Publications by authors named "Ling-Yin Kong"

Background: Cryptic translocations can be identified via genetic analysis of aborted tissues or malformed infants, but it is difficult to deduce the parental origins of the translocations. In the absence of such information, it is not easy to distinguish translocations from normal embryos during pre-implantation genetic testing, that seeks to block familial transmission of translocations.

Methods: Here, we present a new method that detects cryptic translocations and blocks familial transmission thereof.

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Article Synopsis
  • This study investigates whether noninvasive embryo viability testing (niEVT) leads to improved clinical outcomes compared to conventional IVF after the first embryo transfer, focusing on live birth rates, particularly for different age groups including women over 35 years old.
  • A double-blind, multicenter randomized controlled trial will enroll 1,140 patients across eight centers, who have at least two high-quality blastocysts, to assess multiple outcomes including live birth and miscarriage rates.
  • The results will help clarify the effectiveness of niEVT versus traditional IVF methods, potentially influencing treatment options and success rates for various patient demographics.
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Research Question: Non-invasive preimplantation genetic testing for aneuploidies (niPGT-A) avoids the possible detrimental impact of invasive PGT-A on embryo development and clinical outcomes. Does cell-free DNA (cfDNA) from spent blastocyst culture medium (BCM) reflect embryonic chromosome status better than trophectoderm (TE) biopsy?

Design: In this study, 35 donated embryos were used for research and the BCM, TE biopsy, inner cell mass (ICM) and residual blastocyst (RB) were individually picked up from these embryos. Whole genome amplification (WGA) was performed and amplified DNA was subject to next-generation sequencing.

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Marfan syndrome (MFS) is caused by a mutation. Many organ systems are affected in patients with MFS, including the skeletal, ocular, cardiovascular and pulmonary systems. Cardiovascular manifestations are the main cause of mortality in patients with MFS.

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Emerging evidence suggests that the coupling relating the structural connectivity (SC) of the brain to its functional connectivity (FC) exhibits remarkable changes during development, normal aging, and diseases. Although altered structural-functional connectivity couplings (SC-FC couplings) have been previously reported in schizophrenia patients, the alterations in SC-FC couplings of different illness stages of schizophrenia (SZ) remain largely unknown. In this study, we collected structural and resting-state functional MRI data from 73 normal controls (NCs), 61 first-episode (FeSZ) and 78 chronic (CSZ) schizophrenia patients.

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Silver-Russell syndrome (SRS) is a rare, well-recognized disorder characterized by growth restriction, including intrauterine and postnatal growth. Most SRS cases are caused by hypomethylation of the paternal imprinting center 1 (IC1) in chromosome 11p15.5 and maternal uniparental disomy in chromosome 7 (UPD7).

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In the current study, one case of COG5-CDG involving a Chinese male patient with severe neurological symptoms, who had previously been misdiagnosed with congenital gyrus malformation, is described. A clinical investigation was performed and targeted next-generation sequencing (NGS) was used to identify COG5 variants in the patient and his family. PCR and Sanger sequencing were performed for the verification of NGS results.

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The 14-3-3 proteins comprise a family of highly conserved acidic protein with subunit molecular mass 28-33kD and are widely found in different eukaryotic cells. 14-3-3 proteins were the first polypeptides shown to have phosphoserine/threonine (pSer/Thr) binding properties which firmly established its importance in cell signaling. 14-3-3 proteins tend to form dimeric proteins to modulate protein-protein interactions.

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