Three-dimensional macroscopic graphene supported vertically-ordered mesoporous silica-nanochannel film for direct and ultrasensitive detection of uric acid in serum.

Direct, rapid and sensitive detection of physiologically-relevant active small molecules (ASMs) in complex biological samples is highly desirable. Herein, we present an electrochemical sensing platform by combining three-dimensional macroscopic graphene (3DG) and vertically-ordered mesoporous silica-nanochannel film (VMSF), which is able to directly detect ASMs in complex samples with high sensitivity and no need of tedious pretreatment. Free-standing and macroscopic 3DG serves as the supporting electrode and O-plasma treatment is proposed as a simple and green approach to improve its hydrophilicity and electrochemical activity.

Integration of vertically-ordered mesoporous silica-nanochannel film with electro-activated glassy carbon electrode for improved electroanalysis in complex samples.

Vertically-ordered mesoporous silica-nanochannel films (VMSF) with highly ordered nanochannels, uniform and adjustable pore size, ultra-thin thickness, and high porosity, have attracted considerable attention in analysis, molecular separation, catalysis, and nanomaterial synthesis. However, their widespread applications in practical electrochemical sensing are largely limited by the poor adhesion to common electrode materials, especially the lack of highly active substrate electrode to equip mechanically stable VMSF. Herein, we report a facile strategy to fabricate VMSF on widely used sensing electrodes without the use of any chemical adhesive for developing superior VMSF based electrochemical sensors.