Publications by authors named "Lingsheng Jiang"
Hierarchical self-assembly of synthetic polymers in solution represents one of the sophisticated strategies to replicate the natural superstructures which lay the basis for their superb functions. However, it is still quite challenging to increase the degree of complexity of the as-prepared assemblies, especially in a large scale. Liquid-liquid phase separation (LLPS) widely exists in cells and is assumed to be responsible for the formation of many cellular organelles without membranes.
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- Lipid nanoparticles (LNPs) are currently the leading method for delivering mRNA but have drawbacks like multiple components and inflammation-related side effects, which need to be reduced for safety purposes.
- A new series of copolymers called "PHTA" has been developed for mRNA delivery, showing the ability to condense mRNA, improve stability, and extend circulation time without causing significant inflammation.
- The top-performing PHTA-C18 effectively delivers mRNA cancer vaccines in vivo, promoting strong CD8 T cell-mediated antitumor immunity while maintaining a safer inflammatory profile compared to traditional LNPs.
Rechargeable aqueous zinc-ion batteries (ZIBs) have attracted extensive attention due to their low cost and high safety. However, the critical issues of dendrite growth and side reactions on the Zn metal anode hinder the commercialization of ZIBs. Herein, we demonstrated that the formation of ZnSO(OH)·5HO byproducts is closely relevant to the direct contact between the Zn electrode and SO/HO.
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