Iron-Cobalt Alloy@Graphene-Engineered Milk Extracellular Vesicles for Gastric Retentive Drug Delivery.

Oral drug delivery is widely used for treating gastric diseases as it allows drugs to act directly on gastric lesions, thereby improving therapeutic outcomes. However, its efficacy is hindered by the specific gastric environment, such as the gastric mucosal barrier, which limits drug penetration, and the short gastric emptying time, which results in transient residence time. Raw milk-derived extracellular vesicles (M-EVs) offer promise as a gastric drug delivery platform.

Colorimetric and photothermal dual-mode lateral flow immunoassay based on Au-FeO multifunctional nanoparticles for detection of Salmonella typhimurium.

Au-FeO multifunctional nanoparticles (NPs) were synthesized and integrated with lateral flow immunoassay (LFIA) for dual-mode detection of Salmonella typhimurium. The Au-FeO NPs not only combined excellent local surface plasmon resonance characteristics and superparamagnetic properties, but also exhibited good photothermal effect. In the detection, antibody-conjugated Au-FeO NPs first captured S.