Melatonin, a lipophilic hormone released from the pineal gland, has oncostatic effects on various types of cancers. However, its cancer treatment potential needs to be improved by deciphering its corresponding mechanisms of action and optimising therapeutic strategy. In the present study, melatonin inhibited gastric cancer cell migration and soft agar colony formation.
View Article and Find Full Text PDFB-cell receptor-associated protein 31 (BAP31) has been shown to overexpress in a wide range type of cancers. The present study aims to investigate the role of BAP31 on migration in lung cancer. Results showed that the migration of BAP31 knockdown cells was weaken than the control cells.
View Article and Find Full Text PDFThe phytoalexin resveratrol exhibits anti-tumour activity in many types of cancer. In this study, we showed that resveratrol suppressed the survival of gastric tumour cells both in vivo and in vitro. Resveratrol promoted apoptosis, autophagy and endoplasmic reticulum (ER) stress in a dose-dependent manner.
View Article and Find Full Text PDFMagnesium, an essential mineral micronutrient, plays a role in the activation of various transporters and enzymes. The present study aimed to investigate the possibility of applying magnesium to enhance the efficacy of cisplatin which is still ranked as one of the major chemotherapeutic drugs for bladder cancer patients. Results showed that the survival rate and colony formation of bladder cancer cells were reduced by combinatorial treatment with cisplatin and magnesium chloride (MgCl).
View Article and Find Full Text PDFMalevolent creativity, as one dark side of creativity, refers to manifestations people propose to harm themselves or others materially, mentally, or physically in an innovative way. This study aimed to explore the neural correlates of malevolent creative idea generation using task-based static and dynamic functional connectivity (FC) analysis across different time periods. We collected 34 participants who performed malevolent creativity task (MCT), benevolent creativity task (BCT), and realistic presented problems task (RPPT) in the fMRI scanner.
View Article and Find Full Text PDFJ Air Waste Manag Assoc
September 2007
China's national government and Beijing city authorities have adopted additional control measures to reduce the negative impact of vehicle emissions on Beijing's air quality. An evaluation of the effectiveness of these measures may provide guidance for future vehicle emission control strategy development. In-use emissions from light-duty gasoline vehicles (LDGVs) were investigated at five sites in Beijing with remote sensing instrumentation.
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