Publications by authors named "LingYan He"

The adhesion of marine organisms to marine facilities negatively impacts human productivity. This phenomenon, known as marine fouling, constitutes a serious issue in the marine equipment industry. It increases resistance for ships and their structures, which, in turn, raises fuel consumption and reduces ship speed.

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Rationale: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonotic disease characterized by a high fatality rate of 12% to 15%. Despite hematologic abnormalities being frequently reported in SFTS patients, detailed characterization of peripheral blood cells, especially in severe cases, is scarce. This case report aims to fill this gap by describing the unique morphological features of blood cells in a patient with a severe outcome.

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Patients diagnosed with brain glioma have a poor prognosis and limited therapeutic options. LGR4 is overexpressed in brain glioma and involved in the tumorigenesis of many tumors. Baicalein (BAI) is a kind of flavonoid that has exhibited anti-tumor effects in various tumors.

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Article Synopsis
  • * Analysis of SHD identified 461 active constituents and revealed that it influences various cancer-related pathways and hub genes, potentially affecting glioma characteristics like migration and apoptosis.
  • * SHD was found to enhance the effectiveness of temozolomide (TMZ) in restricting tumor growth, indicating its potential as a complementary therapy for glioblastoma.
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Objectives: This study aimed to evaluate the early effectiveness and safety of belimumab in addition to standard therapy in patients with systemic lupus erythematosus (SLE) for 24 weeks.

Patients And Methods: This retrospective study was conducted with 60 adult patients with active SLE between June 2020 and August 2022. The patients either received intravenous belimumab in addition to standard therapy (n=31; 24 females, 7 males; mean age: 33.

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Article Synopsis
  • - The study focuses on developing a real-time method to identify and analyze sources of particulate matter (PM) pollution, which is important for reducing pollution levels effectively.
  • - The method, based on chemical mass balance modeling and online monitoring, found that secondary sulfate, secondary organic aerosol, vehicle emissions, and secondary nitrate accounted for 76% of PM sources in Shenzhen during autumn 2019.
  • - The new method was validated against traditional techniques and revealed that vehicle emissions significantly contribute to both primary and secondary organic aerosols, highlighting its potential for improving aerosol pollution control and understanding emissions better.
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Surface ozone pollution, as a pressing environmental concern, has garnered widespread attention across China. Due to air mass transport, effective control of ozone pollution is highly dependent on collaborative efforts across neighboring regions. However, specific regions with strong internal interactions of ozone pollution are not yet well identified.

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Formaldehyde (HCHO) is one of the key indicators of severe photochemical pollution and strong atmospheric oxidation capacity in southern China. However, current information on the origins of regional HCHO and the impacts of polluted air masses remains scarce and unclear. In this study, an intensive observation of HCHO was conducted at a mountainous background site in southern China during typical photochemical pollution episodes.

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Large missing sources of daytime atmospheric nitrous acid (HONO), a vital source of hydroxyl radicals (OH) through its photolysis, frequently exist in global coastal regions. In this study, ambient HONO and relevant species were measured at a coastal site in the Pearl River Delta (PRD), China, during October 2019. Relatively high concentrations (0.

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As non-point source pollution has emerged as a significant global and regional concern, climate change (CC), land use/cover transformation (LUCT), and management practices (MP) play vital roles in addressing nutrient pollution. However, current studies lack comprehensive quantification and consistent conclusions on the response to these factors, especially for management practices. To quantify and elucidate the impact of representative environmental factors on rapidly urbanizing regions, this study focused on the Shenzhen River, which serves as the most typical urbanizing watershed.

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As precursors of photochemical secondary pollutants, oxygenated volatile organic compounds (OVOCs) play an important role in atmospheric photochemistry. In this study, 23 OVOCs were monitored using a commercial proton transfer reaction time-of-flight mass spectrometer at an urban site in Shenzhen, China. During the campaign, the mean total concentration of OVOCs was 23.

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Apprehending the hydrological and nutrient variations in rapidly urbanizing watersheds under changing environments is crucial for pollution control and water resource management. However, existing studies have primarily focused on hydrological processes, neglecting water quality aspects, and comprehensive assessment of future runoff and nutrient loads in these watersheds during China's Dual Carbon periods is limited. This study firstly bridges these gaps by constructing multi-scenario with different levels of "Urban Development - Ecological Conservation" and utilizing latest bias-corrected General Circulation Models or Global Climate Models (GCMs) projections to evaluate future runoff and nutrient loads in the Shenzhen River.

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The Pearl River (PR) is China's second-largest river, playing a crucial role in regulating and supplying water in the southeast. However, for the last decade, the PR has been experiencing water quality deterioration due to population growth, rapid economic development, and diverse human activities, particularly in its delta areas. This study analyzed the characteristics and evolution of eight water quality variables, including pH values (pH), water temperature (WT), dissolved oxygen (DO), five-day biochemical oxygen demand (BOD), permanganate index (PI), total phosphorus (TP), ammonia nitrogen (NHN), and fluoride (F), which were monitored monthly at 16 water quality monitoring stations from January 2009 to August 2019.

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Purpose: Glioma is the most common and fatal type of brain tumour. Owing to its aggressiveness and lethality, early diagnosis and prediction of patient survival are very important. This study aimed to identify key genes and biomarkers for glioma that can guide clinicians in making rapid diagnosis and prognostication.

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Patients diagnosed with stable coronary artery disease (CAD) are at continued risk of experiencing acute myocardial infarction (AMI). This study aims to unravel the pivotal biomarkers and dynamic immune cell changes, from an immunological, predictive, and personalized viewpoint, by implementing a machine-learning approach and a composite bioinformatics strategy. Peripheral blood mRNA data from different datasets were analyzed, and CIBERSORT was used for deconvoluting human immune cell subtype expression matrices.

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Post-stroke depression (PSD) negatively affects the prognosis of post-stroke animals. Ramelteon has neuroprotection for chronic ischemia animals, but the effect and the biological mechanism of it on PSD is still unclear. This study explored the effects of ramelteon with prophylactic administration on blood-brain barrier in rats with middle cerebral artery occlusion (MCAO) and the oxygen-glucose deprivation/reperfusion (OGD/R) bEnd.

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The main objective of this paper is to study the impact of the Ambient Air Quality Standard (2012) on the green innovation of Chinese firms in polluting industries. The analysis features "leverage effect" of Porter Hypothesis imposed by environmental regulations and exploits exogenous variations caused by the promulgation of the new policy. Based on the exogenous variations, this paper uses the time varying PSM-DID method.

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Article Synopsis
  • - This study investigates how black carbon (BC) interacts with other materials and its impact on climate, especially in the Pearl River Delta, China, where knowledge is limited.
  • - Researchers used advanced mass spectrometers to analyze submicron BC and its associated materials during different atmospheric conditions: polluted periods (PP) and clean periods (CP).
  • - They discovered that more-oxidized organic factors (MO-OOA) form more readily on BC during polluted periods due to increased photochemical and nighttime reactions, suggesting that these interactions should be included in climate models for better accuracy.
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Atmospheric oxidizing capacity (AOC) is an essential driving force of troposphere chemistry and self-cleaning, but the definition of AOC and its quantitative representation remain uncertain. Driven by national demand for air pollution control in recent years, Chinese scholars have carried out studies on theories of atmospheric chemistry and have made considerable progress in AOC research. This paper will give a brief review of these developments.

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Article Synopsis
  • Tropospheric ozone (O) is harmful to humans and plants and contributes to climate change, forming from reactions between nitrogen oxides and volatile organic compounds in the presence of light.
  • A study investigated a pollution episode in Shenzhen, China in 2018, using a box model to evaluate how aerosols affected local O production.
  • Findings indicated that aerosols had opposing effects on O production, and reducing nitrogen oxides (NO) could help mitigate both O and fine particulate pollution.
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Refractory black carbon (rBC) aerosols emitted from incomplete combustion are important climate forcers. Understanding the chemical characteristics and evolution of rBC-related components is particularly crucial to assess rBC environmental impacts. Here, we explored the chemical components of rBC in Shenzhen, China, using a soot-particle aerosol mass spectrometer (SP-AMS).

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  • Ambient ozone air pollution is a major environmental issue in China, highlighting the need to identify pollution sources and develop control strategies.
  • A new method called PMF-SHAP combines positive matrix factorization and SHAP to evaluate the impact of emission sources on ozone formation, achieving a high prediction accuracy of 0.96.
  • The study found that volatile organic compounds (VOCs), particularly from vehicle emissions, significantly contribute to ozone formation in Shenzhen, suggesting a better approach to tackle environmental pollution by integrating traditional and machine learning models.
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Manipulating the frequency and bandwidth of nonclassical light is essential for implementing frequency-encoded/multiplexed quantum computation, communication, and networking protocols, and for bridging spectral mismatch among various quantum systems. However, quantum spectral control requires a strong nonlinearity mediated by light, microwave, or acoustics, which is challenging to realize with high efficiency, low noise, and on an integrated chip. Here, we demonstrate both frequency shifting and bandwidth compression of heralded single-photon pulses using an integrated thin-film lithium niobate (TFLN) phase modulator.

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Integrated femtosecond pulse and frequency comb sources are critical components for a wide range of applications, including optical atomic clocks, microwave photonics, spectroscopy, optical wave synthesis, frequency conversion, communications, lidar, optical computing and astronomy. The leading approaches for on-chip pulse generation rely on mode-locking inside microresonators with either third-order nonlinearity or with semiconductor gain. These approaches, however, are limited in noise performance, wavelength and repetition rate tunability .

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Herein, we use an oxidation flow reactor, Gothenburg: Potential Aerosol Mass (Go: PAM) reactor, to investigate the secondary organic aerosol (SOA) formation from wheat straw burning. Biomass burning emissions are exposed to high concentrations of hydroxyl radicals (OH) to simulate processes equivalent to atmospheric oxidation of 0-2.55 days.

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