The emergence of treatment approaches that integrate conventional phototherapy with additional adjuvant treatments has garnered considerable interest. In this study, we proposed a complex utilizing Fe and polydopamine as a carrier, co-loaded with the nitric oxide initiator L-arginine (L-Arg) and the photosensitizer indocyanine green (ICG), as a potential strategy for the "photothermal/photodynamic/Chemodynamic/nitric oxide gas therapy" of osteosarcoma. Nanoparticles have the ability to undergo degradation within the mildly acidic conditions present in the tumor microenvironment.
View Article and Find Full Text PDFMultidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) is currently recognized not only as a significant nosocomial pathogen but also is an emerging bacterial infection in food-producing animals, posing a critical threat to global health. However, this is a hindrance to detailed bioinformatic studies of MDR A.
View Article and Find Full Text PDFEnzymatic fuel cells (EFCs) are emerging as promising technologies in renewable energy and biomedical applications, utilizing enzyme catalysts to convert the chemical energy of renewable biomass into electrical energy, known for their high energy conversion efficiency and excellent biocompatibility. Currently, EFCs face challenges of poor stability and catalytic efficiency at the cathodes, necessitating solutions to enhance the oriented immobilization of multicopper oxidases for improved heterogeneous electron transfer efficiency. This study successfully identified a surface-binding peptide (SBP, 13 amino acids) derived from a methionine-rich fragment (MetRich, 53 amino acids) in CueO through semirational design.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
December 2024
Nature produces ATP, the energy currency, by converting solar energy (photophosphorylation) and chemical energy (substrate-level phosphorylation and oxidative phosphorylation). Green electricity, as a significant and sustainable energy carrier, plays a crucial role in achieving a carbon-neutral society. In this work, we established and verified a novel electrodriven phosphorylation method.
View Article and Find Full Text PDFIschemia brain injury is closely associated with the gut microbiota. Polysaccharides, as a typical prebiotic, have been extensively employed in stroke treatment. In our previous study, Pueraria lobata polysaccharide (PLP-3) with antioxidant activity was prepared via water extraction and alcohol precipitation combined with ultrasonic degradation.
View Article and Find Full Text PDFSynthesis of microbial fuel cell (MFC) cathode catalysts using corn straw with natural multi-channel structure is an useful measure for developing sustainable energy sources and making creative use of agricultural waste. The catalytic performance of nanomaterial catalysts in the oxygen reduction reaction (ORR) is clearly influenced by porosity and channel structure. Mesopores usually contribute to the enhancement of reaction kinetics and mass transfer.
View Article and Find Full Text PDFThe opioid crisis in Boston necessitated multifaceted prevention strategies. This qualitative descriptive study engaged stakeholders' perspectives to explore the role of community empowerment and educational strategies in opioid overdose prevention. Fifteen officials from law enforcement, healthcare, policy, and community organizations participated in semi-structured interviews conducted from January to March 2024.
View Article and Find Full Text PDFSurface plasmon resonance (SPR) optical fiber sensors are appealing for biomolecular detection due to their inherent characteristics such as flexibility, real-time performance, and high sensitivity. Concurrently, incorporating SPR sensors into wearable devices has emerged as a significant strategy. However, the majority of traditional SPR optical fiber sensors utilize spectrometers for optical readout, which leads to a relatively bulky overall size of the sensing system.
View Article and Find Full Text PDFBackground: T cells have been implicated in various neurological conditions, yet their role in neonatal brain injuries remains unclear. This study aimed to investigate the impact of perinatal factors on frequencies of T cell subsets in preterm infants and to explore the differences in blood genome expression profiles between preterm infants with and without brain injury.
Materials And Methods: Three cohorts of preterm infants were used.
The epidermal growth factor receptor (EGFR) signaling pathway is crucial for skin barrier integrity and immune response. This study explores the impact of EGFR inhibitors, osimertinib and afatinib, on keratinocyte function, focusing on keratin (KRT1, KRT17) and tight junction protein (CLDN1, CLDN2, CLDN4) expression in HaCaT cells. Osimertinib significantly increased the mRNA and protein levels of keratins and inflammatory markers, IL-6 and TNF-α, via activation of the EGFR-STAT3 signaling pathway.
View Article and Find Full Text PDFIntroduction: In recent years, an increasing body of research has illustrated a strong correlation between gut microbiota and depression. However, there has yet to be a comprehensive discussion or summary of the latest advancements and trends in this field.
Methods: We retrieved research articles focused on gut microbiota and depression through the WOS database from 2020 to 2024, using visual text analysis tools such as CiteSpace and VOSviewer.
Chemical conversion has emerged as an effective approach for disposing waste plastics; however, the product diversity in traditional methods leads to pressing challenges in product separation and purification. As a pioneering advancement, the comprehensive transformation of waste plastics into CH presents an attractive prospect: directly yielding high-purity products. Significantly, CH is an important hydrogen carrier and an industrial feedstock.
View Article and Find Full Text PDFElectrocatalytic carbon dioxide (CO) reduction by CO reductases is a promising approach for biomanufacturing. Among all known biological or chemical catalysts, hydrogen-dependent carbon dioxide reductase from Thermoanaerobacter kivui (TkHDCR) possesses the highest activity toward CO reduction. Herein, we engineer TkHDCR to generate an electro-responsive carbon dioxide reductase considering the safety and convenience.
View Article and Find Full Text PDFPurpose: Cervical cancer (CC), a significant global health threat, necessitates comprehensive understanding for improved therapeutic interventions. Many research indicates that dysregulation of the Hippo-YAP1 pathway leads to uncontrolled proliferation and invasion of tumor cells, promoting the progression of various cancers. This article aims to elucidate the role of RNF6 in CC and its regulation of the Hippo-YAP1 signaling pathway.
View Article and Find Full Text PDFBackground: Burns are a global health issue causing significant mortality and high medical costs. Non-pharmacological interventions such as music therapy and virtual reality (VR) therapy have shown potential in alleviating pain and anxiety in burn patients. This study systematically evaluates the impact of these interventions using a network meta-analysis.
View Article and Find Full Text PDFMollusca represents the second-largest animal phylum but remains less explored genomically. The increase in high-quality genomes and diverse functional genomic data holds great promise for advancing our understanding of molluscan biology and evolution. To address the opportunities and challenges facing the molluscan research community in managing vast multi-omics resources, we developed MolluscDB 2.
View Article and Find Full Text PDFPost-stroke depression (PSD) is a common but severe mental complication after stroke. However, the cellular and molecular understanding of PSD is still yet to be illustrated. In current study, we prepared PSD rat model (MD) via unilateral middle cerebral artery occlusion (MCAO) and chronic stress stimulation (DEPR), and isolated hippocampal tissues for single cell sequencing of 10x Genomics Chromium.
View Article and Find Full Text PDFBackground: While TB-related mortality in the US declined four-fold from 1990 to 2019, country-level estimates of TB burden obscure within-state racial heterogeneity and changes in TB burden over time. In sixteen US Southern States and Washington DC, the effects of health inequities engendered by Jim-Crow laws enacted from the late 1800s to the 1960s have not been evaluated for TB-related mortality. We, therefore, sought to compare TB mortality rates and annualized rate of change (AROC) between 1990 and 2019 in former Jim-Crow vs.
View Article and Find Full Text PDFThe bioadhesive hydrogels have been viewed as promising substitutes for surgical sutures in wound closure. However, current bioadhesives face challenges such as weak wet adhesion and hemostatic performance, which hinder their wider clinical application. In this study, a novel poly(thioctic acid)Li/caffeic acid-grafted sericin (CAS) (PTALi-CAS) supramolecular hydrogel was prepared using facile one-pot method.
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