Publications by authors named "Lingyi Liang"
Keratoconus is a blinding corneal disorder influenced by genetic factors. Whether environmental factors influence it remains unclear. Here, we observed a U-shaped association between residential greenness and keratoconus, with increased odds ratios (ORs) at low and high greenness levels.
View Article and Find Full Text PDFBackground: This study aimed to characterise imaging artefacts in the lacrimal gland using swept-source optical coherence tomography (SS-OCT) in patients with dry eye disease (DED) and healthy participants and identify risk factors for these artefacts.
Methods: In total, 151 eyes, including 104 from patients with DED and 47 from non-DED participants, were analysed. Demographic data collection, comprehensive ocular examinations and SS-OCT imaging of the palpebral lobe of the lacrimal gland were performed.
Purpose: Cytarabine (Ara-C) chemotherapy causes symptoms resembling meibomian gland dysfunction (MGD), suggesting potential associations between Ara-C and MGD. In this study, the pathological effects of Ara-C on MGD were investigated in a rodent model.
Methods: Mice received Ara-C with or without rosiglitazone (PPARγ agonist) for 7 consecutive days.
Article Synopsis
- The study focuses on Au-MoS nanocomposites, which combine gold nanoparticles with MoS nanosheets to enhance visible-light photocatalytic activity for degrading organic dyes, particularly methylene blue (MB).
- Researchers used a pulsed laser method to create these nanocomposites and examined how varying gold content affects their performance under visible light, revealing that Au NPs improve light absorption and electron transfer.
- The findings highlight that the interaction between positively charged MB and the negatively charged MoS surface, along with the generation of reactive oxygen species, contributes to efficient dye degradation, while also suggesting that the gold contributes to better photocatalytic properties in these nanocomposites.
Article Synopsis
- The study looked at how effective and safe laughter exercises are for people suffering from dry eye disease.
- It was conducted at a big eye clinic in China with participants aged 18-45 who had symptoms of dry eyes.
- Participants were divided into two groups: one did laughter exercises while the other used regular eye drops, and they were monitored for changes in their symptoms over eight weeks.
Reactive oxygen species (ROS) and oxidative stress accelerate cellular aging, but their impact on different tissues varies. The cornea, known for its robust antioxidant defense systems, is relatively resistant to age-related diseases like cancer. However, the precise mechanisms by which the cornea maintains ROS homeostasis during aging remain unclear.
View Article and Find Full Text PDFPurpose: The purpose of this study was to explore the image characteristics of the palpebral lobe of the lacrimal gland in patients with chronic ocular graft-vs-host disease (coGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) using anterior segment optical coherence tomography (AS-OCT).
Methods: This comparative cross-sectional study included 32 patients with coGVHD, 21 patients with severe aqueous tear deficiency dry eye, and 20 healthy control subjects. All subjects underwent an AS-OCT examination on the palpebral lobe of the lacrimal gland.
Purpose: To investigate the delayed diagnosis of chronic ocular graft-versus-host disease (coGVHD) after allogeneic hematopoietic stem cell transplantation (alloHCT), and further analyze potential confounding factors.
Methods: This cross-sectional study included 118 patients newly diagnosed as coGVHD after alloHCT at Zhongshan Ophthalmic Center, Sun Yat-sen University. All participants finished the flow path of medical history taking, detailed ophthalmological examination and questionnaire-based survey.
The accumulation of oleic acid (OA) in the meibum from patients with meibomian gland dysfunction (MGD) suggests that it may contribute to meibomian gland (MG) functional disorder, as it is a potent stimulator of acne-related lipogenesis and inflammation in sebaceous gland. Therefore, we investigate whether OA induces lipogenesis and inflammasome activation in organotypic cultured mouse MG and human meibomian gland epithelial cells (HMGECs). Organotypic cultured mouse MG and HMGECs were exposed to OA or combinations with specific AMPK agonists 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).
View Article and Find Full Text PDFUrban Particulate Matter Triggers Meibomian Gland Dysfunction.
Invest Ophthalmol Vis Sci
February 2024
Purpose: The meibomian gland (MG), as the largest modified sebaceous gland, is potentially damaged by urban particulate matter (UPM) based on epidemiological evidence, but the specific experimental mechanisms remain unknown. This study investigated the effects of UPM on MG dysfunction (MGD) in rodent models.
Methods: Female C57BL/6J mice received eye drops containing UPM suspension or PBS for 14 days.
Purpose: To evaluate the efficacy and safety of intense pulsed light combined with meibomian gland expression (IPL-MGX) for treating meibomian gland dysfunction (MGD) associated with chronic ocular graft-versus-host disease (oGVHD).
Methods: This retrospective study included 18 patients (18 eyes) with Fitzpatrick skin type ≤ IV, who underwent 3 to 8 sessions of IPL-MGX. Dry eye symptomology, ocular surface parameters, and adverse events were evaluated.
Objectives: To investigate the sleep quality in patients with ocular graft-versus-host disease (oGVHD) compared with patients without oGVHD after allogeneic hematopoietic stem cell transplantation (alloHCT) and healthy controls.
Methods: This cross-sectional study analyzed 142 patients after alloHCT including 94 patients with oGVHD and 48 without. Fifty healthy controls were also enrolled.
Alteration of Meibum Lipidomics Profiling in Patients With Chronic Ocular Graft-Versus-Host Disease.
Invest Ophthalmol Vis Sci
September 2023
Purpose: To investigate the characteristics of the lipid profiling in meibum of patients with chronic ocular graft-versus-host disease (coGVHD) and to detect the potential influence of anti-inflammatory therapy on these differential lipids.
Methods: This cross-sectional study included 25 coGVHD patients and 13 non-coGVHD after allogeneic hematopoietic stem cell transplantation. Among those with coGVHD, 14 had prior topical treatment (coGVHD(T)), and 11 did not (coGVHD(WT)).
Purpose: To assess the effect of anti-allergic therapy on sleep quality of children with allergic conjunctivitis (AC) and their parents.
Methods: This prospective single-arm intervention study included 54 AC child-parent dyads. Chinese versions of the Children's Sleep Habits Questionnaire (CSHQ) and Pittsburgh Sleep Quality Index (PSQI) were used to assess the sleep quality of children and their parents, respectively.
Obstruction of the Tear Drainage Altered Lacrimal Gland Structure and Function.
Invest Ophthalmol Vis Sci
July 2023
Article Synopsis
- - The study explores how the obstruction of tear drainage impacts the lacrimal glands (LG), which are crucial for tear production, aiming to uncover the connection between these two parts of the lacrimal system and their roles in ocular surface disorders.
- - Researchers created two mouse models with tear duct obstruction—one surgical and one genetic—and found that both groups displayed similar eye issues like excessive tearing and corneal damage, alongside significant changes in LG cell function and tear composition.
- - The findings indicate that when tear drainage is blocked, it disrupts LG function, highlighting the need to view the lacrimal apparatus as a unified system for better understanding and treatment of eye conditions.
Introduction: The efficacy and safety of 3% diquafosol sodium eye drops in Chinese patients with dry eye in the real-world setting remains unclear.
Methods: 3099 patients with dry eye symptoms were screened according to Asia Dry Eye Society latest recommendation. Among them, 3000 patients were enrolled for a phase IV study.
In this study, we investigated the use of porous silicon (PSi) fabricated using metal-assisted chemical etching (MACE) as a substrate for the deposition of Au nanoparticles (NPs) for the reduction of nitroaromatic compounds. PSi provides a high surface area for the deposition of Au NPs, and MACE allows for the fabrication of a well-defined porous structure in a single step. We used the reduction of -nitroaniline as a model reaction to evaluate the catalytic activity of Au NPs on PSi.
View Article and Find Full Text PDFArticle Synopsis
- * Results showed that T2DM patients had a significantly higher rate and number of Demodex mites, particularly Demodex brevis, and experienced more cylindrical dandruff than the control group.
- * The findings suggest that poor blood glucose control correlates with a greater risk of Demodex infestation in T2DM patients, indicating high blood sugar levels may increase the risk for this skin condition.
Article Synopsis
- Early detection of visual impairment in young children is often overlooked due to their limited ability to cooperate with standard vision tests.
- The Apollo Infant Sight (AIS) is a mobile health system that uses smartphone technology to analyze children's gazing behaviors and facial features to detect 16 different ophthalmic disorders.
- In tests, AIS demonstrated strong performance in identifying visual impairment, achieving high accuracy both in clinical settings and for at-home use by untrained caregivers.
Purpose: To study the posterior segment complications (PSC) and the risk factors in patients after allogeneic hematopoietic stem cell transplantation (HSCT).
Methods: This cross-sectional, case-control study enroled 143 patients who received allogeneic HSCT. Comprehensive ocular examinations were performed to evaluate PSC and ocular Graft-versus-Host Disease (oGVHD).
Background: After allogeneic hematopoietic stem cell transplantation (allo-HSCT), patients are followed up by transplant clinicians. Finding an effective primary screening method that transplant clinicians or patients can master is essential in the early referral of suspected chronic ocular graft-versus-host disease (coGVHD) to an ophthalmologist. This study investigated if the ocular surface disease index (OSDI) questionnaire could be used for coGVHD primary screening.
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