Publications by authors named "Ling-Xia Chen"
Status epilepticus (SE) is a life-threatening disorder that can result in death or severe brain damage, and there is a substantial body of evidence suggesting a strong association between pyroptosis and SE. Sterol regulatory element binding protein 1 (SREBP1) is a significant transcription factor participating in both lipid homeostasis and glucose metabolism. However, the function of SREBP1 in pyroptosis during SE remains unknown.
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- Hepatitis E virus infection is primarily known for causing liver-related symptoms but can also lead to serious conditions like immune-mediated thrombotic thrombocytopenic purpura (TTP), as illustrated in a unique case study.
- A 53-year-old male patient presented with fever, low platelet count (thrombocytopenia), and liver dysfunction, ultimately diagnosed with acute hepatitis E, which triggered TTP.
- Following specific treatments, including plasmapheresis and glucocorticoids, the patient showed significant improvement, highlighting the importance of screening for hepatitis E in patients with liver issues and low platelet counts.
[Study on Calpain10 gene polymorphism in Chinese type 2 diabetes families].
Zhonghua Yi Xue Za Zhi
November 2003
Objective: To detect the Calpain10 gene polymorphisms in North China families with type 2 diabetes and to investigate their association with type 2 diabetes.
Methods: PCR-RFLP method was used to test the polymorphisms of Calpain10 SNP43 (G/A) and SNP19 (1/2) in 801 individuals from 218 type 2 diabetes mellitus (DM) families, 211 type 2 diabetes patients without family history, and 127 normal control subjects in northern China.
Results: (1) The Calpain 10 SNP43 "G" allele frequency was 91.