Fabrication of porcine acellular dermal matrix and oxidized hyaluronic acid conductive composite hydrogels for accelerating skin wound healing under electrical stimulation.

Electrical stimulation (ES) of skin wounds can promote cell proliferation, protein synthesis, inflammatory response, and improve neurological function. In this study, the dynamical cross-linked conductive hydrogels have been developed by integration of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) into porcine acellular dermal matrix (PADM) and oxidized hyaluronic acid (OHA) using dopamine-Fe complex (DA@Fe) as cross-linking agent. The as-obtained conductive composite hydrogels have the characteristics of rapid gelation, excellent deformation ability, high water absorption, and suitable degradation rate.

Silk fibroin and hydroxypropyl cellulose composite injectable hydrogel-containing extracellular vesicles for myocardial infarction repair.

Extracellular vesicles (EVs) have been recognized as one of the promising specific drugs for myocardial infarction (MI) prognosis. Nevertheless, low intramyocardial retention of EVs remains a major impediment to their clinical application. In this study, we developed a silk fibroin/hydroxypropyl cellulose (SF/HPC) composite hydrogel combined with AC16 cell-derived EVs targeted modification by folic acid for the treatment of acute myocardial infarction repair.

Network pharmacology-based approach to explore the underlying mechanism of sinomenine on sepsis-induced myocardial injury in rats.

Sepsis, a systemic disease, usually induces myocardial injury (MI), and sepsis-induced MI has become a significant contributor to sepsis-related deaths in the intensive care unit. The objective of this study is to investigate the role of sinomenine (SIN) on sepsis-induced MI and clarify the underlying mechanism based on the techniques of network pharmacology. Cecum ligation and puncture (CLP) was adopted to induce sepsis in male Sprague-Dawley (SD) rats.

Synthesis and characterization of three-dimensional crosslinked networks based on self-assemly of α-cyclodextrins with thiolated 4-arm PEG using a three-step oxidation.

A kind of novel three-dimensional crosslinked networks based on the self-assemly of α-CDs with thiolated four-arm PEG was prepared by thiol-disulfide interchange reaction using a three-step oxidation. The supramolecular structure of the resulting hydrogels was characterized FTIR, H NMR, XRD, DSC and TGA measurements. The results demonstrated that the channel-type crystalline structure of inclusion complexes is still maintained after the multi-step oxidation.