An electrostatic encapsulation strategy to motivate 3D-printed polyelectrolyte scaffolds for repair of osteoporotic bone defects.

Repair of osteoporotic bone defects (OBD) remains a clinical challenge due to dysregulated bone homeostasis, characterized by impaired osteogenesis and excessive osteoclast activity. While drug-loaded 3D-printed scaffolds hold great potential in the restoration of bone homeostasis for enhanced OBD repair, achieving the controlled release and targeted delivery of drugs in a 3D-printed scaffold is still unmet. Herein, we developed an electrostatic encapsulation strategy to motivate 3D-printed polyelectrolyte scaffolds (APS@P) with bone-targeting liposome formulation of salvianolic acid B (SAB-BTL).

Experience of undergraduate nursing students participating in artificial intelligence + project task driven learning at different stages: a qualitative study.

Background: Artificial intelligence is a growing phenomenon that will soon facilitate wide-scale changes in many professions, and is expected to play an important role in the field of medical education. This study explored the realistic feelings and experiences of nursing undergraduates participating in different stages of artificial intelligence + project task driven learning, and provide a basis for artificial intelligence participation in nursing teaching.

Methods: We conducted face-to-face semi-structured interviews with nursing undergraduates participating in Nursing Research Course which adopts artificial intelligence + project task driven learning from a medical university in Ningxia from September to November 2023, to understand their experience of using artificial intelligence for learning and the emotional changes at different stages.

Alleviation of Glucocorticoid-Induced Osteoporosis in Rats by Ethanolic (Thunb.) Moldenke Extract.

Secondary osteoporosis is frequently due to the use of high-dose glucocorticoids (GCs). The existing strategy for managing glucocorticoid-induced osteoporosis (GIOP) is considered insufficient and remains in a state of ongoing evolution. Therefore, it is crucial to develop more precise and effective agents for the treatment of GIOP.

Metformin attenuates diabetes-induced osteopenia in rats is associated with down-regulation of the RAGE-JAK2-STAT1 signal axis.

Background: Osteopenia and fragile fractures are diabetes-associated complications. Many hypoglycemic drugs have effects on bone metabolism. Metformin, as is a prescribed medication for type 2 diabetes mellitus (T2DM), had been reported to have osteoprotective effects beyond its hypoglycemic effect, however the potential mechanism behind these effects remains unclear.

Association of metformin use with fracture risk in type 2 diabetes: A systematic review and meta-analysis of observational studies.

Aims: Increasing evidence suggests that metformin can affect bone metabolism beyond its hypoglycemic effects in diabetic patients. However, the effects of metformin on fracture risk in type 2 diabetes mellitus (T2DM) patients remain unclear. A systematic review and meta-analysis were performed in this study to evaluate the association between metformin application and fracture risk in T2DM patients based on previous studies published until June 2021.

The impact of climate change on urban resilience in the Beijing-Tianjin-Hebei region.

The increasing uncertainty related to disaster risk under climate change brings about new challenges for sustainable urban management. The emergence of the urban resilience concept can improve the ability and extent to which cities can absorb and resolve risks, providing insight into the sustainable development of cities and regions. Yet, to date, the impact of climate change on regional urban resilience is not well understood.

Inter-provincial sectoral embodied CO net-transfer analysis in China based on hypothetical extraction method and complex network analysis.

To address the CO emissions issue, China promised to increase its nationally determined contributions, trying to reach a CO emissions peak by 2030. For optimizing emission reduction policies, it is important to clarify the CO linkage structure and transfer characteristics. Previous research mainly focused on the calculation and comparison of CO linkage at the national level or the regional level and lacked inter-provincial sector-sector transfer analysis.

Fabrication of Er/Yb Co-Doped BiOI Microsphere With Upconversion Luminescence and Enhanced Photocatalytic Activity for Bisphenol A Degradation.

Er/Yb co-doped BiOI uniform porous microsphere photocatalysts were synthesized by a two-step chemical method, which possesses excellent photocatalytic performance and upconversion luminescence property. The photocatalytic performance of the photocatalysts was studied by degradation of bisphenol A in aqueous solution under visible light and different monochromatic light irradiation. The photocatalytic performance of Er/Yb co-doped BiOI sample is better than that of the pristine BiOI and Er-doped BiOI samples.

Study on industrial selection of counterpart cooperation between Jilin province and Zhejiang province in China from the perspective of low carbon.

Counterpart cooperation is a major innovative measure in China's strategy for revitalizing north-eastern China. While promoting economic progress, regional counterpart cooperation should also focus on low-carbon economy and sustainable development. Under the background of China's proposed innovative cooperation strategy, using a multi-regional input-output (MRIO) model and structural decomposition analysis (SDA), this study takes Jilin province and its counterpart Zhejiang province as an example and decomposes the change in carbon emission intensity (CEI), which is a widely used indicator to measure regional carbon emission performance.

Functional Characterization of New Polyketide Synthase Genes Involved in Ochratoxin A Biosynthesis in Aspergillus Ochraceus fc-1.

Ochratoxin A (OTA), a potentially carcinogenic mycotoxin which contaminates grains, is produced by several Aspergillus species. A comparative sequence analysis of the OTA-producing Aspergillus ochraceus fc-1 strain and other Aspergillus species was performed. Two new OTA-related polyketide synthase (PKS) (AoOTApks) genes were identified.