S-adenosyl-L-methionine supplementation alleviates aortic dissection by decreasing inflammatory infiltration.

Methionine, an indispensable amino acid crucial for dietary balance, intricately governs metabolic pathways. Disruption in its equilibrium has the potential to heighten homocysteine levels in both plasma and tissues, posing a conceivable risk of inducing inflammation and detriment to the integrity of vascular endothelial cells. The intricate interplay between methionine metabolism, with a specific focus on S-adenosyl-L-methionine (SAM), and the onset of thoracic aortic dissection (TAD) remains enigmatic despite acknowledging the pivotal role of inflammation in this vascular condition.

Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape.

How disruptions to normal cell differentiation link to tumorigenesis remains incompletely understood. Wilms tumor, an embryonal tumor associated with disrupted organogenesis, often harbors mutations in epigenetic regulators, but their role in kidney development remains unexplored. Here, we show at single-cell resolution that a Wilms tumor-associated mutation in the histone acetylation reader ENL disrupts kidney differentiation in mice by rewiring the gene regulatory landscape.

Single-Cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape.

Cell differentiation during organogenesis relies on precise epigenetic and transcriptional control. Disruptions to this regulation can result in developmental abnormalities and malignancies, yet the underlying mechanisms are not well understood. Wilms tumors, a type of embryonal tumor closely linked to disrupted organogenesis, harbor mutations in epigenetic regulators in 30-50% of cases.

Coexistence of Dirac points and nodal chains in photonic metacrystal.

Gapless topological phases, i.e. topological semimetals, come in various forms such as Weyl/Dirac semimetals, nodal line/chain semimetals, and surface-node semimetals.

Scalar topological photonic nested meta-crystals and skyrmion surface states in the light cone continuum.

Topological photonics is rapidly expanding. However, discovering three-dimensional topological electromagnetic systems can be more challenging than electronic systems for two reasons. First, the vectorial nature of electromagnetic waves results in complicated band dispersions, and simple tight-binding-type predictions usually fail.

Dirac-Weyl semimetal in photonic metacrystals.

Dirac-Weyl semimetal is a novel type of topological phase that features the coexistence of Dirac and Weyl points in momentum space. In this study, a photonic Dirac-Weyl semimetal is proposed by introducing screw rotation symmetries into a spatial inversion symmetry-lacking system. A realistic metacrystal structure is designed for experimental consideration.

Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer.

Growing evidence suggests prevalence of transcriptional condensates on chromatin, yet their mechanisms of formation and functional significance remain largely unclear. In human cancer, a series of mutations in the histone acetylation reader ENL create gain-of-function mutants with increased transcriptional activation ability. Here, we show that these mutations, clustered in ENL's structured acetyl-reading YEATS domain, trigger aberrant condensates at native genomic targets through multivalent homotypic and heterotypic interactions.

Malignancies in people living with HIV.

Almost 40 years have passed since the first case of what is known as AIDS was documented. In these 40 years, AIDS has always been a research challenge and hot spot. Researchers and scientists have made tremendous progress in basic and clinical research on HIV.

Tumor Microenvironment Profiles Reveal Distinct Therapy-Oriented Proteogenomic Characteristics in Colorectal Cancer.

Advances in immunotherapy have made an unprecedented leap in treating colorectal cancer (CRC). However, more effective therapeutic regimes need a deeper understanding of molecular architectures for precise patient stratification and therapeutic improvement. We profiled patients receiving neoadjuvant chemotherapy alone or in combination with immunotherapy (PD-1 checkpoint inhibitor) using Digital Spatial Profiler (DSP), a high-plex spatial proteogenomic technology.

Intrinsic in-plane nodal chain and generalized quaternion charge protected nodal link in photonics.

Nodal lines are degeneracies formed by crossing bands in three-dimensional momentum space. Interestingly, these degenerate lines can chain together via touching points and manifest as nodal chains. These nodal chains are usually embedded in two orthogonal planes and protected by the corresponding mirror symmetries.

Cellular and Immune Therapy for Treating HIV-1 Infection.

HIV-1 infection has caused a number of deaths worldwide and remains a global health concern. Combined antiretroviral therapy (cART) inhibits viral replication, prevents CD4+ T cell loss, and thus slows HIV disease progression. However, cART does not eradicate HIV-1.

Observation of Non-Abelian Nodal Links in Photonics.

In crystals, two bands may cross each other and form degeneracies along a closed loop in the three-dimensional momentum space, which is called nodal line. Nodal line degeneracy can be designed to exhibit various configurations such as nodal rings, chains, links, and knots. Very recently, non-Abelian band topology was proposed in nodal link systems, where the nodal lines formed by consecutive pairs of bands exhibit interesting braiding structures and the underlying topological charges are described by quaternions.

Spontaneous Emission and Resonant Scattering in Transition from Type I to Type II Photonic Weyl Systems.

Spontaneous emission and scattering behavior of an emitter or a resonant scatterer strongly depend on the density of states of the surrounding medium. It has been shown that the resonant scattering cross section (RSC) may diverge at the Weyl frequency of a type I Weyl system due to the diminishing density of states. Here we study the spontaneous emission (SE) and RSC in a photonic metacrystal across the critical transition between type I and type II Weyl systems.

Observation of Hourglass Nodal Lines in Photonics.

Nodal line semimetals exhibiting line degeneracies in three-dimensional momentum space have been demonstrated recently. In general, the presence of nodal line semimetals is protected by special symmetries, such as mirror symmetry. However, these symmetries are usually necessary but not sufficient conditions, as nodal lines can be annihilated even without breaking them.

Experimental observation of photonic nodal line degeneracies in metacrystals.

Nodal line semimetals (NLS) are three-dimensional (3D) crystals that support band crossings in the form of one-dimensional rings in the Brillouin zone. In the presence of spin-orbit coupling or lowered crystal symmetry, NLS may transform into Dirac semimetals, Weyl semimetals, or 3D topological insulators. In the photonics context, despite the realization of topological phases, such as Chern insulators, topological insulators, Weyl, and Dirac degeneracies, no experimental demonstration of photonic nodal lines (NLs) has been reported so far.

Three Dimensional Photonic Dirac Points in Metamaterials.

Topological semimetals, representing a new topological phase that lacks a full band gap in bulk states and exhibiting nontrivial topological orders, recently have been extended to photonic systems, predominantly in photonic crystals and to a lesser extent metamaterials. Photonic crystal realizations of Dirac degeneracies are protected by various space symmetries, where Bloch modes span the spin and orbital subspaces. Here, we theoretically show that Dirac points can also be realized in effective media through the intrinsic degrees of freedom in electromagnetism under electromagnetic duality.