TEDML: a new machine learning (ML) approach for predicting thyroid eye disease and identifying key biomarkers.

Thyroid eye disease (TED) features immune infiltration and metabolic dysregulation. Understanding these processes and identifying potential biomarkers are crucial for improving diagnosis and treatment. To this end, immune cell infiltration was analyzed and gene set variation analysis (GSVA) was conducted on the GSE58331 dataset to identify differences between TED and normal tissues.

Protraction of a second molar and a mesially-impacted third molar into the adjacent first-molar extraction site through mini-implant anchored Albert protraction loop with the aid of alveolar ridge augmentation.

Protraction of a mandibular second molar to substitute the adjacent missing first molar is challenging in clinical practice. In this case report, we demonstrated a 21-year-old patient with an untreatable periapical lesion of the mandibular right first molar. The adjacent mandibular second molar had normal root length and the third molar was mesially-impacted.

Propolis does not significantly modulate immune function in an older population: A preliminary study.

Purpose: The human trial aimed to study the influence of propolis on immune function in the elderly.

Methods: Non-institutionalized community-dwelling individuals aged 60-80 years were recruited from Tianjin, China. Participants were assigned randomly to either the Chinese propolis group (600 mg/day, n = 32) or the control group (n = 30).

The therapeutic potential of Osmundacetone for rheumatoid arthritis: Effects and mechanisms on osteoclastogenesis.

The present study aimed to investigate the therapeutic potential of Osmundacetone (Osu), a natural plant product, for the treatment of rheumatoid arthritis (RA). The study revealed that Osu effectively reduced arthritis-induced swelling and bone destruction, as well as alleviating inflammation-related factors and oxidative stress in animal models. We focused the mechanism exploration on its regulatory mechanism on osteoclastogenesis in the next investigation.

Orthodontic traction of a deeply impacted mandibular first molar via a ramus miniscrew through lateral-window technique: A case report.

Background: The incidence of mandibular first molar impaction is less than 0.01%, and there are no standard treatment guidelines. Orthodontic traction can be chosen as a treatment plan in some circumstances.

Intermittent high altitude hypoxia induced liver and kidney injury leading to hyperuricemia.

About 140 million people worldwide live at an altitude above 2500 m. Studies have showed an increase of the incidence of hyperuricemia among plateau populations, but little is known about the possible mechanisms. This study aims to assess the effects of high altitude on hyperuricemia and explore the corresponding mechanisms at the histological, inflammatory and molecular levels.

SIRT1 regulates mitochondrial fission to alleviate high altitude hypoxia inducedcardiac dysfunction in rats via the PGC-1α-DRP1/FIS1/MFF pathway.

High-altitude exposure has been linked to cardiac dysfunction. Silent information regulator factor 2-related enzyme 1 (sirtuin 1, SIRT1), a nicotinamide adenine dinucleotide-dependent deacetylase, plays a crucial role in regulating numerous cardiovascular diseases. However, the relationship between SIRT1 and cardiac dysfunction induced by hypobaric hypoxia (HH) remains unexplored.

Corrigendum: Sestrin2 protects against hypoxic nerve injury by regulating mitophagy through SESN2/AMPK pathway.

[This corrects the article DOI: 10.3389/fmolb.2023.

Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.

An excess of osteoclastogenesis significantly contributes to the development of rheumatoid arthritis (RA). Activation of the nuclear factor erythroid-2 related factor 2 (Nrf2) and nuclear factor kappa B (NF-κB) ligand (RANKL)-induced reactive oxygen species (ROS)-to-NF-κB signaling cascade are important mechanisms regulating osteoclastogenesis; however, whether Nrf2 is involved in RANKL-induced NF-κB activation is controversial. Isoquercitrin, a natural flavonoid compound, has been shown to have Nrf2-dependent antioxidant effects inprevious studies.

Sestrin2 protects against hypoxic nerve injury by regulating mitophagy through SESN2/AMPK pathway.

Hypoxia induced by high altitude can lead to severe neurological dysfunction. Mitophagy is known to play a crucial role in hypoxic nerve injury. However, the regulatory mechanism of mitophagy during this injury remains unclear.

LAMC2 regulates proliferation, migration, and invasion mediated by the Pl3K/AKT/mTOR pathway in oral.

Background: Oral squamous cell carcinoma (OSCC) is a common malignant tumor. Recently, Laminin Gamma 2 (LAMC2) has been shown to be abnormally expressed in OSCC; however, how LAMC2 signaling contributes to the occurrence and development of OSCC and the role of autophagy in OSCC has not been fully explored. This study aimed to analyze the role and mechanism of LAMC2 signaling in OSCC and the involvement of autophagy in OSCC.

Citrus tangerine pith extract alleviates hypoxia-induced ileum damage in mice by modulating intestinal microbiota.

Visitors to high altitude are susceptible to hypoxia-induced acute intestinal mucosal barrier injury and severe gastrointestinal disorders, which are life-threatening. Citrus tangerine pith extract (CTPE) is rich in pectin and flavonoids and has been proved to enhance intestinal health and improve gut dysbiosis. In this study, we aim to explore the protective effect of CTPE on ileum injury induced by intermittent hypobaric hypoxia in a mouse model.

[Resveratrol attenuates cardiac function impairment in plateau hypobaric hypoxia rats].

To study the protective effects of resveratrol (RSV) on cardiac function in rats with high altitude hypobaric hypoxia and its mechanisms. Thirty-six rats were randomly divided into control group, hypobaric hypoxia group (HH) and hypobaric hypoxia + RSV group (HH+RSV) according to the random number, 12 rats in each group. Rats in the HH and HH+RSV groups were subjected to chronic long-term high altitude hypobaric hypoxia intervention for 8 weeks in a hypobaric chamber at a simulated altitude of 6 000 m for 20 h / d.

Optimal sites and angles for the insertion of orthodontic mini-implants at infrazygomatic crest: a cone beam computed tomography (CBCT)-based study.

Background And Objectives: Both cortical and overall bone thicknesses of the infrazygomatic crest (IZC) were measured to determine the optimal areas for mini-implants into the IZC. The impact of insertion sites, heights and angles, sex and age on bone thickness were evaluated.

Materials And Methods: In this study, cone beam computed tomography (CBCT) images of 32 patients were included.

The predictability of orthodontic tooth movements through clear aligner among first-premolar extraction patients: a multivariate analysis.

Background: The purpose was to determine the predictability of tooth movements through clear aligner among premolar extraction patients and to explore the effects of various factors on tooth movements.

Methods: A total of 31 extraction patients (10 males and 20 females; age 14-44) receiving clear aligner treatment (Invisalign) were enrolled in this study. The actual post-treatment models and pre-treatment models were superimposed using the palatal area as a reference and registered with virtual post-treatment models.

Is the response rate of oral appliance therapy for subjects with and without position-dependent obstructive sleep apnoea different?

Objective To compare the effect of oral appliance (OA) treatment on non-position-dependent obstructive sleep apnoea (non-POSA) and position-dependent obstructive sleep apnoea (POSA).Methods The investigational sample was 205 patients with obstructive sleep apnoea at baseline and they were classified as non-POSA and POSA. Polygraphic registration was employed to compare the proportion of treatment responders between non-POSA and POSA groups at eight-week and one-year follow-ups.

[Construction and evaluation of a gradient stress model of PC12 cells induced by corticosterone].

A gradient stress model of PC12 cells induced by corticosterone was established to provide a basis for the evaluation and regulation of cell stress. The effect of corticosterone on cell viability was observed by measuring PC12 cell viability at different concentrations of corticosterone (0~1 000 μmol/L) after different intervention times (8~48 h) to screen the cell models for optimal intervention conditions. Key stress indicators (MDA, SOD, NADH, LDH) were measured spectrophotometrically and microscopically to evaluate the models.

Orthodontic traction of an impacted maxillary third molar through a miniscrew-anchored cantilever spring to substitute the adjacent second molar with severe root resorption.

Background: An orthodontic traction technique with a miniscrew-anchored cantilever spring was used for the traction of a deeply impacted maxillary third molar to substitute its adjacent second molar with severe root resorption.

Case Description: A 30-year-old woman sought multidisciplinary treatment planning for a second molar with severe root resorption caused by a deeply impacted third molar. Panoramic radiographs and cone-beam computed tomographic images showed that the third molar was located on the apical and palatal side of the second molar and that the second molar had severe root resorption.

Development of an Artificial Intelligence System for the Automatic Evaluation of Cervical Vertebral Maturation Status.

Background: Cervical vertebral maturation (CVM) is widely used to evaluate growth potential in the field of orthodontics. This study is aimed to develop an artificial intelligence (AI) system to automatically determine the CVM status and evaluate the AI performance.

Methods: A total of 1080 cephalometric radiographs, with the age of patients ranging from 6 to 22 years old, were included in the dataset (980 in training dataset and 100 in testing dataset).

An NADH-selective and sensitive fluorescence probe to evaluate living cell hypoxic stress.

Cellular disease and senescence are often accompanied by an imbalance in the local oxygen supply. Under hypoxia, mitochondrial NADH and FADH cannot be oxidized by the mitochondrial electron transport chain, which leads to the accumulation of reducing equivalents and subsequent reduction stress. Detecting changes in intracellular NADH levels is expected to allow an assessment of stress.

Sox9CreER-mediated deletion of β-catenin in palatal mesenchyme results in delayed palatal elevation accompanied with repressed canonical Wnt signaling and reduced actin polymerization.

Cleft palate is a good model to pushing us toward a deeper understanding of the molecular mechanisms of spatiotemporal patterns in tissues and organisms because of the multiple-step processes such as elevation and fusion. Previous studies have shown that the epithelial β-catenin is crucial for palatal fusion, however, the function of the mesenchymal β-catenin remains elusive. We investigate the role of mesenchymal β-catenin in palatal development by generating a β-catenin conditional knockout mouse (CKO) (Sox9CreER; Ctnnb1 ).

A new congenital cleft palate New Zealand rabbit model for surgical research.

Cleft palate repair is a challenging procedure for cleft surgeons to teach, and in research, it can be difficult to evaluate different techniques and develop new treatments. In this study, a congenital cleft palate New Zealand rabbit model has been described and could be beneficial in future studies concerning cleft palate repair. Pregnant New Zealand rabbits received 1.

Assessment of available sites for palatal orthodontic mini-implants through cone-beam computed tomography.

Objective: To measure the palatal thickness of both hard and soft tissues and to determine safe regions for the placement of mini-implants. The influences of sex and age on palatal thickness were also examined.

Materials And Methods: Cone-beam computed tomography images of 30 patients (12 males, 18 females), including 15 adults and 15 adolescents, were used in this study.