Hyperfunction of the dopamine system has been implicated in manic episodes in bipolar disorders. How dopaminergic neuronal function is regulated in the pathogenesis of mania remains unclear. Histaminergic neurons project dense efferents into the midbrain dopaminergic nuclei.
View Article and Find Full Text PDFWe present multiPrime, a novel tool that automatically designs minimal primer sets for targeted next-generation sequencing, tailored to specific microbiomes or genes. MultiPrime enhances primer coverage by designing primers with mismatch tolerance and ensures both high compatibility and specificity. We evaluated the performance of multiPrime using a data set of 43,016 sequences from eight viruses.
View Article and Find Full Text PDFInternational students studying and living in a foreign context often complain about difficulties establishing friendships with host nationals. This study investigates host country nationals' (HCNs) willingness to develop intercultural friendships with international students who are sojourning in China by exploring the effects of face-to-face and online intergroup contact, HCNs' attitudes, intercultural communication competence (ICC), and perceived intergroup threats. Survey data from 469 HCNs indicate that (a) face-to-face and online contact are indirectly and positively related to their willingness to form intercultural friendships, (b) face-to-face contact can moderate the relationships of online contact with HCNs' intergroup attitudes and perceived intergroup threats, and (c) both ICC and intergroup attitudes can positively predict friendship formation whereas perceived intergroup threats act as a negative predictor.
View Article and Find Full Text PDFBackground: A growing body of literature demonstrates that social media usage has witnessed a rapid increase in higher education and is almost ubiquitous among young people. The underlying mechanisms as to how social media usage by university students affects their well-being are unclear. Moreover, current research has produced conflicting evidence concerning the potential effects of social media on individuals' overall well-being with some reporting negative outcomes while others revealing beneficial results.
View Article and Find Full Text PDFDrugs that target the human serotonin 2A receptor (5-HTR) are used to treat neuropsychiatric diseases; however, many have hallucinogenic effects, hampering their use. Here, we present structures of 5-HTR complexed with the psychedelic drugs psilocin (the active metabolite of psilocybin) and d-lysergic acid diethylamide (LSD), as well as the endogenous neurotransmitter serotonin and the nonhallucinogenic psychedelic analog lisuride. Serotonin and psilocin display a second binding mode in addition to the canonical mode, which enabled the design of the psychedelic IHCH-7113 (a substructure of antipsychotic lumateperone) and several 5-HTR β-arrestin-biased agonists that displayed antidepressant-like activity in mice but without hallucinogenic effects.
View Article and Find Full Text PDFSyst Appl Microbiol
September 2021
Rpf protein, a kind of resuscitation promoting factor, was first found in the culture supernatant of Micrococcus luteus. It can resuscitate the growth of M. luteus in "viable but non-culture, VBNC" state and promote the growth of Gram-positive bacteria with high G + C content.
View Article and Find Full Text PDFA bioassay-guided fractionation led to the isolation of hangtaimycin (HTM) from Streptomyces spectabilis CCTCC M2017417 and the discovery of its hepatoprotective properties. Structure elucidation by NMR suggested the need for a structural revision. A putative HTM degradation product was also isolated and its structure was confirmed by total synthesis.
View Article and Find Full Text PDFTwo new ansamycin derivatives, damavaricin H () and protostreptovaricin VI () were isolated from the CCTCC M2017417 derived mutants of ΔstvP5 and ΔstvA2, respectively. The structures of and were established by analysis of the HRESIMS as well as 1D and 2D NMR datasets. The minimum inhibitory concentration (MIC) results showed that compounds and possessed the corresponding anti-MRSA bioactivities of 4 ∼ 8 μg/ml and 8 ∼ 16 μg/ml, which confirmed the structure-activity relationships of streptovaricins reported previously and also revealed that addition of the hydroxyl group at C-8 increased the anti-MRSA activity.
View Article and Find Full Text PDFTwo new spirotetronate natural products, lobophorin L () and lobophorin M (), together with three known lobophorin-like spirotetronate antibiotics (-) and two known ansamycins (-), were isolated from the marine-derived sp. 4506. The structures of and were established on the basis of HRESIMS as well as 1D and 2D NMR datasets.
View Article and Find Full Text PDFSHANK‑associated RH domain‑interacting protein (SHARPIN) is a component of the linear ubiquitin chain assembly complex that can enhance the NF‑κB and JNK signaling pathways, acting as a tumor‑associated protein in a variety of cancer types. The present study investigated the role of SHARPIN in cutaneous basal cell carcinoma (BCC). Human BCC (n=26) and normal skin (n=5) tissues, and BCC (TE354.
View Article and Find Full Text PDFInt J Syst Evol Microbiol
March 2019
A Gram-stain-negative, rod-shaped (0.2-0.4 µm×1.
View Article and Find Full Text PDFSHARPIN is an important component of the linear ubiquitin chain assembly complex (LUBAC). Loss of function of SHARPIN results in eosinophilic inflammation in multiple organs including skin with Th -dominant cytokines and dysregulated development of lymphoid tissues in mice. The clinicopathological features are similar to atopic dermatitis (AD) in humans.
View Article and Find Full Text PDF© LitMetric 2025. All rights reserved.