Distraction or motivation? Unraveling the role of fear of missing out on college students' learning engagement.

Background: Despite the recognition of the impact of Fear of Missing Out (FoMO) on learning engagement, research conclusions remain inconsistent. This inconsistency may be due to a lack of exploration of the underlying mechanisms and the singularity of research perspectives.

Methods: Drawing from motivational dynamics model for learning engagement, this study investigated the relationship between FoMO and learning engagement from both variable-centered and person-centered perspectives, and further explored the mediating role of self-control.

Integrated "all-in-one" strategy to construct highly efficient Pd catalyst for CO transformation.

The synthesis of high-value chemicals featuring C-C and/or C-heteroatom bonds CO is critically important, yet efficiently converting thermodynamically stable and kinetically inert linear CO and propargylic amine to the heterocyclic compound 2-oxazolidinone with an integrated catalytic system continues to pose a considerable challenge. Herein, we have designed an "all-in-one" (AIO) palladium (Pd) catalyst (Cat1), distinguished by its co-coordination with acetylglucose (AcGlu) and bis(benzimidazolium) units at the Pd center, which promotes the cyclization of CO and propargylic amine achieving a highest turnover frequency (TOF) of up to 3456 h. Moreover, Cat1 demonstrates excellent stability across various temperatures, with its catalytic activity remaining unchanged even after 10 cycles.

miR-506 in patients with chronic myeloid leukemia and its effect on apoptosis of K562 cells.

Objective: To explore the expression of miR-506 in chronic myeloid leukemia (CML) and its influence on the biological function of CML cells.

Methods: Altogether 84 CML patients from February 2012 to September 2014 were obtained as the observation group (OG), and 71 healthy people were taken as the control group (CG). miR-506 was tested using RT-qPCR, and the 5-year survival of patients with high and low expression of miR-506 was compared with the median value of miR-506 as the limit.

miR-497-5p induces apoptosis in K562 cells by downregulating ROCK1.

Objective: To validate the role of miR-497-5p in apoptosis in K562 cells by targeting Rho-associated kinase isoform 1 (ROCK1).

Methods: From January, 2017 to February, 2019, 57 patients with chronic myeloid leukemia (CML) treated in our hospital were included in patient group, and 50 healthy individuals were recruited as control group. miR-497-5p level in peripheral blood was quantitated using qRT-PCR.

Broad bean wilt virus 2 encoded VP53, VP37 and large capsid protein orchestrate suppression of RNA silencing in plant.

Viruses encode RNA silencing suppressors to counteract host RNA silencing-mediated defense responses. In this study, we demonstrate that VP53, VP37 and LCP encoded by RNA2 of broad bean wilt virus 2 (BBWV-2), a member of the genus Fabavirus, are strong suppressors of RNA silencing triggered by single-stranded sense RNA. They, however, had no effect on suppression of RNA silencing induced by double-stranded RNA.

Interaction between Rice stripe virus disease-specific protein and host PsbP enhances virus symptoms.

Rice stripe virus (RSV) causes severe diseases in Oryza sativa (rice) in many Eastern Asian countries. Disease-specific protein (SP) of RSV is a non-structural protein and its accumulation level in rice plant was shown to determine the severity of RSV symptoms. Here, we present evidence that expression of RSV SP alone in rice or Nicotiana benthamiana did not produce visible symptoms.

Cerium oxide nanoparticles induce cytotoxicity in human hepatoma SMMC-7721 cells via oxidative stress and the activation of MAPK signaling pathways.

Background: Lanthanide cerium oxide (CeO2) nanoparticles have extensive applications in industrial fields, and concerns regarding their potential toxicity in humans and their environmental impact have increased. We investigated the underlying molecular mechanisms by which CeO2 nanoparticles induce toxicity in human hepatoma SMMC-7721 cells.

Results: Our results demonstrated that CeO2 nanoparticles reduced viability, caused dramatic morphological damage, and induced apoptosis in SMMC-7721 cells.

Binary optical encoding strategy for multiplex assay.

A binary optical encoding strategy is proposed to meet the increasing requirements of multiplex bioassays. As illustrated in fluorescence immunodetection of multiplex antigen molecules, photonic crystal beads (PCBs) and quantum dots (QDs) can be used as biomolecular microcarriers and fluorescence labels, respectively. The categories of antigens were deciphered by the binary combination of optical spectra of PCBs and QDs as independent encoding elements.

Study on the relationship between G1057D variants of IRS2 gene and obese T2DM in Chinese Han subjects.

Objective: To investigate the relationship between the G1057D variants of insulin receptor substrate-2(IRS2) gene and type 2 diabetes mellitus (T2DM) in subjects.

Methods: Four hundred and thirty-nine Chinese Han subjects, including 218 patients with T2DM and 221 normal controls, were selected from the Hans in the Liaoning area, and each group was divided into two subgroups according to body mass index. The G1057D variants of IRS2 were detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) and their relationships with T2DM were analyzed.