Low-dose adropin stimulates inflammasome activation of macrophage via mitochondrial ROS involved in colorectal cancer progression.

Adropin is encoded by the energy homeostasis-associated (ENHO) gene and widely present in liver, pancreas, heart, kidney, brain, and vascular tissues. Abnormal adropin is associated with metabolic, inflammatory, immune, and central nervous disorders. Whether adropin is involved in the development of colorectal cancer (CRC) is still unclear.

15-Methacryloyloxypentadecyl Dihydrogen Phosphate Improves Resin-to-Zirconia Bonding Durability.

Purpose: To investigate the bond durability of composite cement to zirconia after treatment with a 15-methacryloyloxypentadecyl dihydrogen phosphate (15-MPDP)-containing adhesive and 2 commercially available adhesives.

Materials And Methods: Ninety zirconia bars were fabricated and bonded to prepolymerized resin composite cylinders with a composite cement after surface treatment for 20 s using the following adhesives: Adper Easy One (AEO, negative control), Single Bond Universal (SBU, positive control), and 10 wt% 15-MPDP powder mixed with Adper Easy One (15- MPDP). After storage in distilled water at 37°C for 24 h, the specimens were divided into 3 subgroups according to the aging treatment applied (n = 10): no aging treatment (0/TC), 10,000 thermocycles (1/TC), and 37,500 thermocycles (3/TC).

MicroRNA-28-5p as a potential diagnostic biomarker for chronic periodontitis and its role in cell proliferation and inflammatory response.

Background/purpose: Recent studies have pointed to the crucial role of microRNAs (miRNAs) in chronic periodontitis (CP). This study investigated the regulation and potential mechanisms of miR-28-5p in CP patients and lipopolysaccharide (LPS)-induced periodontal ligament cells (PDLCs).

Materials And Methods: 76 CP patients and 71 periodontally healthy subjects were included.

CircPUM1 Knockdown Confers Radiosensitivity in Oral Squamous Cell Carcinoma by Regulating the miR-580/STAT3 Pathway.

CircPUM1 acts as an oncogene in a variety of tumors, and there is no related research on oral squamous cell carcinoma. This study aimed to evaluate the clinical significance of CircPUM1 in oral squamous cell carcinoma radiotherapy. Radio-resistant cell lines were established by increasing the X-ray dose.

Dual-wavelength distributed feedback fiber laser based on double exposure and equivalent phase shift method.

A special sampling structure based on double exposure technology is proposed to achieve dual-wavelength lasing in the distributed feedback fiber laser. This structure is composed of two grating pitches in one sampling period, which could be realized by changing the fiber's length in the fabrication. Through employing an equivalent phase shift, only a submicrometer-level precision is required for precise phase control.