Mechanism of Dendrobium Nobile Polysaccharide Inhibition of Ferroptosis in Rats with Spinal Cord Injury.

Background: It has been reported that ferroptosis participates in the pathophysiological mechanism of spinal cord injury (SCI). Our preliminary experiments verified that dendrobium nobile polysaccharide (DNP) improved the behavioral function of SCI rats. Therefore, the purpose of this study was to examine the role of DNP on ferroptosis and its neuroprotective mechanism in SCI rats.

Specific rules for time and space of multisensory plasticity in the superior colliculus.

Cat superior colliculus (SC) neurons commonly combine information from different senses, which facilitates event detection and localization. Integration in SC multisensory neurons depends on the spatial and temporal relationships between cross-modal cues. Here, we revealed the parallel process of short-term plasticity in the temporal/spatial integration process during adulthood that adapts multisensory integration to reliable changes in environmental conditions.

Factors associated with health-related quality of life among family caregivers of people with Alzheimer's disease.

Aim: Based on the ageing population and the inadequate healthcare system in China, the majority of care for patients with Alzheimer's disease (AD) is provided by family caregivers. Caregivers suffer a long-term heavy care burden and pressure, which affects their physical and mental health. The present study aims at investigating health-related quality of life (HRQOL) among family caregivers of AD patients and exploring its influencing factors.

Evaluation of Safety and Efficacy of Growth Hormone Therapy by IGF-1 Z Score in Children with Short Stature.

Introduction: This study aims to explore the safety and efficacy of growth hormone (GH) therapy by retrospectively analyzing the changes of insulin-like growth factor-1 (IGF-1) Z-scores in children with short stature after treatment with GH.

Methods: The etiology of 104 children with short stature was classified according to the GH stimulation test and IGF-1 levels: (1) growth hormone deficiency (GHD); (2) mild growth hormone deficiency (M-GHD); (3) idiopathic short stature (ISS); (4) GH insensitivity syndrome (GHIS). In addition, all patients were treated with recombinant human growth hormone (rhGH) for 12 months, and the growth rate (Gv), height, body mass, bone age, height standard deviation scores (HtSDS), IGF-1 and adverse reactions were compared among these three groups before and after treatment.

Sexual Activity and HIV-Related Knowledge among Secondary School Students in China.

Objective: The aim of this study was to assess the level of HIV/AIDS knowledge and sexual activity among secondary school students, and to offer specific intervention strategies.

Materials And Methods: Random sampling technique was used and cross-sectional study was conducted among 6347 students using self-administered questionnaire.

Results: The ages of participants range from 9 to 21 years with a mean of 14.

Evaluation of the Influence of Etiological Factors on the Economic Burden of Ischemic Stroke in Younger Patients in China Using the Trial of Org 10172 in Acute Stroke Treatment (TOAST) Classification.

BACKGROUND Worldwide, stroke results in healthcare costs and economic costs, particularly in patients aged <45 years. This study aimed to evaluate the factors influencing the economic burden of ischemic stroke in younger patients in China based on the Trial of Org 10172 in Acute Stroke Treatment (TOAST) etiological classification. MATERIAL AND METHODS Retrospective review of the medical records of 961 patients aged between 18-45 years, diagnosed with acute ischemic stroke, was performed to identify healthcare costs for one year.

[Expression of the MYL2 gene in the development of rat testis tissue].

Objective: To study the expression of the gene of myosin regulatory light chain-2 (MYL2) in the development of rat testis tissue.

Methods: Using real-time PCR and immunohistochemistry, we determined the mRNA transcription level and protein expression of MYL2 in the rat testis.

Results: The mRNA expression of the MYL2 gene changed in an age-dependent manner, reaching the highest value on postnatal day (PND) 2, then dropped rapidly till PND 8, increased slowly on PNDs 10 and 12, decreased on PND 14, rose slightly from PND 15 and rapidly on PNDs 20 and 25, and declined slowly from PND 65.

Rasd1 is an estrogen-responsive immediate early gene and modulates expression of late genes in rat anterior pituitary cells.

Dexamethasone-induced Ras-related protein 1 (Rasd1) is a member of the Ras superfamily of monomeric G proteins that have a regulatory function in signal transduction. Here we investigated the role of Rasd1 in regulating estrogen-induced gene expression in primary cultures of rat anterior pituitary cells. Rasd1 mRNA expression in anterior pituitary cells decreased after treatment with forskolin or serum and increased after treatment with 17β-estradiol (E2).

Anticancer potential of bioactive peptides from animal sources (Review).

Cancer is the most common cause of human death worldwide. Conventional anticancer therapies, including chemotherapy and radiation, are associated with severe side effects and toxicities as well as low specificity. Peptides are rapidly being developed as potential anticancer agents that specifically target cancer cells and are less toxic to normal tissues, thus making them a better alternative for the prevention and management of cancer.

Correlation analysis of anxiety status and sub-health status among students of 13-26 years old.

The purpose of the survey is to investigate the relationship between anxiety statuses and suboptimal health status among students from south of Anhui in china. Our study was a population-based, cluster sampling method survey with a sample consisting of 5249 students, who come from a university, four high schools and four middle schools in Wannan Area in China. Sub-health status was measured by multidimensional sub-health questionnaire of adolescents, and anxious status was assessed using anxiety self-assessment scale.

Association between serum uric acid levels and obesity among university students (China).

Objective: To evaluate the association between serum uric acid and obesity among university students who participated in routine health screening in 2013.

Methods: In this cross-sectional study, 3529 subjects were analyzed. Obesity categories were classified by BMI levels references in China.

Blood lipid profile and glucose of university students (China).

Objective: The main objective of this study was to estimate the blood glucose and blood lipid profile of students in a university in China.

Methods: This descriptive study was based on the health screening data for university students in 2013. The blood glucose (GLU), lipid profiles (total cholesterol (TC), triglyceride (TG, and high density lipoprotein (HDL-C)) was measured by using Hitachi model 747 automatic analyzer.

Prevalence of overweight and obesity among secondary school children aged 14 to 18 years (china).

Background: Prevalence of overweight and obesity in adolescents has been increasing during recent decades. The present study aimed to assess the prevalence of obesity in 14-18 years old Anhui Secondary school children, and provide more comprehensive guidelines for intervention programs.

Methods: This cross-sectional study was conducted among 4788 children in secondary school, and date from the routine health survey was analyzed.

[SNP microarray analysis of retention abortion chorionic villus].

Objective: To compare villus cell culture and karyotype analysis with single nucleotide polymorphism (SNP) microarray technology for the detection of chorionic villus chromosome in patients with retention of abortion.

Methods: Forty cases were analyzed with the two methods.

Results: Chorionic villus culturing was successful in 29 cases, among which 10 were found to have an abnormal karyotypes.

Thiazide-sensitive Na+-Cl- cotransporter: genetic polymorphisms and human diseases.

The thiazide-sensitive Na(+)-Cl(-) cotransporter (TSC) is responsible for the major sodium chloride reabsorption pathway, which is located in the apical membrane of the epithelial cells of the distal convoluted tubule. TSC is involved in several physiological activities including transepithelial ion absorption and secretion, cell volume regulation, and setting intracellular Cl(-) concentration below or above its electrochemical potential equilibrium. In addition, TSC serves as the target of thiazide-type diuretics that are the first line of therapy for the treatment of hypertension in the clinic, and its mutants are also reported to be associated with the hereditary disease, Gitelman's syndrome.

Prevalence and risk factors of anxiety status among students aged 13-26 years.

Previous study revealed that 8%-12% adolescents suffered from various types of anxiety disorders, and which had interfered with adolescent daily life function and affected adolescent social function. The aim of this study was to evaluate anxiety status and its related factors among students aged 13-26 years from Wuhu, China. This was a cross-sectional observational study.

The role of social support on occupational stress among hospital nurses.

Stress is a nonspecific reaction to everything the body needs. Although occupational stress exists in every occupation, it is seen with more frequency and intensity amongst those occupations related to human health. In this study, we aimed to investigate the relationship between occupational stress and social support (SS) among hospital nurses.

Prevalence of overweight and obesity among primary school children aged 5 to 14 years in Wannan area, China.

Background: Overweight and obesity are epidemic worldwide. The purpose of this research is to estimate whether the prevalence of obesity among primary school children is high, and to identify its potential determinants to optimize the methods of prevention to combat further increases in childhood overweight.

Methods: A cross-sectional study was designed to collect the routine health screening data for primary school children in Wannan area, China.

Hypertension prevalence, awareness, treatment, and control and sodium intake in Shandong Province, China: baseline results from Shandong-Ministry of Health Action on Salt Reduction and Hypertension (SMASH), 2011.

Introduction: In China, population-based blood pressure levels and prevalence of hypertension are increasing. Meanwhile, sodium intake, a major risk factor for hypertension, is high. In 2011, to develop intervention priorities for a salt reduction and hypertension control project in Shandong Province (population 96 million), a cross-sectional survey was conducted to collect information on sodium intake and hypertension prevalence, awareness, treatment, and control.

Prevalence of underweight, overweight and obesity in university students from the region of Anhui (China).

Background: Overweight and obesity are epidemic worldwide. Our previous study found that the prevalence of overweight and obesity in primary students is high.

Objective: we sought to estimate whether the prevalence of overweight and obesity among university students is still high in China.

Effect of abiotic stress on the abundance of different vitamin B6 vitamers in tobacco plants.

There are six different vitamin B6 (VB6) forms, pyridoxal (PL), pyridoxamine (PM), pyridoxine (PN), pyridoxal 5'-phosphate (PLP), pyridoxamine 5'-phosphate (PMP), and pyridoxine 5'-phosphate (PNP), of which PLP is the active form. Although transcriptional regulation of the genes involved in the de novo and salvage pathways of PLP syntheses after stress treatments has been described for Arabidopsis thaliana and tobacco plants, it remains open as to whether this in turn affects VB6 levels. In this study, the effects of chilling, UV radiation, intensity of illumination, osmotic pressure, oxidative and drought stresses on the abundance of different B6 vitamers in tobacco plants were examined by using high performance liquid chromatography (HPLC).