The global, regional, and national burden of myocarditis in 204 countries and territories, 1990-2021: Results from the Global Burden of Disease Study 2021.

Aims: To estimate the global burden of myocarditis in the general population from 1990 to 2021.

Methods And Results: Data on myocarditis were retrieved from the Global Burden of Disease Study 2021. Incidence, deaths, and disability-adjusted life years (DALYs), along with their age-standardized rates (ASRs) per 100 000 population, were used to measure the burden of myocarditis.

Hybrid Biatrial Ablation Versus Catheter Ablation for Patients With Nonparoxysmal Atrial Fibrillation and Enlarged Left Atrium.

Objective: There is no consensus on the optimal ablation strategy for nonparoxysmal atrial fibrillation (NPAF) with enlarged left atrium. We aimed to explore whether hybrid ablation (HA) of combined thoracoscopic surgical ablation with catheter ablation (CA) was superior to CA alone in these patients.

Methods: Patients with NPAF and left atrial diameter (LAD) ≥45 mm who underwent hybrid biatrial ablation or CA procedure from June 2014 to July 2021 were included in this study.

Machine learning for the prediction of 1-year mortality in patients with sepsis-associated acute kidney injury.

Introduction: Sepsis-associated acute kidney injury (SA-AKI) is strongly associated with poor prognosis. We aimed to build a machine learning (ML)-based clinical model to predict 1-year mortality in patients with SA-AKI.

Methods: Six ML algorithms were included to perform model fitting.

Efficacy of catheter ablation for ventricular tachycardia in ischemic cardiomyopathy patients without an ICD implantation.

Background: The implantable cardioverter-defibrillator (ICD) prevents sudden cardiac death in patients with ischemic cardiomyopathy (ICM). Catheter ablation has been shown to effectively reduce ventricular tachycardia (VT) recurrence, yet its efficacy in patients without an ICD implantation remains uncertain.

Objective: We aimed to investigate the outcomes of ablation for VT in patients with ICM without a backup ICD.

Relationship between stress hyperglycemia ratio and acute kidney injury in patients with congestive heart failure.

Background: The stress hyperglycemia ratio (SHR) has been demonstrated as an independent risk factor for acute kidney injury (AKI) in certain populations. However, this relationship in patients with congestive heart failure (CHF) remains unclear. Our study sought to elucidate the relationship between SHR and AKI in patients with CHF.

U-shaped association between stress hyperglycemia ratio and risk of all-cause mortality in cardiac ICU.

Background: Stress hyperglycemia has been associated with poor prognosis in patients admitted to the cardiac intensive care unit (ICU). Recently, the stress hyperglycemia ratio (SHR) has been proposed to reflect true acute hyperglycemic. This study aimed to investigate the relationship between SHR and prognosis of patients in the cardiac ICU.

Lupeol alleviates autoimmune myocarditis by suppressing macrophage pyroptosis and polarization via PPARα/LACC1/NF-κB signaling pathway.

Background: Autoimmune myocarditis, with increasing incidence and limited therapeutic strategies, is in urgent need to explore its underlying mechanisms and effective drugs. Pyroptosis is a programmed cell death that may contribute to the pathogenesis of myocarditis. Nonetheless, no direct evidence validated the role of pyroptosis in autoimmune myocarditis.

Outcomes of catheter ablation in high-risk patients with Brugada syndrome refusing an implantable cardioverter defibrillator implantation.

Aims: The aim of this study was to investigate the outcomes of catheter ablation (CA) in preventing arrhythmic events among patients with symptomatic Brugada syndrome (BrS) who declined implantable cardioverter defibrillator (ICD) implantation.

Methods And Results: A total of 40 patients with symptomatic BrS were included in the study, of which 18 refused ICD implantation and underwent CA, while 22 patients received ICD implantation. The study employed substrate modification (including endocardial and epicardial approaches) and ventricular fibrillation (VF)-triggering pre-mature ventricular contraction (PVC) ablation strategies.

Melatonin Alleviates Acute Respiratory Distress Syndrome by Inhibiting Alveolar Macrophage NLRP3 Inflammasomes Through the ROS/HIF-1α/GLUT1 Pathway.

Sepsis-induced acute respiratory distress syndrome (ARDS) is a devastating clinically severe respiratory disorder, and no effective therapy is available. Melatonin (MEL), an endogenous neurohormone, has shown great promise in alleviating sepsis-induced ARDS, but the underlying molecular mechanism remains unclear. Using a lipopolysaccharide (LPS)-treated mouse alveolar macrophage cell line (MH-S) model, we found that MEL significantly inhibited NOD-like receptor protein 3 (NLRP3) inflammasome activation in LPS-treated macrophages, whereas this inhibitory effect of MEL was weakened in MH-S cells transfected with glucose transporter 1 (GLUT1) overexpressing lentivirus.

Preparation of polyaluminium silicate sulphate by gravity supercritical method and its coagulation in oily sewage.

In this work, different synthetic methods of polymeric aluminum silicate sulfate (PASS) and their coagulability to oily sewage were comparatively studied. PASS was synthesized by two methods: gravity supercritical method and basic titration method, denoted as PASS-B and PASS-S, respectively. The results show that the PASS prepared by gravity supercritical method has better Alb and stability.

The Prevention and Control Mechanism of Sports Risks in Colleges and Universities under the Background of the Integration of Sports and Education.

Based on the theme of sports risk prevention and control in colleges and universities, the connotation and classification of sports risk in colleges and universities are recognized and screened, the theoretical basis of sports risk prevention and control in colleges and universities is interpreted, and the needs of sports risk prevention and control in colleges and universities are analyzed. On the basis of questionnaire and expert interview, the analytic method is used to construct the evaluation index system of sports risk prevention and control in colleges and universities, including 5 first-level indexes, 9 second-level indexes, and 27 third-level indexes in colleges and universities, teachers, students, parents, and communities, in order to find out the characteristics and occurrence rules of sports risk in colleges and universities in Changsha, Zhuzhou and Xiangtan, Hunan Province. We find out the loopholes and shortcomings in the risk management of sports in colleges and universities and provide theoretical reference for reducing the risk of sports in colleges and universities in the region and improving students' physical quality.

The Deep Integration of China's Regional Ice-Snow Industry and Ecocultural Tourism under the Background of Beijing Winter Olympic Games: Taking Hunan as an Example.

Under the background of the promotion of the Olympic effect of the 2022 Beijing Winter Olympics and the in-depth implementation of the national ice and snow industry's strategy of "expanding from the south to the west and expanding from the east," China's ice and snow industry has ushered in a new period of development. By applying literature and logical analysis, etc., with in-depth analysis of various subjective and objective supplies for the integration of China's ice-snow industry and ecocultural tourism in Hunan Province, it is considered to be driven by the bidding and preparation effect of Beijing Winter Olympic Games in 2022.

Fractal Geometry Illustrated Left Atrial Appendage Morphology That Predicted Thrombosis and Stroke in Patients With Atrial Fibrillation.

Background: This study aims to correlate the morphological complexity of left atrial appendage (LAA) with thrombosis and stroke in patients with atrial fibrillation (AF).

Methods: The training cohort consisted of 46 patients with AF (age 55.8 ± 7.

Cardiac deceleration capacity as an indicator for cardioneuroablation in patients with refractory vasovagal syncope.

Background: Cardioneuroablation is an emerging therapy for refractory vasovagal syncope (VVS), but the standard enrollment criterion is undetermined. Mainstream studies empirically enroll patients with cardioinhibitory and mixed types of VVS on the basis of the head-up tilt (HUT). However, a variety of studies have shown that the results of HUT exhibit unpleasant reproducibility.

Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers: Anti-arrhythmic Drug for Arrhythmogenic Right Ventricular Cardiomyopathy.

Current treatment guidelines for arrhythmogenic right ventricular cardiomyopathy (ARVC) mainly emphasize on prevention of ventricular arrhythmic events. Despite the progressive nature of ARVC, therapeutic options focusing on decelerating disease progression are scarce. This retrospective observational cohort study included 311 patients [age, 39.

The impacts of the ganglionated plexus ablation sequence on the vagal response, heart rate, and blood pressure during cardioneuroablation.

Aims: Cardioneuroablation is an emerging and promising therapy to treat vasovagal syncope (VVS). The aim of this study was to assess the characteristics of vagal response (VR), heart rate (HR), and blood pressure (BP) during cardioneuroablation with different sequences of ganglionated plexus (GPs) catheter ablation and clarify the regulatory mechanism of cardiac GPs of the left atrium.

Methods: A total of 28 patients with VVS who underwent cardioneuroablation were prospectively enrolled and randomly assigned to 2 groups according to the ablation order of GPs.

Clinical Identification and Characteristic Analysis of Giant Cell Myocarditis in 12 Cases.

Giant cell myocarditis (GCM) is a rare, rapidly progressing cardiomyopathy with high mortality, if not diagnosed and treated in time. We analyzed the progression and clinical manifestations of patients with definitive diagnosis of GCM. We enrolled 12 patients diagnosed with GCM in the explanted heart during heart transplantation (HTx) or by endomyocardial biopsy (EMB) and collected information on demographic data, cardiac structure and function, arrhythmias, preliminary diagnosis, and delay of the diagnosis.

Relationship between red blood cell distribution width levels and atrial fibrillation in hypertensive patients.

Background: Information on the relationship between red blood cell distribution width (RDW) and atrial fibrillation (AF) in patients with essential hypertension are scarce. The study aimed to assess the relationship between AF and RDW in hypertensive patients.

Methods: We enrolled 432 hypertensive patients, including 350 AF patients and 82 patients as controls.