targeted next-generation sequencing in previously diagnosed JIA.
Article Synopsis
- Biologics like adalimumab are commonly used for treating Vogt-Koyanagi-Harada disease, but there’s a lack of direct comparisons with traditional immunosuppressants such as cyclosporine.
- In a randomized trial involving 110 patients, the effectiveness of cyclosporine versus adalimumab was measured based on changes in visual acuity over 26 weeks, showing cyclosporine provided better or equivalent results in visual improvement.
- Additionally, the cyclosporine group reported fewer serious adverse events compared to the adalimumab group, indicating a potentially safer therapeutic option for late-phase disease patients.
Importance: Improper host response to COVID-19 vaccines could trigger immune-mediated adverse events. The question remains whether COVID-19 vaccination should be postponed until complete remission in patients with uveitis, a preexisting immune-related condition.
Objective: To compare recommendations for early and deferred COVID-19 vaccination with respect to uveitis outcomes.
Purpose: To investigate vascular changes of fundus in quiescent Behçet uveitis (BU) based on widefield swept source optical coherence tomography angiography and fluorescein angiography (FA).
Method: This case-control study included 33 patients with quiescent BU (57 eyes)and 35 healthy people (60 eyes) as the control. All participants underwent the widefield swept source optical coherence tomography angiography, and patients with BU additionally underwent the FA.
Objectives: Several studies suggested that coronavirus disease 2019 (COVID-19) vaccination may lead to uveitis, a vision-threatening condition often associated with a variety of autoimmune or autoinflammatory diseases. This study aims to explore factors that influence the risk of uveitis relapse after COVID-19 vaccination to guide the prevention of disease.
Methods: Uveitis relapse was evidenced by worsening activity of intraocular inflammation (e.
Objectives: Corticosteroids remain the mainstay of treatment for rheumatic diseases but can cause hepatitis B virus (HBV) reactivation in patients with resolved HBV infection. Risk assessment and stratification are needed to guide the management of these patients before corticosteroid therapy.
Methods: We prospectively enrolled patients with negative hepatitis B surface antigen positive Anti-hepatitis B core status with or without corticosteroid use and determined corticosteroid exposure by calculating cumulative dose and time-weighted average daily dose of prednisone.
Introduction: Immunosuppressive therapy for uveitis may cause liver damage.
Methods: To investigate incidence of liver damage during uveitis treatment, we compared serological Hepatitis B core antibody (HBcAb) status with risk of liver dysfunction in all participants (n = 992), in anterior uveitis (AU) (n = 489), and combined of intermediate, posterior, or panuveitis (IPPU) patients (n = 503). The primary endpoint was incidence of elevated serum alanine aminotransferase level above 2-fold upper limits of normal within 6 months.
Sorption of organochlorine pesticides on polyethylene microplastics in soil suspension.
Ecotoxicol Environ Saf
October 2021
As a new type of environmental pollutant, microplastics (MPs) can adsorb residual organochlorine pesticides (OCPs) in the soil and pose a severe threat to the soil ecosystems. To understand the interaction between soil MPs and OCPs, the sorption of two kinds of OCPs, including hexachlorocyclohexanes (HCHs) and dichlorodiphenyltrichloroethanes (DDTs), on polyethylene (PE) microplastics in soil suspension was studied through sorption kinetics and isotherm models. The effects of solution/soil ratio and MPs diameter on sorption were examined.
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