rs324015 Gene Polymorphism Increases Ulcerative Colitis Risk: A Case-Control Study.

Introduction: Phosphorylation of signal transducer and activator of transcription 6 (STAT6) in the colonic epithelium is elevated in ulcerative colitis (UC) patients, and its inhibition prevents IL-13-associated apoptosis and barrier disruption. Recently, the rs324015 polymorphism was reported to be related to genetic susceptibility to UC.

Methods: We examined rs324015 using the PCR-RFLP method in 268 UC cases and 357 controls.