Publications by authors named "Lingjia Hong"
Article Synopsis
- Tumor-associated macrophages (TAMs) play a significant role in cancer progression but their differentiation process is not well understood, particularly in triple-negative breast cancer (TNBC).
- The study identified that inhibiting heat shock protein 90 (HSP90) blocked the differentiation of monocytes into TAMs in TNBC, and TNBC-derived signals activated pathways that promote this differentiation.
- HSP90 was found to be secreted by TNBC, promoting TAM differentiation, and using an HSP90 inhibitor in mouse models reduced tumor growth and TAM levels, highlighting HSP90 as a potential target for improving immunotherapy in TNBC.
