Publications by authors named "Ling-hong Chen"
Aim: Glutamatergic neurotransmission in the nucleus accumbens (NAc) is crucial for the relapse to heroin seeking. The aim of this study was to determine whether mGluR5 in the NAc core or shell involved in heroin seeking behavior in rats.
Methods: Male SD rats were self-administered heroin under a fixed-ratio 1 (FR1) reinforcement schedule for 14 d, and subsequently withdrawn for 2 weeks.
Objectives: Long-term use of methamphetamine (MA) induces the neuron damage and leads to multiple neuropsychiatric disorders. However, the effect of MA on the female reproductive functions has not yet been evaluated. The objective of this study was to determine the prevalence of abnormal menstrual cycling in female MA users.
View Article and Find Full Text PDFWe recently found that moderate consumption of two unrelated red wines generate from different grape species, a Cabernet Sauvignon and a muscadine wine that are characterized by distinct component composition of polyphenolic compounds, significantly attenuated the development of Alzheimer's disease (AD)-type brain pathology and memory deterioration in a transgenic AD mouse model. Interestingly, our evidence suggests that the two red wines attenuated AD phenotypes through independent mechanisms. In particular, we previously found that treatment with Cabernet Sauvignon reduced the generation of AD-type amyloid-beta (Abeta) peptides.
View Article and Find Full Text PDFAims: The fragile histidine triad (FHIT) gene is frequently inactivated in human cancers; however, the FHIT gene remains unexplored in Hodgkin's lymphoma. The aim of this study was to investigate the role of FHIT expression in classical Hodgkin's lymphoma.
Methods: Classical Hodgkin's lymphomas were analysed for FHIT gene expression by two-step non-biotin immunohistochemical method and Western blotting.
Objective: To study the expression of FHIT protein and its potential application in diagnosing classic Hodgkin lymphoma.
Methods: Immunohistochemical study using EnVision method for FHIT tumor suppressor protein, hematopoietic stem cell markers CD133/AC133 and CD34, B-cell marker CD20, T-cell marker CD3 and oncoprotein c-erbB2 was performed on 33 cases of classic Hodgkin lymphoma.
Results: Thirty-three of the Hodgkin lymphoma cases (90.
The ratio of MMP-2 to TIMP-2 in hilar cholangiocarcinoma: a semi-quantitative study.
Hepatobiliary Pancreat Dis Int
November 2004
Article Synopsis
- - The study focuses on hilar cholangiocarcinoma, highlighting its low resectability and poor survival rates while examining the roles of MMP-2 and TIMP-2 in tumor invasion and prognosis.
- - Researchers analyzed tissue samples from 50 patients, using immunohistochemical methods and image analysis software to assess MMP-2 and TIMP-2 expression levels and their ratios.
- - Findings indicate that MMP-2 is linked to increased tumor invasion, whereas TIMP-2 inhibits it; the MMP-2 to TIMP-2 ratio could serve as a prognostic marker for patient outcomes.