Benefits of heat-killed on growth performance, nutrient digestibility, antioxidant status, immunity, and cecal microbiota of rabbits.

Introduction: Heat-killed probiotics, as a type of inactivated beneficial microorganisms, possess an extended shelf life and broader adaptability compared to their live counterparts. This study aimed to investigate the impact of heat-killed (, LA) - a deactivated probiotic on the growth performance, digestibility, antioxidant status, immunity and cecal microbiota of rabbits.

Methods: Two hundred weaned Hyla rabbits were randomly allocated into five equal groups (CON, L, L, L, and L).

Highly Reversible Chevrel Phase MoSe Cathode with Low Voltage Hysteresis for Rechargeable Aluminum Batteries.

Rechargeable aluminum (Al) batteries have attracted considerable interest as potential large-scale energy storage technologies due to the abundance, high theoretical capacity, and high safety of Al. We report here a highly reversible Al-MoSe prototype cell with low discharge-charge hysteresis (approximately 50 mV under 30 mA g at 50 °C), ultra-flat discharge plateau, and exceptional cycle stability: the reversible capacity retaining at a steady 77 mA h g after more than 1800 cycles. The Al intercalation-extraction mechanism is probed with and XRD techniques, revealing the reversible intercalation reaction from MoSe to AlMoSe.

E2F2 drives glioma progression via PI3K/AKT in a PFKFB4-dependent manner.

Aims: The effects of PFKFB4 on glycolysis during the cancer progression has been investigated, while its role in glioma remains unclear. The present study evaluated the molecular mechanism of PFKFB4 in glycolysis of glioma progression.

Materials And Methods: The pan-cancer platform SangerBox was inquired to investigate the E2F2 expression in tumors.

Epigenetic targeting of SLC30A3 by HDAC1 is related to the malignant phenotype of glioblastoma.

The epigenetic abnormality is believed as a major driver for cancer initiation. Histone modification plays a vital role in tumor formation and progression. Particularly, alteration in histone acetylation has been highly associated with gene expression, cell cycle, as well as carcinogenesis.

Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications.

The imbalance of intestinal microecology firstly impairs intestinal mucosa barrier and function, then further damages the functions and homeostasis of distal organs, leading to systemic diseases. Nutrients, transplantation of bacteria flora and modes of life can shape gut microbiota and intestinal mucosa barrier and mitigate stress. Current researches demonstrate that dynamic epigenetic modifications of intestinal tissue strongly mediate the crosstalk between gut microbes and gut mucosa barrier.

Determination of -Carbamylglutamate in Feeds and Animal Products by High Performance Liquid Chromatography Tandem Mass Spectrometry.

-carbamylglutamate (NCG), a synthetic analogue of -acetylglutamate, is an activator of blood ammonia conversion and endogenous arginine synthesis. Here, we established an accurate quantitative determination of NCG in feeds, animal tissues, and body fluids using the high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). The sample pretreatment procedures included extraction with 0.