Publications by authors named "Ling-Yun Pan"

Purpose: Docetaxel (DTX) is a valuable anti-tumor chemotherapy drug with limited oral bioavailability. This study aims to develop an effective oral delivery system for DTX using natural nanoparticles (Nnps) derived from Coptidis Rhizoma extract.

Methods: DTX-loaded self-assembled nanoparticles (Nnps-DTX) were created using an optimized heat-induction strategy.

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This study established a method for simultaneous determination of 11 neurotransmitters, such as acetylcholine, glutamic acid, glycine, and norepinephrine from rat brain microdialysis samples using UPLC-MS/MS. A total of 20 μL of rat brain dialysate was diluted with 60 μL of acetonitrile-water(4∶1) and centrifuged for 10 min at 10 000 r·min~(-1),and 5 μL was injected into UPLC-MS/MS system for assay. Chromatographic separation was performed on a Waters ACQUITY BEH amide column(2.

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The objective of this study was to apply a machine learning method to evaluate the risk factors associated with serious adverse events (SAEs) and predict the occurrence of SAEs in cancer inpatients using antineoplastic drugs. A retrospective review of the medical records of 499 patients diagnosed with cancer admitted between January 1 and December 31, 2017, was performed. First, the Global Trigger Tool (GTT) was used to actively monitor adverse drug events (ADEs) and SAEs caused by antineoplastic drugs and take the number of positive triggers as an intermediate variable.

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In this paper, we explore whether interparticle spacing affects steady-state and transient-state optical properties by comparing close-packed CdSe/ZnS-quantum dots (QDs) and CdSe/ZnS-QDs dispersed in polymethyl methacrylate (PMMA). High-pressure is an effective physical means to adjust the interparticle spacing of QDs, which may artificially expand the application of QDs further. The results under high-pressure indicate that it is the reduced interparticle spacing rather than the enhanced quantum confinement effect with volume compression that has a stronger effect on exciton relaxation of CdSe/ZnS-QDs.

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We detected disproportionate reports of premature ovarian insufficiency (POI) and related events, including amenorrhea, menstruation irregular, FSH increased, and premature menopause, following human papillomavirus (HPV) vaccine from FDA Vaccine Adverse Event Reporting System (VAERS). The signal was detected by the methods of Bayesian Confidence Propagation Neural Network (BCPNN) and Multi-item Gamma Poisson Shrinker (MGPS). When both methods detected a positive result, a signal was generated.

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Gamboge, a dried resin secreted by Garcinia hanburyi Hook. f. (Guttiferae), possesses remarkable anticancer activity.

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Objective: To observe the expression of Ginkgo biloba Tablet (GbT) on scavenger receptor A (SRA) of the aortic wall and changes of serum inflammatory factors in atherosclerotic rats, and to explore its new mechanism for fighting against atherosclerosis (AS).

Methods: Totally 45 male Wistar rats were randomly divided into the control group, the model group, the GbT group, 15 rats in each group. Levels of blood glucose, blood lipids, blood calcium, serum C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (slCAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured in all rats.

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Article Synopsis
  • The study examines the toxicity of crude gamboges (a natural resin) after oral administration and how its harmful effects can be reduced through processing.
  • It used various assays to measure inflammatory substances in rat tissues, finding that crude gamboges increased inflammation and caused serious gastrointestinal issues, while processed gamboges showed reduced inflammatory responses.
  • Additionally, the research indicated that changes in the expression of aquaporin proteins (AQP3 and AQP4) in the gastric and duodenal tissues played a role in how processing gambo lessened its toxicity.
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Advanced technologies are used to clarify the meridian tropism theory of traditional Chinese medicine is an important part of theoretical studies of traditional Chinese medicine. In this article, modern pharmacokinetic method was used to investigate tissue distribution characteristics of psoralen and isopsoralen of Psoraleae Fructus decoction in rats, in order to provide research ideas and experimental basis for the meridian tropism theory. In this study, various tissue samples such as heart, liver, spleen, lung, kidney, brain and spermary were collected at different times after oral administration with FP decoction, in order to determine concentration of psoralen and isopsoralen by HPLC.

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As the priority of interconnects and active components in nanoscale optical and electronic devices, three-dimensional hyper-branched nanostructures came into focus of research. Recently, a novel crystallization route, named as "nonclassical crystallization," has been reported for three-dimensional nanostructuring. In this process, Quantum dots are used as building blocks for the construction of the whole hyper-branched structures instead of ions or single-molecules in conventional crystallization.

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In this work, we report a luminescent nanobundle structure formed by a hierarchical self-assembly process of thioglycolic acid (TGA)-capped CdTe quantum dots (QDs). The luminescence intensity of CdTe nanostructures is high enough to get a clear one-photon excitation confocal image. High contrast two-photon excitation confocal images suggest that the nonlinear properties of pristine QDs are well inherited by the formed CdTe nanostructures.

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In this paper, we report a novel nanobundle structure formed by the hierarchical self-assembly of TGA-capped CdTe quantum dots. HR-TEM confirms the polycrystalline phase of the bundle structure, and that pristine quantum dots are the building units. The steady state absorption and luminescence properties of the pristine quantum dots can be well inherited by the nanobundles.

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Article Synopsis
  • Researchers investigated a specific type of molecule called CNDPASDB using time-resolved fluorescence techniques to understand its behavior in different solvents and states.
  • The study found that CNDPASDB shows a significant change in its emission properties depending on the polarity of the solvent, with a rapid transition to a charge transfer state in polar solvents.
  • In aggregate form, the molecule restricts its internal movement, leading to less polarity and enabling efficient aggregation-induced emission (AIE).
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Objective: To study the effect of cortisol and dehydroepiandrosterone sulfate (DHEA-S) in fetal umbilical cord blood on term labor.

Methods: Cortisol and DHEA-S concentrations were measured By radioimmunoassay in 100 term fetal umbilical cord blood. They were divided into four groups.

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