Int J Nanomedicine
August 2024
Purpose: Docetaxel (DTX) is a valuable anti-tumor chemotherapy drug with limited oral bioavailability. This study aims to develop an effective oral delivery system for DTX using natural nanoparticles (Nnps) derived from Coptidis Rhizoma extract.
Methods: DTX-loaded self-assembled nanoparticles (Nnps-DTX) were created using an optimized heat-induction strategy.
Zhongguo Zhong Yao Za Zhi
June 2022
This study established a method for simultaneous determination of 11 neurotransmitters, such as acetylcholine, glutamic acid, glycine, and norepinephrine from rat brain microdialysis samples using UPLC-MS/MS. A total of 20 μL of rat brain dialysate was diluted with 60 μL of acetonitrile-water(4∶1) and centrifuged for 10 min at 10 000 r·min~(-1),and 5 μL was injected into UPLC-MS/MS system for assay. Chromatographic separation was performed on a Waters ACQUITY BEH amide column(2.
View Article and Find Full Text PDFThe objective of this study was to apply a machine learning method to evaluate the risk factors associated with serious adverse events (SAEs) and predict the occurrence of SAEs in cancer inpatients using antineoplastic drugs. A retrospective review of the medical records of 499 patients diagnosed with cancer admitted between January 1 and December 31, 2017, was performed. First, the Global Trigger Tool (GTT) was used to actively monitor adverse drug events (ADEs) and SAEs caused by antineoplastic drugs and take the number of positive triggers as an intermediate variable.
View Article and Find Full Text PDFNanomaterials (Basel)
January 2021
In this paper, we explore whether interparticle spacing affects steady-state and transient-state optical properties by comparing close-packed CdSe/ZnS-quantum dots (QDs) and CdSe/ZnS-QDs dispersed in polymethyl methacrylate (PMMA). High-pressure is an effective physical means to adjust the interparticle spacing of QDs, which may artificially expand the application of QDs further. The results under high-pressure indicate that it is the reduced interparticle spacing rather than the enhanced quantum confinement effect with volume compression that has a stronger effect on exciton relaxation of CdSe/ZnS-QDs.
View Article and Find Full Text PDFWe detected disproportionate reports of premature ovarian insufficiency (POI) and related events, including amenorrhea, menstruation irregular, FSH increased, and premature menopause, following human papillomavirus (HPV) vaccine from FDA Vaccine Adverse Event Reporting System (VAERS). The signal was detected by the methods of Bayesian Confidence Propagation Neural Network (BCPNN) and Multi-item Gamma Poisson Shrinker (MGPS). When both methods detected a positive result, a signal was generated.
View Article and Find Full Text PDFJ Chromatogr B Analyt Technol Biomed Life Sci
September 2019
Gamboge, a dried resin secreted by Garcinia hanburyi Hook. f. (Guttiferae), possesses remarkable anticancer activity.
View Article and Find Full Text PDFZhongguo Zhong Xi Yi Jie He Za Zhi
April 2016
Objective: To observe the expression of Ginkgo biloba Tablet (GbT) on scavenger receptor A (SRA) of the aortic wall and changes of serum inflammatory factors in atherosclerotic rats, and to explore its new mechanism for fighting against atherosclerosis (AS).
Methods: Totally 45 male Wistar rats were randomly divided into the control group, the model group, the GbT group, 15 rats in each group. Levels of blood glucose, blood lipids, blood calcium, serum C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (slCAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured in all rats.
Zhongguo Zhong Yao Za Zhi
April 2013
Advanced technologies are used to clarify the meridian tropism theory of traditional Chinese medicine is an important part of theoretical studies of traditional Chinese medicine. In this article, modern pharmacokinetic method was used to investigate tissue distribution characteristics of psoralen and isopsoralen of Psoraleae Fructus decoction in rats, in order to provide research ideas and experimental basis for the meridian tropism theory. In this study, various tissue samples such as heart, liver, spleen, lung, kidney, brain and spermary were collected at different times after oral administration with FP decoction, in order to determine concentration of psoralen and isopsoralen by HPLC.
View Article and Find Full Text PDFAs the priority of interconnects and active components in nanoscale optical and electronic devices, three-dimensional hyper-branched nanostructures came into focus of research. Recently, a novel crystallization route, named as "nonclassical crystallization," has been reported for three-dimensional nanostructuring. In this process, Quantum dots are used as building blocks for the construction of the whole hyper-branched structures instead of ions or single-molecules in conventional crystallization.
View Article and Find Full Text PDFIn this work, we report a luminescent nanobundle structure formed by a hierarchical self-assembly process of thioglycolic acid (TGA)-capped CdTe quantum dots (QDs). The luminescence intensity of CdTe nanostructures is high enough to get a clear one-photon excitation confocal image. High contrast two-photon excitation confocal images suggest that the nonlinear properties of pristine QDs are well inherited by the formed CdTe nanostructures.
View Article and Find Full Text PDFIn this paper, we report a novel nanobundle structure formed by the hierarchical self-assembly of TGA-capped CdTe quantum dots. HR-TEM confirms the polycrystalline phase of the bundle structure, and that pristine quantum dots are the building units. The steady state absorption and luminescence properties of the pristine quantum dots can be well inherited by the nanobundles.
View Article and Find Full Text PDFZhonghua Fu Chan Ke Za Zhi
January 2003
Objective: To study the effect of cortisol and dehydroepiandrosterone sulfate (DHEA-S) in fetal umbilical cord blood on term labor.
Methods: Cortisol and DHEA-S concentrations were measured By radioimmunoassay in 100 term fetal umbilical cord blood. They were divided into four groups.