N'-(2'-Deoxyguanosin-8-yl)-4-aminobiphenyl (dG) is one of the most representative carcinogenic DNA adducts formed by human exposure to 4-aminobiphenyl (4-ABP) during dye production, rubber-manufacturing processes and cigarette smoke. Accordingly, the ultrasensitive detection of ABP-derived adducts in DNA with minimal interference to the native structures becomes key for elucidating carcinogenesis mechanisms and mitigating the risk of cancer. In view of the lack of efficient optical emission in G, we report a theoretical study on the photophysical properties of a set of quasi-intrinsic fluorescent C-analogues, which can form stable W-C base pairs with G.
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December 2022
The 8-oxo-7,8-dihydro-2'-deoxyguanine (8-oxoG) is the representative damaged nucleoside that may increase the risk of developing diseases. Accordingly, the selective detection of 8-oxoG in DNA with minimal disturbance to the native structure is important to have an in-depth understanding of the formation mechanism and becomes an attractive tool for genomic research. To identify the DNA adduct in real-time efficiently, a series of quasi-intrinsic optical probes are performed based on the natural adenine, which has preference to form a stable base pair with 8-oxoG in the syn conformation.
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February 2023
Energy storage systems (ESSs)-based demand response (DR) is an appealing way to save electricity bills for consumers under demand charge and time-of-use (TOU) price. In order to counteract the high investment cost of ESS, a novel operator-enabled ESS sharing scheme, namely, the "operator-as-a-consumer (OaaC)," is proposed and investigated in this article. In this scheme, the users and the operator form a Stackelberg game.
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