Case report: Metagenomics next-generation sequencing in the diagnosis of septic shock due to in a 6-year-old child.

() infection is rare in pediatrics. In addition, the detection time of by blood culture is long, and the positive rate is low. Infection with bacilli usually follows rapid disease progression, resulting in high mortality.

Panax notoginseng saponin R1 modulates TNF-α/NF-κB signaling and attenuates allergic airway inflammation in asthma.

Backgroud: Panax notoginseng saponin R1 (PNS-R1) is one of the most important chemical monomers derived from the panax notoginseng, and our previous study found that PNS-R1 reduced glucocorticoid-induced apoptosis in asthmatic airway epithelial cells. Thus, in this study, we explored the effects of the PNS-R1 on inflammation of allergic asthma.

Methods: The asthmatic mice were administered 15 mg/kg PNS-R1 by intraperitoneal injection three days before sensitized to OVA.