J Colloid Interface Sci
November 2024
Polymer-mediated cytosolic protein delivery demonstrates a promising strategy for the development of protein therapeutics. Here, we propose a new designed diblock copolymer which realizes efficient cytosolic protein delivery both in vitro and in vivo. The polymer contains one protein-binding block composed of phenylboronic acid (PBA) and N-(3-dimethylaminopropyl) (DMAP) pendant units for protein binding and endosomal escape, respectively, followed by the response to ATP enriched in the cytosol which triggers the protein release.
View Article and Find Full Text PDFJ Racial Ethn Health Disparities
October 2024
Physical exercise adherence (PEA) is multifaceted and significantly influenced by elements such as physical prowess, personality traits, psychosocial traits, and demographics. At present, there are problems such as the low degree of PEA in college students. Studies have shown that exercise adherence (EA) can be improved by adjusting psychological factors.
View Article and Find Full Text PDFZhongguo Shi Yan Xue Ye Xue Za Zhi
December 2022
Objective: To study the expression and significance of PD-1, PD-L1 and CTLA-4 tumor-associated antigens in multiple myeloma.
Methods: Bone marrow specimens from 122 patients with multiple myeloma were collected and divided into new-onset group (NDMM), complete remission group (CRMM) and relapsed and refractory group (RRMM) according to the disease progression stage. The proportion of CD4 T lymphocytes, CD8 T lymphocytes, Treg cells and plasma cells in the specimens and the expressions of PD-1, PD-L1 and CTLA-4 were detected by multi-parameter flow cytometry.
Comput Intell Neurosci
September 2022
Health has always been recognized as the imperative parameter to excel in any field whether professional or personal. People with sound health having regular habit of physical activities show more potential in their professional and personal lives than the people who do not participate in the physical activities. Many state-of-the-art studies exist in the literature where researchers have proved the significance of physical activities as supportive treatment for the existing ailments and in improving the overall health of human beings.
View Article and Find Full Text PDFBackground: The genetic changes in chronic myeloid leukaemia (CML) have been well established, although challenges persist in cases with rare fusion transcripts or complex variant translocations. Here, we present a CML patient with e14a3 BCR-ABL1 transcript and t(9;22;12) variant Philadelphia (Ph) chromosome.
Methods: Cytogenetic analysis and fluorescence in situ hybridization (FISH) was performed to identify the chromosomal aberrations and gene fusions.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2011
The study was purposed to detect BAFF/APRIL gene expression changes in bone marrow mononuclear cells (BMMNC) and myeloma cell line U266 after interference with glucocorticoid and bortezomib. After separation of BMMNC from 7 patients with multiple myeloma, BAFF/APRIL mRNA expression in BMMNC and U266 cell line was detected by real-time PCR after treated with dexamethasone 100, 200 µg/ml, methylprednisolone 100, 200 µg/ml, bortezomib 0.1 µg/ml alone and dexamethasone or methylprednisolone combined with bortezomib respectively for 48 hours.
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