Participation of Strong H-Bonding to Acidic Groups Contributes to the Intense Sorption of the Anionic Munition, Nitrotriazolone (NTO) to the Carbon, Filtrasorb 400.

5-Nitro-1,2-dihydro-3H-1,2,4-triazin-3-one ("nitrotriazolone," NTO) is an insensitive munition compound used in modern weaponry. It poses a potential threat to soil and water quality at relevant sites due to its physical properties that cause high mobility in the environment. NTO is polar and predominantly monoanionic (NTO) at environmental pH (p = 3.

Macroautophagy/autophagy promotes resistance to KRAS-targeted therapy through glutathione synthesis.

KRAS mutation-driven pancreatic ductal adenocarcinoma (PDAC) represents a major challenge in medicine due to late diagnosis and treatment resistance. Here, we report that macroautophagy (hereafter autophagy), a cellular degradation and recycling process, contributes to acquired resistance against novel KRAS-targeted therapy. The KRAS protein inhibitor MRTX1133 induces autophagy in KRAS-mutated PDAC cells by blocking MTOR activity, and increased autophagic flux prevents apoptosis.

Gamma-glutamyl transferase secreted by Helicobacter pylori promotes the development of gastric cancer by affecting the energy metabolism and histone methylation status of gastric epithelial cells.

Background: Helicobacter pylori (H. pylori) infection is critical in the development and occurrence of gastric cancer. H.

Ferroptotic therapy in cancer: benefits, side effects, and risks.

Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular content release. Originally investigated as a targeted therapy for cancer cells carrying oncogenic RAS mutations, ferroptosis induction now exhibits potential to complement chemotherapy, immunotherapy, and radiotherapy in various cancer types. However, it can lead to side effects, including immune cell death, bone marrow impairment, liver and kidney damage, cachexia (severe weight loss and muscle wasting), and secondary tumorigenesis.

Oridonin attenuated human PC-3 cell activity by modulating the Wnt/β-catenin signaling.

Background: Prostate cancer (PC) prevention is effectively achieved through its inhibition. Oridonin (ORD), an active diterpenoid isolated from Rabdosia rubescens, has been shown to have an inhibitory effect on PC cells, although its impact on PC is unknown.

Objectives: The present work investigated the actions and probable mechanisms of ORD on cellular proliferation, apoptosis, PC, and the wingless-type MMTV integration site family member 2 (Wnt)/β-catenin signaling pathway using the androgen-independent PC-3 cell line.

Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation.

The mechanism of nuclear size determination and alteration during normal lineage development and cancer pathologies which is not fully understood. As recently reported, chromatin modification can change nuclear morphology. Therefore, we screened a range of pharmacological chemical compounds that impact the activity of chromatin-modifying enzymes, in order to get a clue of the specific types of chromatin-modifying enzymes that remarkably effect nuclear size and shape.

Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2.

Background: Our previous study found that bone marrow-derived mesenchymal stem cells (BMSCs) promote Helicobacter pylori (H pylori)-associated gastric cancer (GC) progression by secreting thrombospondin-2 (THBS2). Extracellular vesicles (EVs) are important carriers for intercellular communication, and EVs secreted by BMSCs have been shown to be closely related to tumor development. The aim of this study was to investigate whether BMSC-derived microvesicles (MVs, a main type of EV) play a role in H.

Electrical Activity and Extremes of Individual Suspended ZnO Nanowires for 3D Nanoelectronic Applications.

We explored the electrical activity and extremes inside individual suspended zinc oxide (ZnO) nanowires (NWs) (diameter: 50-550 nm, length: 5-50 μm) subjected to high forward bias-induced Joule heating using two-terminal current-voltage measurements. NWs were isolated using a reproducible nanometrology technique, employing a nanomanipulator inside a scanning electron microscope. Schottky behavior is observed between installed tips and ZnO NW.

Significant correlation between glucose metabolism status and acute radiation enteritis resulting from concurrent chemoradiotherapy in rectal cancer.

Objective: To explore the relationship between glucose metabolism and acute radiation enteritis from chemoradiotherapy for rectal cancer.

Methods: In this retrospective study, the clinical data of 75 rectal cancer patients who received concurrent chemoradiotherapy in Binzhou Second People's Hospital from February 2019 to February 2022 were collected and analyzed. According to the Radiation Therapy Oncology Group (RTOG)/European Organization for Research on Treatment of Cancer (EORTC) radiation response grading criteria, the patients were classified into four groups with different glucose metabolism statuses: NGR (normal glucose regulation) group, IFG (impaired fasting glucose) group, IGT (impaired glucose tolerance) group, and DM (diabetes mellitus) group.

Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells.

Proper organization of intracellular assemblies is fundamental for efficient promotion of biochemical processes and optimal assembly functionality. Although advances in imaging technologies have shed light on how the centrosome is organized, how its constituent proteins are coherently architected to elicit downstream events remains poorly understood. Using multidisciplinary approaches, we showed that two long coiled-coil proteins, Cep63 and Cep152, form a heterotetrameric building block that undergoes a stepwise formation into higher molecular weight complexes, ultimately generating a cylindrical architecture around a centriole.

Z-scheme plasmonic Ag decorated BiWO/NiO hybrids for enhanced photocatalytic treatment of naphthenic acids in real oil sands process water under simulated solar irradiation.

A novel photocatalyst, BiWO/NiO/Ag, with hierarchical flower-like Z-scheme heterojunction, which exhibited excellent stability and photocatalytic activity over a wide light spectrum, was firstly synthesized and used in the remediation of real oil sands process water (OSPW) and achieved complete removal of aromatics, classical naphthenic acids (NAs), and heteroatomic NAs after 6 h of photocatalytic treatment. The acute toxicity of OSPW was completely eliminated after only 2 h of treatment. h and ∙OH were found to be the major oxidative species in the photocatalytic system.

Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation.

Cell lineage specification is accomplished by a concerted action of chromatin remodeling and tissue-specific transcription factors. However, the mechanisms that induce and maintain appropriate lineage-specific gene expression remain elusive. Here, we used an unbiased proteomics approach to characterize chromatin regulators that mediate the induction of neuronal cell fate.

Source identification and apportionment of the nitrogen in groundwater based on isotope methods in the Beilin region of Suihua basin, northeastern China.

Multi-isotope method was used to analyze the migration and transformation characteristics of nitrogen in groundwater in the center of a typical confined water basin, and a simplified isotope mixing model was established to quantify the contribution of potential nitrate sources in the center of the basin. Based on the water quality monitoring results, the contour map of nitrate concentration in groundwater in the center of the basin was drawn. The results showed that the nitrate concentration in groundwater in the center of the basin increased gradually from upstream to downstream.

Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice.

Background: The zinc finger domain containing transcription factor Myt1l is tightly associated with neuronal identity and is the only transcription factor known that is both neuron-specific and expressed in all neuronal subtypes. We identified Myt1l as a powerful reprogramming factor that, in combination with the proneural bHLH factor Ascl1, could induce neuronal fate in fibroblasts. Molecularly, we found it to repress many non-neuronal gene programs, explaining its supportive role to induce and safeguard neuronal identity in combination with proneural bHLH transcriptional activators.

Gamma-glutamyltransferase of Helicobacter pylori alters the proliferation, migration, and pluripotency of mesenchymal stem cells by affecting metabolism and methylation status.

Virulence factor gamma-glutamyltransferase (GGT) of H. pylori consumes glutamine (Gln) in the stomach to decrease the tricarboxylic acid metabolite alpha-ketoglutarate (α-kg) and alter the downstream regulation of α-kg as well as cellular biological characteristics. Our previous research indicated that under H.

Transient receptor potential channels in multiple myeloma.

Multiple myeloma is the second most commonly diagnosed hematologic malignancy. As an incurable disease, the molecular mechanisms underlying its many aspects remain unclear. Intracellular calcium ion is an essential signaling molecule that modulates malignant cell behavior, and abnormal regulation of cellular calcium homeostasis may promote cancer cell survival and induce drug resistance.

A Five-Parameter Logistic Model to Predict the Possibility of Misdiagnosis for Improving the Specificity of Lugol Chromoendoscopy in the Diagnosis of Esophageal Neoplastic Lesions.

Background: Lugol chromoendoscopy (LCE) is a technique that is inexpensive and convenient for screening esophageal neoplastic lesions. However, the specificity of LCE is limited. The purpose of this study was to determine the risk characteristics of lesions related to false-positive results for LCE.

Research on the dynamic hammering method for identifying weak parts in cantilever structures.

Identification of the vulnerabilities in the structural stiffness is one of the most crucial issues in improving this property of machine tools. In this paper, the Flexibility Matrix Diagonal element method, based on hammer testing, is proposed as an effective approach to identifying the stiffness weakness of cantilever structures. To verify the proposed method, the element stiffness weakening is used to simulate the weak parts regarding stiffness.

Bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by secreting thrombospondin-2.

Objectives: Bone marrow-derived cells (BMDCs), especially mesenchymal stem cells (MSCs), may be involved in the development of Helicobacter pylori-associated gastric cancer (GC) in mice, but the specific mechanism remains unclear, and evidence from human studies is lacking.

Materials And Methods: To verify the role of BM-MSCs in H pylori-associated GC, green fluorescent protein (GFP)-labelled BM-MSCs were transplanted into the subserosal layers of the stomach in a mouse model of chronic H pylori infection. Three months post-transplantation, the mice were sacrificed, and the gastric tissues were subjected to histopathological and immunofluorescence analyses.

The treatment of electroplating wastewater using an integrated approach of interior microelectrolysis and Fenton combined with recycle ferrite.

Heavy metal ions in chelated forms have aroused great concerns because of their high solubility, poor biodegradation and extreme stability. In this research, an efficient strategy, interior microelectrolysis-Fenton-recycle ferrite (IM-Fenton-RF), was developed to treat simulated electroplating wastewater containing chelated copper at room temperature. The decomplexation of chelated copper was carried out by both interior microelectrolysis and Fenton reactions.

Research on the dynamic identification method of weak parts in cantilever structures.

Determining the weak parts of a structure is one of the key issues in the field of machine tool stiffness improvement. However, studies show that overcoming the static deformation with acquisition difficulty is a complex problem in practical structures. This study considers the machine tool cantilever structure, as a cantilever beam and bar structure, where the objective is to propose a weakness index, to identify the weak part, using system reconstruction to extract the measured static deformation data and the fitting data.

Molecular Characterization, Gene Evolution and Expression Analysis of the F-Box Gene Family in Tomato ().

F-box genes play an important role in the growth and development of plants, but there are few studies on its role in a plant's response to abiotic stresses. In order to further study the functions of F-box genes in tomato (, ), a total of 139 F-box genes were identified in the whole genome of tomato using bioinformatics methods, and the basic information, transcript structure, conserved motif, cis-elements, chromosomal location, gene evolution, phylogenetic relationship, expression patterns and the expression under cold stress, drought stress, jasmonic acid (JA) treatment and salicylic acid (SA) treatment were analyzed. The results showed that genes were distributed on 12 chromosomes of tomato and were prone to TD (tandem duplication) at the ends of chromosomes.