Publications by authors named "Linghua Ding"
Study on the influence of scaffold morphology and structure on osteogenic performance.
Front Bioeng Biotechnol
March 2023
Article Synopsis
- * Current treatments often use cytokines for promoting fracture healing, but they can trigger immune responses and are costly, resulting in less effective clinical outcomes.
- * New research is focusing on tissue-induced biomaterials that promote bone regeneration through optimized scaffold structures, potentially improving tissue-engineered bones without the need for expensive cytokine additions.
Article Synopsis
- Autogenous and allogenic bone transplantation are common methods for treating bone issues, but they have limitations that affect their widespread use in medicine.
- This study tests PLGA microspheres carrying pOsterix/PEI nanoparticles to see if they can effectively repair bone defects and investigates how they work.
- Results show that PLGA@pOsx/PEI is safe, boosts important proteins for bone formation, and promotes bone healing in models, suggesting it could be a useful material for clinical bone repair.
Article Synopsis
- - The study explores the role of the BMP-2-TAK1-p38-Osx signaling pathway in bone repair using a composite of hollow hydroxyapatite (HA) microspheres and chitosan (CS).
- - Researchers tested the biological activity of rhBMP-2, conducted osteoblast differentiation tests, and assessed gene expression involved in bone formation.
- - Results indicate that the BMP-2-TAK1-p38-Osx pathway is crucial for bone repair, with significant differences observed in groups treated with TAK1 and p38 inhibitors, highlighting the effectiveness of the composite material in promoting bone growth.
Article Synopsis
- The study investigated how a composite made of hollow hydroxyapatite microspheres and chitosan can deliver recombinant proteins rhBMP-2 and rhCXCL13 for bone repair.
- Findings showed that rhBMP-2 enhances the proliferation and differentiation of bone marrow stem cells, while rhCXCL13 promotes their migration, leading to improved bone healing.
- The research suggests that this composite could be a promising method for bone regeneration by effectively delivering these proteins to enhance the body's repair mechanisms.
Improving the thermal and chemical stabilities of classical polymer membranes will be beneficial to extend their applications in the high temperature or aggressive environment. In this work, the asymmetric ultrafiltration membranes prepared from the polyacrylonitrile (PAN) were used to fabricate the cross-linking asymmetric (CLA) PAN membranes via thermal cross-linking in air to improve their thermal and chemical stabilities. The effects of thermal cross-linking parameters such as temperature and holding time on the structure, gas separation performance, thermal and chemical stabilities of PAN membranes were investigated by Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), positron annihilation lifetime spectroscopy (PALS), scanning electron microscopy (SEM), thermogravimetic analysis (TGA) and gas permeation test.
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- - This study evaluated the effects of a hydroxyapatite bone repair scaffold coated with bone morphogenetic protein-2 on murine calvarial defect models, reviewing the quality of these studies based on specific reporting guidelines.
- - Out of 12 eligible studies, most had average quality scores, with key deficiencies in reporting aspects like housing, allocation, and generalizability.
- - The use of bone morphogenetic protein-2 significantly improved bone regeneration and blood vessel formation in these models, but the results indicated a lack of uniformity across the studies, emphasizing the need for adherence to reporting guidelines for better research integrity.
Scaffolds for the repair of bone defects in clinical studies: a systematic review.
J Orthop Surg Res
February 2018
Article Synopsis
- - This systematic review focuses on summarizing clinical studies concerning scaffolds used in repairing bony defects.
- - A thorough search on PubMed yielded 373 articles, but only 20 met the criteria for inclusion, covering both biological (like collagen) and synthetic scaffolds (such as HAp and TCP) in their analysis.
- - While the review found that scaffolds can effectively aid bone repair and regeneration, it highlighted the need for better guidelines and higher-quality research in this area.