Publications by authors named "Lingbin Du"

Background: Liver cancer continues to pose a significant burden in China. To enhance the efficiency of screening, it is crucial to implement population stratification for liver cancer surveillance.

Objective: This study aimed to develop a simple prediction model and risk score for liver cancer screening in the general population, with the goal of improving early detection and survival.

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Background: Esophageal cancer (EC) remains a global health challenge due to its poor prognosis. China and the United States of America (USA) represent two distinct epicenters of EC burden. Understanding the EC disparities in these two countries is vital for tailoring prevention strategies, optimizing treatment, and enhancing outcomes in both countries.

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Background: The fecal immunochemical test (FIT) has been widely used in colorectal cancer (CRC) screening, yet the practical performance of FIT combined with questionnaire-based risk assessment (QRA) remains undetermined. Moreover, risk factors for distinct CRC precursors identified in screening have been rarely compared.

Methods: This study was based on a population-based CRC screening in China, with 2,120,340 participants completing both FIT and QRA.

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Article Synopsis
  • Previous studies indicate endoscopic screening is effective in rural areas, but there's a lack of long-term evidence for risk-adapted upper gastrointestinal cancer (UGC) screening strategies in wealthier regions.
  • The study aimed to validate these risk-adapted screening strategies to prevent UGC and reduce mortality, involving a large cohort from four Chinese cities over several years.
  • Results showed that among high-risk participants offered screening, those who complied had significantly lower UGC-related and overall mortality rates compared to those who did not undergo screening.
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Family history (FH) of cancer and polygenic risk scores (PRS) are pivotal for cancer risk assessment, yet their combined impact remains unclear. Participants in the UK Biobank (UKB) were recruited between 2006 and 2010, with complete follow-up data updated until February 2020 for Scotland and January 2021 for England and Wales. Using UKB data (N = 442,399), we constructed PRS and incidence-weighted overall cancer PRS (CPRS).

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Changes in plasma and fecal metabolomes in colorectal cancer (CRC) progression (normal-adenoma-CRC) remain unclear. Here, plasma and fecal samples were collected from four independent cohorts of 1,251 individuals (422 CRC, 399 colorectal adenoma [CRA], and 430 normal controls [NC]). By metabolomic profiling, signature plasma and fecal metabolites with consistent shift across NC, CRA, and CRC are identified, including CRC-enriched oleic acid and CRC-depleted allocholic acid.

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Objective: This is a comprehensive overview of long-term cancer survival in Zhejiang Province, China. Hybrid analysis, a combination of cohort and period analysis, has been proposed to derive up-to-date cancer survival estimates. Using this approach, we aimed to timely and accurately analyze the 5-year relative survival (RS) and net survival (NS) in cancer registries of Zhejiang Province, China.

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Background: As the global population ages, the burden of cancer is increasing. We aimed to assess the impact of population ageing on cancer-related disability-adjusted life years (DALYs).

Methods: We used the decomposition method to estimate the impact of ageing, population growth, and epidemiological change on cancer-related DALYs from 1990 to 2019, stratified by 204 countries/territories and by their sociodemographic index (SDI).

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Risk prediction tools for colorectal cancer (CRC) have potential to improve the efficiency of population-based screening by facilitating risk-adapted strategies. However, such an applicable tool has yet to be established in the Chinese population. In this study, a risk score was created using data from the China Kadoorie Biobank (CKB), a nationwide cohort study of 409,854 eligible participants.

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Background: The incidence of early-onset colorectal cancer (EOCRC, diagnosed in patients under the age of 50 years) has been increasing around the world. Here, we aimed to systematically identify distinctive features of EOCRC.

Methods: From 2020 to 2021, we conducted a nationwide survey in 19 hospitals, collecting data on advanced CRC patients' demographics, clinical features, disease knowledge, medical experiences, expenditures, and health-related quality of life (HRQOL).

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Background: Screening reduces colorectal cancer (CRC) burden by allowing early resection of precancerous and cancerous lesions. An adequate selection of high-risk individuals and a high uptake rate for colonoscopy screening are critical to identifying people more likely to benefit from screening and allocating healthcare resources properly. We evaluated whether combining a questionnaire-based interview for risk factors with fecal immunochemical test (FIT) outcomes for high-risk assessment is more efficient and economical than a questionnaire-based interview-only strategy.

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Introduction: Several studies have proved that Polygenic Risk Score (PRS) is a potential candidate for realizing precision screening. The effectiveness of low-dose computed tomography (LDCT) screening for lung cancer has been proved to reduce lung cancer specific and overall mortality, but the cost-effectiveness of diverse screening strategies remained unclear.

Methods: The comparative cost-effectiveness analysis used a Markov state-transition model to assess the potential effect and costs of the screening strategies incorporating PRS or not.

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Background: Type 2 diabetes (T2D) has been linked with site-specific upper gastrointestinal (UGI) cancers during the past decades, but associations are still inconclusive. This study aimed to determine the association between T2D, glycaemic traits (random blood glucose and HbA1c) and UGI cancer (oesophageal and gastric cancer).

Methods: In the present study, based on the large-scale prospective cohort of UK Biobank, we included 452 631 eligible participants.

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Introduction: Breast cancer is a significant contributor to female mortality, exerting a public health burden worldwide, especially in China, where risk-prediction models with good discriminating accuracy for breast cancer are still scarce.

Methods: A multicenter screening cohort study was conducted as part of the Cancer Screening Program in Urban China. Dwellers aged 40-74 years were recruited between 2014 and 2019 and prospectively followed up until June 30, 2021.

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Article Synopsis
  • This study focused on how patients with advanced colorectal cancer participate in treatment decisions and their perceptions of treatment effectiveness.
  • Data was collected from 4,533 patients across 19 hospitals using a questionnaire that noted demographics and treatment experiences between March 2020 and March 2021.
  • Findings showed that patients' involvement in decision-making varied widely, influenced by demographic factors, and that self-reported treatment efficacy decreased with subsequent treatments.
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Background: Emerging evidence suggests a potential link between psychological distress (anxiety and depression) and lung cancer risk, however, it is unclear whether other factors such as tobacco smoking and genetic susceptibility modify the association.

Methods: We included 405,892 UK Biobank participants free of cancer at baseline. Psychological distress was measured using the Patient Health Questionnaire-4 (PHQ-4).

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Article Synopsis
  • - The study involved 1,688 Chinese patients with metastatic colorectal cancer (mCRC) across 19 hospitals to investigate the use of targeted therapies and the barriers they face in accessing these treatments.
  • - About 51.6% of patients began targeted therapy, with varying rates of first-, second-, and third-line treatments; common barriers included high costs and doubts about treatment effectiveness.
  • - Factors making patients less likely to start targeted therapy included older age, lower education and income levels, lack of medical insurance, and having more severe health issues; addressing cost and enhancing public education could improve treatment access.
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  • * We studied a lot of people from different places to create and test models that can diagnose and predict outcomes for gastric cancer using advanced technology.
  • * Our tests showed that we can effectively find these signs in blood and even predict how well patients will do after diagnosis.
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Disability weights are crucial for quantifying health loss associated with non-fatal outcomes and were not well assessed in different countries, especially for specific cancer. Therefore, this study aimed to identify disability weights with a focus on specific cancer in a large Chinese population. Two types of web surveys were conducted, and 254 health states, including 30 new states for specific cancer, were investigated using paired comparison methods.

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Article Synopsis
  • Low-dose computed tomography (LDCT) screening effectively reduces lung cancer mortality in smokers, but its impact on nonsmokers is less understood.
  • A study conducted in Zhejiang Province, China, evaluated LDCT screening among smokers and nonsmokers who were considered high-risk for lung cancer based on an established risk score model.
  • Results showed higher screening rates and a greater detection of early-stage lung cancer among nonsmokers compared to smokers, with LDCT screening significantly increasing lung cancer incidence in smokers while decreasing lung cancer mortality.
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Obesity is a leading contributor to colorectal cancer (CRC) risk, but the metabolic mechanisms linking obesity to CRC are not fully understood. We leveraged untargeted metabolomics data from two 1:1 matched, nested case-control studies for CRC, including 223 pairs from the US Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial and 190 pairs from a prospective Chinese cohort. We explored serum metabolites related to body mass index (BMI), constructed a metabolomic signature of obesity, and examined the association between the signature and CRC risk.

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  • Tongue images and coating microbiome characteristics, which reflect overall body health in traditional Chinese medicine, were analyzed to diagnose gastric cancer (GC) in a substantial study involving over 1,200 participants.
  • Researchers utilized AI deep learning models to assess the diagnostic potential of these tongue features, with promising results showing high accuracy rates via area under the curve (AUC) metrics: 0.89 for tongue images and 0.94 to 0.95 for microbiome data.
  • The findings suggest that tongue images and microbial analysis can be effective diagnostic tools for GC, marking a significant advancement in non-invasive cancer diagnosis methods.
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  • Calcium is essential for many bodily functions, but its link to mortality in healthy individuals is unclear.
  • A study using data from large health surveys found that both low and high serum calcium levels are associated with increased all-cause and cardiovascular disease mortality, while higher calcium levels correlate positively with cancer mortality.
  • These results suggest a complex relationship between calcium levels and mortality, highlighting the need for further research in the general population.
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To investigate whether genetic variants may provide additional prognostic value to improve the existing clinical staging system for gastric cancer (GC), we performed two genome-wide association studies (GWASs) of GC survival in the Jiangsu ( = 1049) and Shanghai ( = 1405) cohorts. By using a TCGA dataset, we validated genetic markers identified from a meta-analysis of these two Chinese cohorts to determine GC survival-associated loci. Then, we constructed a weighted polygenic hazard score (PHS) and developed a nomogram in combination with clinical variables.

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